[Hepatoprotective effect of deanol aceglumate on experimental stress-induced gastropathy and diabetes mellitus].

Experiments on mice with streptozotocin-induced diabetes mellitus and stress-induced erosive ulcerous damage of the mucous membrane of stomach showed evidence of the preventive activity of deanol aceglumate in the course of peroral introduction at a dose of 250 mg/kg per 24 h during 4 days. This effect is accompanied by activation of the peristalsis of bowels and by an increase in the blood flow in the wall of stomach.

[Dysbiotic manifestations during eradication therapy of Helicobacter pylori and their corrections].

Forty-eight patients with duodenal peptic ulcer disease infected with Helicobacter pylori were examined. All patients undergo conventional 1-week eradication therapy. After its ending the patients were randomized to two groups: those who will be treated by synbiotics or control group. Normoflorin B and Normoflorin L, which contain bifidobacteria or lactobacilli in complex with different microelements, vitamins, aminoacids, organic acids, and antioxidants, were used as synbiotics. Morphologic study of biopsy samples of small intestine mucosa were performed in patients from both groups. It was determined that eradication therapy worsened existing symptoms of dyspepsia in 80.9% of cases or lead to their emergence, connected with dysbiotic manifestations, in 55.5% of patients. Inclusion of synbiotics in complex therapy resulted in rapid and effective elimination of dyspeptic symptoms, promoted recovery of affected morphologic and functional states of small intestine mucosal epithelium, and optimized metabolic processes important for the digestion.

[The electrophoretic mobility of peripheral blood lymphocytes in patients with tuberculosis of the lungs]. / Elektroforeticheskaia podvizhnost' limfotsitov perifericheskoi krovi bol'nykh tuberkuleznom legkikh.

The monitoring of the immune system in pulmonary tuberculosis patients and their peripheric blood lymphocyte reaction to its T-system modulators was undertaken by cellular electrophoresis. It was shown that when the lymphocyte subpopulation ratio tends to be normalized in vitro by inoculation with thymalin and T-activin, the given situation can be viewed as an indication to prescribe immunocorrection drugs to these patients. The lymphocyte subpopulation ratio check in the pulmonary tuberculosis subjects by means of the proposed method before and after the thymalin and T-activin treatment made it possible to reveal a significant normalization of the immunologic indices and to achieve better clinical condition of the patients.