RESUMO
In pathogenesis of the traumatic disease of the spinal cord, two mechanisms of the injuries of its neuronal apparatus are defined: primary (necrosis) and secondary (apoptosis). In the work a participation of a number of internal causes in the progression of apoptosis in injury of the spinal cord and peripheral nerve trunks, the role of those remains little-studied up to date, is discussed.
Assuntos
Apoptose/genética , Necrose/fisiopatologia , Traumatismos dos Nervos Periféricos/fisiopatologia , Nervos Periféricos/fisiopatologia , Traumatismos da Medula Espinal/fisiopatologia , Medula Espinal/fisiopatologia , Animais , Caspases/genética , Caspases/metabolismo , Citocinas/genética , Citocinas/metabolismo , Regulação da Expressão Gênica , Humanos , Necrose/genética , Necrose/metabolismo , Traumatismos dos Nervos Periféricos/genética , Traumatismos dos Nervos Periféricos/metabolismo , Nervos Periféricos/metabolismo , Proteínas Proto-Oncogênicas c-bcl-2/genética , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , Espécies Reativas de Oxigênio/metabolismo , Transdução de Sinais , Medula Espinal/metabolismo , Traumatismos da Medula Espinal/genética , Traumatismos da Medula Espinal/metabolismoRESUMO
Effects of direct long-term electric stimulation on the growth of the sciatic nerve regenerating axons through autoneurotransplants were studied in rabbits and an optimal electrostimulation method was developed.
Assuntos
Regeneração Nervosa/fisiologia , Nervos Periféricos/fisiologia , Nervo Isquiático/fisiologia , Animais , Axônios/fisiologia , Estimulação Elétrica/métodos , Neurônios/transplante , Nervos Periféricos/cirurgia , Coelhos , Reprodutibilidade dos Testes , Nervo Isquiático/cirurgia , Transplante AutólogoRESUMO
Biochemical changes are determined by the severity of craniocerebral injury. Twenty-four hours after the injury the activity of succinate dehydrogenase in lymphocytes increases significantly in patients with brain concussion and contusion of medium severity. Glutamate dehydrogenase activity increases in patients with repeated brain concussion. The content of malonic dialdehyde is increased in patients with repeated brain concussion and decreased in severe brain contusion. The level of medium-weight molecules is increased in all patients with craniocerebral injuries. The activities of these enzymes are virtually unchanged in the patients with lethal outcomes.
Assuntos
Traumatismos Craniocerebrais/sangue , Malondialdeído/sangue , Oxirredutases/sangue , Adolescente , Adulto , Concussão Encefálica/sangue , Traumatismos Craniocerebrais/mortalidade , Interpretação Estatística de Dados , Glutamato Desidrogenase/sangue , Humanos , Pessoa de Meia-Idade , Prognóstico , Recidiva , Índice de Gravidade de Doença , Succinato Desidrogenase/sangue , Fatores de TempoRESUMO
It is shown that 24 hours after closed craniocerebral trauma plasma serotonin significantly rises in patients with moderate brain concussion and contusion. In repeated brain concussion and severe contusion these changes were absent. This may be due to biochemical maladaptation. Serotonin levels in patients with brain contusion lowered significantly 15 and 22 days after the trauma.
