[The gastroprotective action of acidic mineral water from the Azhyg-Sug source on the stress-induced injuries to the stomach of white rats]. / Gastroprotektivnoe deistvie kisloi mineral'noi vody istochnika Azhyg-Sug pri stress-indutsirovannom povrezhdenii zheludka u belykh krys.

BACKGROUND: The relevance of this study is determined by the need for the scientifically sound substantiation of the possibility for the use of acidic mineral waters in the treatment of digestive diseases taking into consideration their widespread application in ethnomedicine, in particular in the Republic of Tuva. AIM: The objective of the present study was to elucidate the gastroprotective action of acidic mineral water from the Azhyg-Sug source (Republic of Tyva) on the experimental animals as exemplified by the model of ulcerogenesis under the conditions of immobilization stress. MATERIAL AND METHODS: The experimental studies were carried out with the use of 32 white rats of the Wistar line. Ulcerogenesis was initiated by means of immobilization stress. We evaluated the pathomorphological characteristics of the gastric mucosa and the number of destructions based on the Pauls index. The state of the lipid peroxidation system and antioxidative protection were determined from the content of malon dialdehyde and reduced glutathione, extracellular catalase and superoxide dismutase activities in erythrocytes. RESULTS: The study has demonstrated that the mineral water from the Azhyg-Sug source slows down the development of the inflammatory and destructive necrotic processes in the mucosa of the stomach of albino rats. The depth of erosion in the animals receiving mineral water was 2.3 and 3.4 times lower than in the control animals (p≤0.05). The antioxidant effect of mineral water was confirmed by the 14-20% decrease of the MDA concentration as well as by the increase of the catalase and superoxide dismutase (SOD) activities by 21-25% and 20-30% respectively in comparison with the control animals. CONCLUSION: The Azhyg-Sug mineral water has the strong gastroprotective influence on the experimental animals having the induced neurogenic ulcer. One of the mechanisms underlying the gastroprotective action of the investigated mineral water arises from its ability to inhibit the processes of lipid peroxidation with the simultaneous enhancement of the activity of the antioxidant system of the organism.

[Treatment of chronic viral hepatitis C with direct acting antiviral agent: review].

HCV infection treatment regimens are viewed from positions of HCV life cycle and replication, effects of NS3/4A protease inhibitors and NS5A/NS5B inhibitors on HCV strain replication. Evolution of HCV treatment regimens from its discovery to modern DAA agents had led to substantial progress although drug resistance poses a new issue to be addressed.

[Antimutagenic and antioxidant features of confectionery products containing the powder from the leaves of Hippophae rhamnoides L.]

The aim of the work was to determine the possibility of using the powder from the leaves of Hippophae rhamnoides L. for enriching flour confectionery and to evaluate the antimutagenic and antioxidant activity of the product. The experiment was carried out on 24 white Wistar rats with initial body weight (b.w.) 180-200 g. The animals of the experimental group (n=8) received confection containing sea buckthorn powder at a rate of 20 mg per 100 g b.w. for 14 days on the background of a standard vivarium diet. The animals of the control and intact groups received confection containing no bioactive supplement at the same dose. Antimutagenic and antioxidant effects were estimated in a day after a single injection of cyclophosphamide at a dose of 20 mg/kg b.w. The number of chromosomal aberrations in bone marrow cells of white rats was counted and the activity of catalase, superoxide dismutase (SOD), the level of reduced glutathione and the concentration of TBA-active products in blood were evaluated. The intake of the confectionery containing the powdered H. rhamnoides leaves resulted in the 45% decrease of the number of damaged cells, 50% decrease of the proportion of cells with multiple chromosome breaks and 52% decrease of the number of achromatic gaps as compared to animals of the control group (n=8). The cake intake increased the activity of catalase (by 52%) and SOD (by 33%) and glutathione content (by 26%) in blood.

DETOXIFICATION AND DESENSITIZATION OF THE BODY IN THE TRADITIONAL MEDICINE / Монголын эм зүй, эм судлал

The present work presents information on the development and use of technologies for detoxification and desensitization of the body based on the tenets of the traditional medicine.KEY WORDS: traditional medicine, purification of the body, development and use, technology for detoxification and desensitization.INTRODUCTIONIn recent decades it has been noted the decrease in the index health as well as the incidence rate growth due to the deterioration of environmental conditions, the increased fastness of living, and the reduction of social protectability [7]. Pollution of the inner medium of the body with substances received through water, food and air causes a serious worry. These substances include plant and animal growth stimulants, fertilizers, pesticides, various coloring matters for foodstuffs, preservatives, drugs, salts of heavy metals, radionuclides, etc. Intensive xenobiotic contamination gives rise to dangerous acute intoxications and the development of chronic intoxication of the body followed by the disturbances of inner organs functioning resulting in the decrease of the bodily resistance and growth of incidence rate [2, 3]. Growing environmental and social pressing leads to the impairment of detoxification, desensitization, immune and other adaptive mechanisms of the human body [4, 5] that is a cause of many diseases. According to the data of World Health Organization (WHO) there is a tendency to the development of severe chronic cases due to intoxication and sensitization of the body [7]. Under the circumstances when the rate of chronic cases increases in number and the future generations are threatened with chronic diseases, the detoxification of the body seems of great importance.THE AIM of the given work is to develop and introduce into practice the detoxification and desensitization technology based on the traditional medicine.THE OBJECTS for studies were plant remedies stimulating detoxification and drainage function of the hepatobiliary system, gastro- intestinal tract, kidneys and skin created on the base of the traditional medicine formulae (nor bu dun thang, shi rguid, nephrophyt, sudorific plant collection). The studies were carried out with the use of pharmacological, clinical, biochemical and statistical methods [1, 6].RESULT. The lymphatic system is known to be the main drainage system excreting endo- and exotoxins from extracellular space, from cells and tissues [2, 3]. The system is capable to transport even big structures (high-molecular proteins, toxins) which enter the system through valves but not through semi-impermeable vessel walls as in the case of circulatory system. As a result transported toxins enter the venous duct. Further, the processes of detoxification take place mainly in the liver and kidneys. To avoid the “overloading” of these organs it is necessary to increase their functional activity using relevant medicinal preparations [4, 5, 7]. The increase in functioning of the given organs and drainage are regarded as the first level of detoxification and desensitization of the body. At present, taking into account the chemization of the home, water, air and food pollution and uncontrolled intake of medicinal preparations, it is necessary to pay attention to the “medicine of evacuation” i.e. to the purification of inner medium of the body [1, 5]. The technology for detoxification and desensitization of the body developed on the base of the traditional medicine, suggests the stage-by-stage intake of the remedy stimulating hepatobiliary system (nor bu dun thang) for 9 days; the remedy promoting the function of gastro-intestinal tract (shi brguid) for 9 days; the remedy stimulating the function of kidneys(nephrophyt) for 9 days and sudorific remedy (sudorific plant collection) for 9 days. Pre-clinical studies which were carried out on white male Wistar rats have revealed drainage and detoxification influence of the given remedies. The combined administration of the above remedies to SBA mice has shown that they have desensitization effect. Clinical studies of the given technology were carried out on the patients with endogenic intoxication and pollution of the inner medium of the body, particularly, on the persons suffered from atopic dermatitis and eczema. The Table 1 shows the results of therapy with the use of the developed technology of detoxification and desensitization of the body. The clinical studies were carried out on the patients suffered from allergic dermatoses (atopic dermatitis, eczema) at the Buryat Republican dermato-venerologic dispensary.The data given in the Table 1 show that the use of the given technology of detoxification and desensitization of the body improves the general state of the majority of patients followed by normalization of biochemical indices in the blood serum. Biochemical investigations performed after treatment have shown the decrease of the malonic dialdehyde (MDA) content and circulating immune complexes (CIC); the transaminase activity and concentration of α and α2 –globulins were also decreased as compared with the data obtained before treatment. The same tendency was observed in patients with the subacute stage of atopic dermatitis. Only in 5 patients no significant effect was noted. When the given technology was used for the treatment of eczema no significant positive changes in biochemical indices of the blood serum were noted in 32 cases in spite of satisfactory general state of the patients on the background of the treatment.The studies conducted have revealed the tendency to the improvement of the general state of the patients and the improvement of biochemical indices in the blood serum at the final terms of the treatment with the use of the given technology. Nevertheless in some cases a full health restoration was not noted in a number of patients, especially in patients with eczema. It is indicative of probable recurrence of the disease. Refresher course of the treatment is advisable.

CHOLERETIC PLANT REMEDIES OF THE TRADITIONAL MEDICINE AND PROSPECTS OF THE CREATION OF NEW PREPARATIONS ON THEIR BASE / Монголын эм зүй, эм судлал

25 species of plants from Transbaikalian flora possess choleretic activity in a varying degree depending on the doses used. Choleretic activity was revealed in multicomponent remedies and xanthone compounds from Gentianaceae family.Key words: bile, plant mono- and complex plant remedies, xanthone compounds.IntroductionMedicinal plants were used as choleretic remedies since ancient times. In particular these plants are widely used for the treatment of digestive organs diseases which have the tendency to chronization and require complex long-term pharmacotherapy.The objective of the present work was to estimate the choleretic activity of the plants used for the treatment of hepatobiliary diseases in the traditional medicine.There were studied the decoctions from the aerial part of Lomatogonium carinthiacum, Gentianopsis barbata, Gentiana macrophylla, Halenia corniculata (Gentianaceae), Trifolium lupinaster, Parnassia palustris (Saxifragaceae), Leptopyrum fumarioides, Odontites rubra (Scrophulariaceae), Artemisia scoparia, Crepis tectorum (Asteraceae), Arctostaphylos uva-ursi (Ericaceae), Pyrola rotundifolia (Pyrolaceae), flowers of Vincetoxicum sibiricum (Asclepiadaceae), Hypecoum erectum (Papaveraceae), Hemerocalis minor (Liliaceae), branches of Myricaria dahurica (Tamaricaceae), leaves of Vaccinium vitis-idaea (Ericaceae), and fruits of Crataegus sanginea (Rosaceae).Besides there were studied the extracts from Trifolium repens (Fabaceae), Phlomis tuberosa (Lamiaceae), Pentaphylloides fruticosa, Polygonum aviculare (polygonaceae), Pedicularis verticillata, Linaria vulgaris (Scrophylariaceae) and Bergenia crassifolia (Saxifragaceae).Materials and methodsThe experiments were carried out on white male and female Wistar rats. The bile was obtained according to the generally accepted method [1] with the use of polyethylene cannula inserted into the common bile duct of the rats under barbamyle narcosis (0.8 ml per 100 g of weight, intraperitoneally). The bile was collected every hour for 5 hours. The power of choleretic activity of the obtained extract was estimated according to the secretion rate and total amount of the bile secreted as well as according to the content of the main ingredients in the bile, namely bilirubin [2], bile acids and cholesterol [3]. The decoctions were studied at the doses from 10 to 1000 mg/kg of the animal weight (on air-dry basis). The rats of the control group received the same volume of purified water. The data processing was performed with the use of the Student’s t-criterion.

CHOLERETIC EFFECT OF THE EXTRACT FROM CALENDULA OFFICINALIS / Монголын эм зүй, эм судлал

Choleretic activity of Calendula officinalis extract and its butanol fraction was studied and the results are presented in the given paper. It has been established that the choleretic effect of the extract from this plant is due to biologically active substances predominantly contained in its butanol fraction.Key words: extract of Calendula officinalis, butanol fraction, choleretic effect.Introduction The use of medicinal plants both wild-growing and cultivated ones for the correction of impaired functions of the human body remains topical. The plants are the optimal source of cholagogues as they are harmless or low-toxic and have no side effects in long-term use [1]. Particularly, Calendula officinalis L. (Compositae) is of great interest. It is an annual grassy plant cultivated in many regions of Russia.The aim of the present work was to determine choleretic activity of the extract from Calendula officinalis and its butanol fraction.Materials and methodsThe dry extract was derived from Calendula flowers by extraction with 60% alcohol. The study of butanol fraction (BF) composition of the given extract was carried out with the use of microcolumn RP-HPLC-UV [2, 3]. The obtained fraction yield was 35-40% of the total dry extract mass.Experiments were carried out on white male Wistar rats weighing 170-200g. The bile was obtained from rats under thiopental sodium narcosis in accordance with the standard method (40 mg/kg of the weight, intraperitoneally). The bile was collected every hour for 4 hours. The power of choleretic activity of the obtained extract was estimated according to the secretion rate and total amount of the bile secreted as well as according to the content of the main ingredients in the bile, namely bilirubin [4], bile acids and officinalis was introduced into duodenum of experimental animals at three doses: 50, 100 and 200 mg/kg of the rat weight and the butanol fraction – at the dose of 50 mg/kg. The animals of the control group received purified water in the same volume. The significance of differences between parameters across the groups was estimated with the use of U distribution-free test by Mann-Whitney.ResultsThe data obtained are given in Table 1-2. The introduction of the Calendula dry extract to the rats at the dose of 50 mg/kg increases the bile secretion rate by 16% and in the next hours of the experiment – by 37.5 and 44%. The increase of the dose up to 100 mg/kg induced more marked stimulation of choleretic reaction in rats. The bile secretion rate increased by 28, 35 and 44% in 2-4 hours of the experiment respectively followed by the 35% increase of the total volume of secreted bile. When the extract was administered at the dose of 200 mg/kg the bile secretion rate exceeded the control data by 33 and 36%. Under the influence of the Calendula extract the choleretic reaction lasted during the whole period of the experiment. Besides, the Calendula extract at the given doses influenced the stimulation of synthesis and excretion of cholates with bile that was more marked at the dose of 100 mg/kg. The introduction of the butanol fraction in the given dose increased the bile secretion rate by 27, 47 and 44% respectively in 1-3 hours after the administration; the total volume of secreted bile was 39% increased. The sum concentration of bile acids in the bile exceeded this index in rats of the control group by 16%. The cholesterol content in the bile exceeded the given index in animals of the control group by 55%.

CHRONIC TOXICITY ASSESSMENT OF HIPOLIPIDAEMIC HERBAL EXTRACT / Монголын эм зүй, эм судлал

Aim of the study: The present study was car- ried out to evaluate the safety of a hipolipidaemic herbal extract by determining its potential toxicity after chronic administration in rats.Materials and Methods: The hipolipidaemic herbal extract was administered orally at doses of 50, 150 mg/kg daily for 90 days to rats. Bio- chemical and morphological parameters were determined after 90 days of daily administration. Results: In the chronic study in rats, daily oral administration of the extract for up to 90 days did not result in death or significant changes in the biological, biochemical and morphological parameters. Conclusions: The results showed that the hypolipidaemic herbal extract had no toxicity in oral chronic administration and indicate that the herbal formula could be considered safe for oral medication. Key words: Herbal hypolipidaemic extract, chronic toxicity. Introduction In the present time, there has been a great in- crease in the use of herbal remedies in the treat- ment of diseases [1, 2]. Many traditional plants with therapeutic lipid-lowering properties are claimed to be useful in the treatment of hyperlipi- demia and associated pathologies [3, 4, 5]. The hipolipidaemic herbal composition (extract) con- sists of ten herbs: fruits of Rosa canina L., Cra- taegus sanguinea Pall., Elettaria cardamonum L.and Malus baccata L., roots and rhizomae of Glycyrrhiza glabra L., Zingiber officnale, såminà Lini usitatissimi L., folia Îrthosiphoni staminei Benth. and other. Chronic toxicity study of this hipolipidaemic herbal extract was performed in rats in order to evaluate the safety. Material and methods Wistar rats of both sexes aged 1-1.5 months toxicity assessment. Animals were divided into 3 groups (I–III) of 10 each (5 females and 5 males). The extract, dissolved in distilled water, was ad- ministered by daily oral for 90 days, to rats of groups II-III (doses of 50, 150 mg/kg, respec- tively). I group was control (distillate water). The animals were observed for signs of toxicity and mortality throughout the experimental period. The body weigh were recorded weekly. At the end of the 90-day experiment, rats of each group were sacrificed by decapitation under anaesthe- sia (sodium thiopental 50 mg/kg). Blood was col- lected for biochemical studies respectively. The organs (brain, heart, lung, liver, spleen, kidneys) were weighted and compared with the value of control. Organ samples (kidney, pancreas, lung and liver) were fixed in 10% formalin for histo- pathological examination.

[Hepatoprotective effect of Hypecoum erectum extract on experimental D-galactosamine-induced damage of rat liver].

Hepatoprotective properties of the extract derived from the herbs of Hypecoum erectum L. have been studied on a model of D-galactosamine-induced hepatitis in rats. It is established that Hypecoum erectum extract in a dose of 50 mg/kg diminishes the development of cytolysis and cholestasis syndromes, as manifested by maximum decrease in the following indices after 7 days of the experiment: ALT activity by 26%; AST activity by 44%; alkaline phosphatase activity by 30%; ß-lipoproteins by 21%; and bilirubin by 29% (p < 0.05). The Hypecoum erectum extract (i) increases the energy potential of hepatocytes, manifested by increasing the ATP content by 70% (p = 0.001) and normalizing the ratio of lactate and pyruvate in the liver homogenate; (ii) inhibits lipid peroxidation, manifested by decreasing the content of malonic dialdehyde in the liver homogenate and diene conjugates in the blood serum on the average by 30% (p < 0.05); (iii) activates the antioxidant system of the organism, increasing the catalase activity in liver homogenates by 58% (p < 0.05) and 11% and the content of reduced glutathione in the blood by 56% (p < 0.05) and 36% (p < 0.05), respectively, on the 3rd and 7th days of the experiment.

[Effect of Hypecoum erectum extract on morphofunctional state of the liver in rats with tetracycline-associated hepatitis].

The effect of Hypecoum erectum L. extract on the morphofunctional condition of the liver in rats with experimental tetracycline-associated hepatitis was studied. The experiment included 40 albino rats Wistar. The animals treated with tetracycline hydrochloride (1.0 g/kg body weight) were exposed to the extract in a dose of 50 mg/kg for 5 days. On the 7th day of the experiment the following indices were determined: malonic dialdehyde concentration, catalase activity, the levels of ATP, pyruvate and lactate in the liver homogenate, as well as the blood levels of reduced glutathione. The liver pathomorphological investigation was applied. The H. erectum extract was shown to inhibit lipid peroxidation, to increase the activity of the host endogenous antioxidant system, to normalize the hepatocyte energy provision and to limit the liver degeneration.

[The choleretic and hepatoprotective effect of Hypecoum erectum extract].

The choleretic and hepatoprotective effect of Hypecoum erectum L. dry extract on toxic hepatitis was studied. Experimental hepatitis was caused by the introduction of D-galactosamine to Wistar white rats in the dose of 500 mg/kg of the animal weight once a day for 3 days. The H. erectum extract was administered per os in the dose of 50 mg/kg for 7 days. It has been established that H. erectum extract has a marked hepatoprotective effect in the case of D-galactosamine hepatitis in white rats that is characterized by inhibition of the disturbances in cholate-synthetic functions of the liver, increase of bile secretion rate, preservation of cholate concentration in the bile. The tested remedy diminishes dystrophic and necrotic processes, decreases the intensity of inflammatory infiltration in the liver and stimulates regeneration of liver cells in D-galactosamine hepatitis.

[Effect of Leptopyrum fumarioides (Ranunculaceae) extract on choleresis in white rats with toxic hepatitis].

It was established pharmacotherapeutic efficiency of Leptopyrum fumarioides (L.) Reichenb. dry on the toxic hepatitis model. The Leptopyrum fumarioides extract was shown expressed caused of inhibiting of cholerforming and choleretic function of liver and their destructive changes.

Hepatoprotective activity of multicomponent herbal drug “adapton 6” / Монголын Анагаах Ухаан

Introduction: A number of risk factors predispose an individual to hepatic drug Thus, there is need to develop a effective hepatoprotective formulation which could reduces of such liver complications caused due to hepatotoxic agents etc. The present work was focused on the investigation of hepatoprotective activity of various herbal formulations “Adapton 6” containing aqueous as well as hepatoprotective crude drugs. The herbal drug ingredients of Astragalus membranaceae (Астрагала перепончатого), Rhaponticum cartamoides (левзеи), Rheum palmatum L (ревеня), Rosa cinnamomea (плоды шиповника), Crataegus sanguine Pall (боярышника) and Hippophae rhamnoides L (облепихи) Purpose: The present study aims to examine the effects of Hepatoprotective activity of multicomponent herbal drug “Adapton 6”Materials and Methods: The hepatoprotective effect was studied further in rats, using carbon tetrachloride (CC!4)-induced hepatotoxicity as in vivo model. The Hepatoprotective activity of “Adapton 6” were evaluated and compared statistically after inducing hepatotoxicity in rats by intraperitonally administration of carbon tetrachloride (CCL4) with olive oil 50% as a diluent in 3 times 1 day. The liver damage was confirmed by estimation of elevated levels of cytoplasmic enzymes Serum Glutamate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Alkaline Phosphatase (ALP), serum bilirubin and malondialdehyde (MDA), hydroperoxides, glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT).Result: On intraperiteonally administration of CCl4 in dose of 100 mg/kg produced acute hepatic damage in positive control (carbon tetrachloride treated) when compared with normal control. In treats groups, formulations “Adapton 6” were administered simultaneously with CCl4. Estimated levels of enzymes SGOT, SGPT, SALP and bilirubin in test groups were compared with levels of enzymes in normal, control groups. These show hepatoprotection effect but other due to antioxidant effects like exist of malondi-aldehide and catalase (CAT) activities.Conclusion: On conclusion, the prepared multicomponent herbal drug “Adapton 6” has demonstrated a very good hepatoprotection against the CCl 4 induced liver damage.

[Anti-inflammatory effect of seven-component herbal tea "Narkophyt"].

Experiments showed that a seven-component herbal mix decoction Narkophyt possesses anti-inflammatory properties, as manifested by the inhibition of exudation, reduction of the permeability of blood vessels, and decrease of fat cells degranulation.

[Technology of production and biological activity of toothpaste from Rubus idaeus].

Composition and the technology of manufacturing of toothpaste from extract of blackberry with anti-inflammatory activity have been developed. Toothpaste contains the following ingredients (g): Blackberry extract - 3.0 5.0 7.0 Aluminum hydroxide - 30,0 Glycerin - 10,0 Sodim carboxymethylcellulose - 1,5 Sodium laurilsulfate - 2,0 Calcium glycerophosphate - 1,5 Sodium monofluorophosphate - 1.0 Titanium dioxide - 1,0 Perfume - 1,0 Sorbit - 1,0 Purified water to 100 ml. Toothpaste containing 3%, 5% and 7% of blackberry extract possesses higher antioedemic activity and has mild influence on alteration and proliferation processes. This allows us to recommend researched toothpaste for application.

[Influence of Gentiana lutea L extract on blood coagulation].

The dry extract from the terrestrial parts of Gentiana Lutea was received in accordance to the developed by us general technological scheme. Study of the pharmacological influence of obtained extract on the coagulating properties of blood revealed that after its per os instillation into experimental animals the time of the formation of active thromboplastin reliably increases, while the time of thrombin and fibrinous cluster formation is shortened in comparison with those indices in the animals, that did not receive phyto-preparation, at the same time morphological appearance of the peripheral blood remains unchanged. Dry extract of terrestrial parts of Gentiana Lutea prepared in accordance to the technology recommended by us, together with widely known pharmacological effects, is characterized with new activity - influence on haemostasis. Obtained preliminary data concerning influence of the extract on coagulation of the blood request further deep studies of its mechanism. Revealed new activity of the terrestrial parts of Gentiana Lutea and the studies of the mechanism of its activity will serve in future as a basis for the recommendation of its use in new nosology. Terrestrial parts of Gentiana lutea L. are proposed as an alternative of the underground parts of the plant. Alongside with that, it is expedient to continue the studies devoted to the development of the haemostatic remedies of plant origin with systemic and local action (sponges, films, skin glues) from terrestrial parts of Gentiana lutea L.

[Creation of phytovaleologic drugs].

This is a new field of knowledge in medical sciences that means "Healthy Way of Life". Based on the data of medical plants and on the results of Phytochemical and Pharmacological studies, carried out in preliminary experiments, there are cultivated compositions of Valeological substances, potentially having radio protective activity. As the basis for the selection of raw materials and their correlation in mixture, there were taken the data of spontaneous analysis of chemical composition having pharmacological (radio protective) activity of various compositions. As the result, the types of studied raw materials and their parties by weight in total mixture have been defined: Valeological substances 1: 1. Tea (leaves); 2. Common plantain (leaves); 3. Horse gowan (flowers); 4. Blackberry (leaves) 5. Hips; 6. Peppermint (leaves). Valeological substances 2: 1. Tea (leaves); 2. Dandelion (leaves); 3. Horse gowan (flowers); 4. Knotgrass (herbage); 5. Hips; 6. Peppermint (leaves) Experimental studies revealed that the most optimal way of brewing tea is rational method. Valeological substances 1 and 2 (tea with radio protective activity) "Protector" and "Adjara" - correspondingly. Technical conditions and technological instructions for radio protective tea "Protector" and "Adjara" are created. Pharmacological studies of tea "Protector" and "Adjara" have taken place in the Branch of Biological University of Buryatia (Academy of Science of Russian Federation) under the supervision of Prof. S. M. Nikolaev. Radio protective teas "Protector" and "Adjara" is approved by the Ministry of Health Sciences.

[Radio protective drug production from fresh leaves of Aloe arborescens Mill].

Nowadays, phytogenous drugs are wildly used as radio protective substances. The aim of the research was to study radio protective characteristics of aloe juice fraction and to develop new technology for radio protective drug production. Technological scheme for getting the drug in two stages. The first stage - extraction of juice from fresh leaves; the second stage - extracting bagasse have been developed and optimal environment for bagasse extraction are defined: Infusion of bagasse with 96 % ethyl spirit (1:1) during 30 minutes, continuation of extracting with water on correlation to raw materials 10:1 at temperature of 70 degrees C during 30 minutes. For the basis of the first series of balanced loading there are taken the optimal parameters of extracting process, on the basis of which in its turn was developed technological scheme of getting dry extract of aloe. Dry extract is a fine-dispersed reddish-yellow (brownish-yellow) powder, which can be easily dissolved in warm (40-60 degrees C) water. Pharmacological researches were conducted in the Institute of General and Experimental Biology, Siberian Branch, Russian. Academy of Sciences. The remarkable radio protective effect of the drug was revealed.

[Hypolipidemic, anti-oxidant and anticoagulant action of camphor-25 compound].

Pharmacotherapeutic efficacy, anti-oxidant and anti-coagulant activity of camphor compound was tested in animals with experimental dyslipoproteinemia. Positive results of the experiment allows recommending this compound for prevention of an atherosclerotic damage of vascular endothelium and against thrombogenesis.

[Hepatoprotective effect of hepatophyt in experimental drug hepatitis].

The hepatoprotective action of Hepatophyt was studied on Wistar rats with experimental hepatitis caused by exposure of the animals to tetracycline. Hepatophyt was administered per os in a dose of 0.1 g/kg. Its significant pharmacotherapeutic action was due to the content of biologically active substances, mainly of polyphenol nature. As natural antioxidants, they provided stabilization of the biomembranes and increased the energetic potential of the hepatic cells and the contractile capacity of the pericanal microfilaments, thus stimulating the synthesis and transport of the cholates and excretion of bilirubin and cholesterol with bile.

[Phytocorrection of structural changes in the gastrointestinal tract caused by 6-mercaptopurine].

It was shown that the course use of Ventrofit, a complex plant remedy, normalized the structural and functional integrity of the stomach and thin intestine mucous membranes damaged by the use of 6-mercaptopurine.