RESUMO
The presence of a low T3 syndrome was confirmed in elderly euthyroid patients. The condition is characterised by lower circulating total (TT3) and free triiodothyronin (FT3) than in adults with no clinical symptoms of hypothyroidism. A total of 133 subjects over 65 were studied as we used 204 adult controls aged 18-65. Among the indices of thyroid function studied only TT3 and FT3 were founded to be statistically reduced among the elderly.
Assuntos
Tri-Iodotironina/deficiência , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Síndrome , Tireotropina/sangue , Tiroxina/sangue , Tri-Iodotironina/sangueRESUMO
Leukaemic blood lymphocytes from patients with B prolymphocytic leukaemia express the common acute lymphoblastic leukaemia antigen (CALLA). The in vitro incubation of prolymphocytes with leucocyte conditioned medium produced the acquisition of plasma cell morphology, of intracytoplasmic immunoglobulins and the simultaneous reduction of CALLA expression. The presence of CALLA appears to be unrelated to different clinical courses. Our report demonstrates that the antigen is present also in relatively mature stages of B lymphocyte differentiation. The blastic appearance of prolymphocytes could suggest that CALLA may be related to active metabolism or function of these cells.
Assuntos
Antígenos de Neoplasias , Linfócitos B/imunologia , Leucemia Linfoide/imunologia , Antígenos de Superfície , Diferenciação Celular , Humanos , Técnicas In Vitro , Neprilisina , Receptores de Antígenos de Linfócitos B , Fatores de TempoRESUMO
We describe 2 cases of T cell leukaemia. Both patients react with OKT 4 monoclonal antibody, while their clinical course, surface markers and in vitro immunological reactivity present opposite behaviour. The cells of 1 patient react with all pan T cell markers (OKT 3, OKT 11, Leu 1), from E and Ea rosettes and respond well to mitogens. This patient does not present liver, spleen or lymph node enlargement; white cell count is stable and no other haematological alterations are present. The cells from the 2 patient are unreactive with OKT 3 and are unable to form Ea rosettes. The response to mitogens is almost abolished. The disease has an aggressive clinical course with progressively increasing blood leucocyte count and infiltration of liver and spleen. These data suggest that the study of antigenic and functional properties of T CLL may be useful to better define the biologic characteristics and the prognostic criteria of the disease.
