Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Nat Prod Res ; 35(21): 3745-3751, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32162538

RESUMO

Two new neolignan sesquiterpenoids, chevalierinol A (1) and chevalierinol B (2), were isolated from the ethyl acetate extract of Magnolia chevalieri leaves, together with twelve known compounds (3-14). Their structures were elucidated by analysis of spectroscopic data including 1D, 2D and mass spectra and compared with the reported data. Compounds 1, 3, 4, 6, 7, 10 were evaluated for their inhibitory effect against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophage cells.


Assuntos
Lignanas , Magnolia , Sesquiterpenos , Animais , Lignanas/farmacologia , Lipopolissacarídeos , Camundongos , Estrutura Molecular , Óxido Nítrico , Células RAW 264.7 , Sesquiterpenos/farmacologia
2.
RSC Adv ; 11(57): 35765-35782, 2021 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-35492788

RESUMO

Dipterocarpus alatus-derived products are expected to exhibit anti-diabetes properties. Natural dipterocarpol (1) was isolated from Dipterocarpus alatus collected in Quang Nam province, Vietnam; afterwards, 20 derivatives including 13 oxime esters (2 and 3a-3m) and 7 lactones (4, 5, 6a-6e) were semi-synthesised. Their inhibitory effects towards diabetes-related proteins were investigated experimentally (α-glucosidase) and computationally (3W37, 3AJ7, and PTP1B). Except for compound 2, the other 19 compounds (3a-3m, 4, 5, and 6a-6d) are reported for the first time, which were modified at positions C-3, C-24 and C-25 of the dipterocarpol via imidation, esterification, oxidative cleavage and lactonisation reactions. A framework based on docking-QSARIS combination was proposed to predict the inhibitory behaviour of the ligand-protein complexes. Enzyme assays revealed the most effective α-glucosidase inhibitors, which follow the order 5 (IC50 of 2.73 ± 0.05 µM) > 6c (IC50 of 4.62 ± 0.12 µM) > 6e (IC50 of 7.31 ± 0.11 µM), and the computation-based analysis confirmed this, i.e., 5 (mass: 416.2 amu; polarisability: 52.4 Å3; DS: -14.9 kcal mol-1) > 6c (mass: 490.1 amu; polarisability: 48.8 Å3; DS: -13.7 kcal mol-1) > 6e (mass: 549.2 amu; polarisability: 51.6 Å3; DS: -15.2 kcal mol-1). Further theoretical justifications predicted 5 and 6c as versatile anti-diabetic inhibitors. The experimental results encourage next stages for the development of anti-diabetic drugs and the computational strategy invites more relevant work for validation.

3.
Nat Prod Res ; 27(8): 771-4, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22712581

RESUMO

Peristrophe bivalvis (L.) Merr. (Acanthaceae) is a wild growing and cultivated plant used for dyeing of foods by the ethnic minorities of Vietnam. The major component of the colour aqueous extract (CAE) of its leaves was identified as peristrophine by spectral analysis, especially the 2D NMR spectra (HSQC, HMBC and NOESY). Considering the widespread utilisation of the decoction of this plant for food dyeing, we evaluated the acute oral toxicity of the CAE. Based on the results in an acute toxicity study in mice, the LD50 value of the CAE was determined as 9100 ± 290 mg kg(-1) body weight. Additionally, in vitro cytotoxic assay showed an inhibition of peristrophine against Hepatocellular carcinoma (HepG2, IC503.90 µg mL(-1)). CAE and peristrophine (1) have also been tested for their ability to affect the cell number of the OCI acute myeloid leukaemia cell line. CAE and peristrophine significantly decreased the OCI cell number at different concentrations and times of treatment.


Assuntos
Acanthaceae/química , Antineoplásicos Fitogênicos/isolamento & purificação , Corantes/isolamento & purificação , Oxazinas/isolamento & purificação , Acanthaceae/toxicidade , Animais , Antineoplásicos Fitogênicos/química , Corantes/química , Ensaios de Seleção de Medicamentos Antitumorais , Células Hep G2 , Humanos , Espectroscopia de Ressonância Magnética , Camundongos , Estrutura Molecular , Oxazinas/química , Folhas de Planta/química , Espectrometria de Massas por Ionização por Electrospray
4.
Nat Prod Commun ; 7(2): 179-80, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22474948

RESUMO

A study of the chemical constituents of a methanolic extract of the roots of Livistona halongensis (Arecaceae) led to the isolation of two new flavanes, 2S,3S-3,5,7,3'-tetrahydroxy-5'-methoxyflavane (1) and 3,7,3'-trihydroxy-5'-methoxyflavane 5-O-beta-glucopyranoside (2), together with trans-3,5,3',5'-tetrahydroxy-4-methoxystilbene, saccharose and beta-sitosterol-3-O-beta-glucopyranoside. The structures of these compounds were elucidated on the basis of spectroscopic data.


Assuntos
Arecaceae/química , Flavonoides/química , Glucosídeos/química , Estrutura Molecular , Raízes de Plantas/química
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...