[The combined use of peptide bioregulators and self-massage in order to improve the psychophysiological state and increase the professional performance of the elderly.]

The development of modern society is characterized by an increase in the volume and changing forms of information presentation. In the works of Russian and foreign gerontologists, it is noted that the perception and analysis of the flow of relevant data today causes difficulties for a significant part of citizens of older age groups, which is due, among other things, to the deterioration of their psychophysiological state. The lack of the ability to use the necessary information negatively affects the quality of life, the level of social adaptation and professional competence. This problem is particularly significant for population groups and professional communities, whose life and activities require the actualization of certain sectors of the information field. Typical examples of such groups are citizens of retirement age who continue professional activities related to the mobilization of intellectual and creative potential, in particular, university teachers. The use of gerontotechnologies contributes to solving the problem, which provides for the development of effective methods for correcting the functional state of elderly citizens, in particular, increasing the ability to perceive information and the level of vital activity. This publication presents the results of an experimental study of the effectiveness of the combined use of peptide bioregulators and massage on the level of professional performance of elderly teachers of a pedagogical university.

[Risk factors influencing the development of gastroduodenal bleeding].

Bleedings of an ulcerative aetiology are an actual and multiplane problem many years. Obvious communication of the complicated current of a peptic ulcer with various risk factors, such as a tobacco smoking, abusing alcohol, uncontrolled and long reception of ulcerogenic agents (NSAID, anticoagulants etc.), mucosa of stomach H. pylori, is noted by a serious accompanying pathology of other organs and systems. The knowledge of influence of interaction of the facts of risk on development bleedings of an ulcerative aetiology, will allow to develop in due time the complex of medical actions referred on prevention of this terrible complication.

[Experience in studying antigenic activity of inactivated hepatitis A vaccine]. / Opyt izucheniia antigennoi aktivnosti inaktivirovannykh vaktsin protiv gepatita A.

The results obtained during the study of antigeneity of inactivated vaccines against hepatitis A ("Avaxim", France; "Hep-A-in-VAC", Russia; "Havrix", Belgium) used in troop units and RF MD institutions are presented in the article. The aim of the investigation is choice of the drug that provides the production of antibody protective levels in maximally short periods. It is very important for the army collectives sent to the zones of armed conflicts and HAV epidemic centres. It is shown that the most acceptable vaccine is "Avaxim" that provides the highest percentage of seroconversion (93.75%) with antibody level not less than 125 mIU/ml. It is recommended to consider this level as the protective one in conditions of army collectives.

[Outbreak of hemorrhagic fever with kidney syndrome in Egor'ev district of Moscow region]. / Analiz vspyshki gemorragicheskoi likhoradki s pochechnym sindromom v Egor'evskom raione Moskovskoi oblasti.

Epizootological, serological, and molecular virological analysis of an outbreak of hemorrhagic fever with renal syndrome (HFRS) in the Egoryevsk district of Moscow region (September 1995-January 1996) has been carried out. Hantavirus (Puumala) antigen and virus-specific antibodies were isolated from bank voles captured in the endemic focus. Anti-Puumala antibodies were detected in the sera of all HFRS patients and in 2% healthy residents of the endemic focus. Analysis of nucleotide sequence (RNA from hantavirus-positive lung of a bank vole) showed that the studied hantavirus is a distinct genotype of Puumala virus. Hence, a new highly active natural focus of HFRS associated with Puumala virus, dangerous for the population, has been revealed in Moscow region.

[Relationship of vascular reactivity to blood lipid spectrum and lipid peroxidation in unstable angina]. / Sootnoshenie sosudistoi reaktivnosti s lipidnym spektrom krovi i sostoianiem perekisnogo okisleniia lipidov pri nestabil'noi stenokardii.

AIM: To examine the relationship between the vascular response of the microcirculatory bed to vasoactive agents and lipid peroxidation (LPO) and antioxidative defense in patients with unstable angina pectoris. MATERIALS AND METHODS: Thirty male patients (mean age 58.0 +/- 2.4 years) were examined. The patients were divided into 2 groups: 1) those with high alpha-cholesterolemia alone and 2) those with high alpha-cholesterolemia concurrent with hyperglyceridemia and elevated total cholesterol levels. Photoplethysmographic determination was used to evaluate vascular responses to norepinephrine (vasopressor function) and histamine (vasodilating function), the blood levels of cortisol, LPO products, antioxidative protection components, histamine, and serotonin. RESULTS: Vascular dilating function was found to be most pronounced in Group 1. Moreover, Group 1 patients had a significant depression of the antioxidative defense system and the highest blood levels of cortisol, and serotonin. The levels of LPO products did not differ significantly in both groups though they were significantly higher than those in healthy individuals. CONCLUSION: Impairment in the antioxidant system and in coordination of vasodilating function to histamine stimulation are typical of patients with unstable angina.

Relationships between left hemisphere predominance and disturbances of lipid metabolism in different ethnic groups.

The purpose of this study was to analyze the relationships between brain hemisphere predominance and disturbance of lipid metabolism in atherosclerosis in different ethnic groups. Three groups of subjects were examined: 52 healthy Selkups (the isolated ethnic population of the Far North), 50 healthy Russian men, living in Novosibirsk, and 78 Russian men, living in Novosibirsk, who had myocardial infarction before the age of 50. Blood cholesterol, low density lypoprotein (LDL) and high density lypoprotein (HDL) levels of the subjects with different brain functional asymmetry were compared. The lack of either hemisphere predominance is the most common among the Selkups. The population of Selkups as a whole showed low concentrations of cholesterol and LDL in comparison with both Russian groups. For all examined groups the pattern of lipid metabolism has been worsened for the subjects showing the left hemisphere predominance. The changes of lipid metabolism indices in subjects with the dominant left hemisphere is discussed.

Prognosis of myocardial infarction and brain functional asymmetry.

Seventy-eight men (mean age, 47.0 +/- 1.1 years) who had suffered from myocardial infarction were examined. Blood cholesterol, lipoproteins, triglycerides, insulin and cortisol concentrations were compared in patients with left hemisphere or right hemisphere cerebral dominance. Patients with left hemisphere dominance had more serious disease and much higher levels of blood cholesterol and lipoproteins. Patients with right hemisphere dominance had the highest levels of blood cortisol and insulin. The brain's functional asymmetry may be one of the risk factors for coronary atherosclerosis in subjects under the age of 50 years.

[Functional sensory and motor asymmetry profile in patients with neuroses and those with diseases of the digestive system]. / Profil' funktsional'noi sensomotornoi asimmetrii u bol'nykh nevrozom i lits s zabolevaniiami pishchevaritel'noi sistemy.

Functional sensorimotor asymmetry (FSMA) was analyzed in 21 healthy volunteers, 19 neurotic patients and 29 patients suffering from alimentary diseases. Among the neurotic patients, there prevailed those with the left profile of FSMA as compared to the group of healthy persons. As to the group of the patients with alimentary diseases, a subgroup of persons with no disturbances of emotional information perception by the neurotic type was distinguished according to the psychophysiological characteristics. Among those persons in the given representative sample, none showed the left and symmetric profiles of FSMA.

[The sensitizing properties of the ballast admixtures in human leukocyte interferon]. / Izuchenie sensibiliziruiushchikh svoistv ballastnykh primesei chelovecheskogo leikotsitarnogo interferona.

Due to the features of its production technology, human leukocyte interferon (HLI) for intranasal administration is likely to contain ovalbumin (OA). Commercial batches of HLI were tested for the presence of OA responsible for the sensitizing effect of HLI given intranasally. The content of OA in commercial batches of HLI was shown to vary widely and to exceed by far the concentrations having the sensitizing effect. As a result of these studies, the upper limit of OA content was established and the technology of HLI production was modified. These measures permitted production of commercial batches of HLI with OA content not exceeding 0.05 micrograms/ml.

[Analysis of the profiles of functional psychomotor asymmetry and mental stress in patients with cardiovascular diseases]. / Analiz tipov profilia funktsional'noi sensomotornoi asimmetrii i psikhicheskogo napriazheniia u bol'nykh s serdechno-sosudistymi zabolevaniiami.

The profile of functional sensomotor asymmetry (FSMA) was evaluated by a series of tests and inversion of emotional reflection. Altogether 70 healthy subjects and 114 cardiovascular diseases patients were examined. Among the patients there were 36 subjects with acute myocardial infarction, 28 with coronary heart disease, 26 with borderline hypertension and 24 with neurocirculatory dystonia (NCD). The highest emotional tension was recognized in myocardial infarction and coronary heart disease. NCD patients exhibit the left FSMA profile more frequently than healthy subjects.

[Weight gain during pregnancy in relation to somatic types of women]. / Pribavka massy tela vo vremia beremennosti v zavisimosti ot somaticheskikh tipov zhenshchin.

The paper presents findings on weekly weight gain in pregnant women as related to constitutional make-ups. Normal and apparently normal pregnant women who were followed up at an antenatal clinic from 7-8 to 40-41 week's gestation have been assigned at the beginning of pregnancy to three weight groups: normal body weight, excessive body weight due to increased fat deposition and deficient body weight. Anthropometric measurements at 7-8, 25-26 and 36-37 weeks showed that weight gain and fat accretion were highest in pregnancies with an initial deficient body weight and lowest in pregnant women with adiposity. Correlation analysis suggested that there was a relationship between the maternal body weight, gestational weight gain and neonatal birthweights. Since women with initial deficient body weights have a wider range of weight gain, as compared with other somatic types, dietary restriction counselling should be cautious and adequate.

[Use of the emotional reflection inversion test for detection of persons with high risk of development of neurotic disorders]. / Ispo'lzovanie testa inversii émotsiona'lnogo otrazheniia dlia vyiavleniia lits s vysokim riskom razvitiia nevroticheskikh rasstroistv.

The results of application of emotional reflection inversion test were juxtaposed to the data of psychiatric investigation of 133 subjects in an out-patient department. The test proved most efficient in detecting the neurotic responses ensuring emotional strain and nonadaptive attitudes. The test is simply used and recommended for mass prophylactic population screening.