[The morphological and cytogenetic aspects in a study of chorionic and placental biopsies in pregnant women who are over the age of 35]. / Morfolohichni ta tsytohenetychni aspekty pry doslidzhenni bioptatu khoriona i platsenty u vahitnykh zhinok, vik iakykh perevyshchuie 35 rokiv.

Perinatal pathology and morbidity takes the leading role in children pathology and morbidity today. These indices are of significance for the pregnant women of high risk group pregnant women in the age of 35 and above occupying peculiar place in this group. In this connection the morphological studies of chorion and placenta biopsies in this group of patients are important and urgent. The cytogenetical analysis of these tissues allows one to solve completely the problems of the presence or absence of chromosome fetal malformations in terms of 8-24 weeks, when the elimination of fetus is still possible.

[The prenatal cytogenetic diagnosis of fetal chromosomal pathology in women in a high-risk group]. / Prenatal'na tsytohenetychna diahnostyka khromosomnoï patolohiï plodu u zhinok hrupy vysokoho ryzyku.

The results of investigation of 908 chorion and placental biopsy in 873 pregnant women of high risk a group is presented. Fetal pathology was diagnosed with the help of "direct" method and shot-term method of culture of chorionic villi and placenta, as well as method of long-term fetal lymphocyte cultures. The efficiency of invasive methods of prenatal diagnosis, and their role in decrease of perinatal disease and mortality was confirmed.

[Cytogenetic study of the chorion and placenta in prenatal diagnosis of fetal pathology]. / Tsytohenetychne doslidzhennia khorionu ta platsenty v prenatal'nii diahnostytsi patolohiï plodu.

The experience of investigation of 230 chorion and placental biopsy in 209 women of high risk pregnancy group is presented. Two methods of "direct" chromosomal analysis have been compared. Prospects and high economic efficiency of chorion and placenta studies as against other methods of prenatal diagnosis, great role in a decrease of prenatal disease and mortality are confirmed.