[Morphological fibroblastic changes in cytomegalovirus infection].

Cytomegalovirus (CMV) infection is widely spread among population. While immunocompetent patients suffer rarely from this virus, it can lead to a lethal outcome in immunocompromised patients. An electron microscopic study has detected fibroblastic morphological changes of a definite cytodestructive character. The nuclei of some fibroblasts have chromatine condensation. A clear zone arising due to vacuolization near this inclusion may reflect nuclear rearrangement leading to further CMV metamorphosis of the cell. This metamorphosis is characteristic of the changes developing in the cells of different parenchymatous organs.

[Pathomorphogenesis of cytomegalovirus lungs lesions in HIV infection]. / Patomorfogeneziz tsitomegalovirusnogo porazheniia legkikh pri vich-infektsii.

Pathomorphologic characteristics of cytomegalovirus (CMV) lung damage in 18 patients who died of HIV infection are outlined. The following variants of lung lesions are distinguished: 1) CMV transformation of the cells in the respiratory compartments and tracts; 2) pneumonias with development of caverns with CMV transformed cells; 3) productive CMV alveolitis with granuloma formation; 4) pulmonary fibrosis and "adenomatosis" associated with CMV infection; 5) CMV transformed cells in secondary lesions--tumours and infections. Heterogeneous number and distribution of CMV cells at early stages, tumours and purulent foci were documented in CMV infections of the lungs.

[A morphometric study of the ultrastructure of the axosomatic synapses in the sensorimotor cortex of rats administered the delta-sleep inducing peptide]. / Morfometricheskoe issledovanie ul'trastruktury aksosomaticheskikh sinapsov sensomotornoi kory mozga krys pri vvedenii del'ta-son indutsiruiushchego peptida.

Qualitative estimation and quantitative morphometry of ultrastructural changes in layers III, IV, and V in rat sensomotorial cortex after delta-sleep-inducing peptide administration, provides an evidence of multiplication of active inhibitory synapses induced by DSIP. The newly activated synapses may form an axo-somatic synaptic pool participating in optimization of the balance of excitement and inhibition processes in sensomotorial cortex.

[Reparative processes in postischemic cerebral cortex in the early postresuscitation period (materials submitted to the International Symposium, "Central nervous system and postresuscitation pathology," Moscow, March 14-16, 1989)]. / Reparativnye protsessy v postishemicheskoi tserebral'noi kore v rannei postreanimatsionnyi period (Material dolozhen na Mezhdunarodnom simpoziume "Tsentral'naia nervnaia sistema i postreanimatsionnaia patologiia organizma", 14-16 marta 1989 g., Moskva).

Dynamics of neuronal plasticity in rat postischemic cerebral cortex in the early postresuscitation period following complete ischemia was studied by electron microscopic methods. In this period destructive processes have proved to run parallel with reparative ones in the postischemic cerebral cortex. The phenomenon of true regeneration of cell processes in the cerebral neurons engendering growth cones observed by the third hour of the post-resuscitation period is of particular interest. Subsequently, these signs lead to the formation of new synaptic interneuronal links and new neuronal nets in the cerebral cortex. The data obtained open up new prospects for understanding the pathogenesis of postresuscitation encephalopathies.

[Visual estimation of the glycogen content of liver cells with simultaneous statistical control]. / Vizual'naia otsenka soderzhaniia glikogena v kletkakh pecheni s tekushchim statisticheskim kontrolem.

Estimation is performed in stipulated units per every "probe" out of several hundreds, which are selected in randomly taken fields of observations by means of a special ocular grid. After discrete marks have been converted into continuous ones (by means of averaging per every 25 probes) confidential intervals and reliability of the mean mark are calculated.