Left ventricular systolic dysfunction is an independent predictor of homocysteine in angiographically documented patients with or without coronary artery lesions.

BACKGROUND: Elevated plasma homocysteine is a risk factor for coronary artery disease (CAD) and thromboembolic disorders that seems also to be associated with chronic heart failure. OBJECTIVE: To evaluate the association between homocysteine and left ventricular dysfunction and to assess whether it is independent of CAD. PATIENTS AND METHODS: A prospective study evaluated this relationship in 709 patients referred for diagnostic coronary angiography, including 515 CAD and 194 patients without evidence of coronary artery lesions. RESULTS: The homocysteine level was significantly higher in the 187 patients with a left ventricular ejection fraction (LVEF) dysfunction < 40% (P < 0.0001) than in those without ventricular dysfunction. LVEF, NYHA functional class II or III and CAD, stable angina and hypertension were clinical characteristics that influenced total homocysteine level in univariate analysis. Homocysteine was significantly associated with LVEF and N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) in univariate regression (r = -0.267, 95% CI -0.33 to -0.19, P < 0.0001, and r = 0.381, 95% CI 0.28-0.47, P < 0.0001, respectively) and in multiple regression (P = 0.0022 and P = 0.0001, respectively). Other determinants were creatinine and vitamin B(12), but not folate. LVEF was a predictor of homocysteine > 15 micromol L(-1) in the whole population (P for trend < or = 0.0001) and in patients without documented CAD (P for trend = 0.0058). CONCLUSION: Our results showed an association of homocysteine with left ventricular systolic dysfunction and NT-pro-BNP that existed independently of documented CAD. Whether this association reflects a causative factor or a consequence of CHF and influences the prognosis of the disease remains an open question.

[Significance of isuprel infusion in unexplained syncope after myocardial infarction]. / Intérêt de la perfusion d'Isuprel dans le bilan des syncopes inexpliquées après infarctus du myocarde.

UNLABELLED: The prognosis for patients with complications and syncope following myocardial infarction depends on the left ventricular ejection fraction (LVEF) and the mechanism of the syncope. The aim of this study was to evaluate the results of an electrophysiological study (EPS) following isoproterenol infusion in patients with a negative EPS under basal conditions. The population included 60 patients, aged 60 +/- 12 years, 5 of whom had syncope on effort or with stress. The EPS included measurement of AV conduction, with programmed atrial and ventricular stimulation. It was repeated following infusion of 2 to 4 microg/kg of isoproterenol. RESULTS: An arrhythmia was identified as preceding the syncope in 27 patients (45%): ventricular tachycardia (VT) n = 16, supraventricular tachycardia (n = 5), 2nd or 3rd degree AV block (n = 3), vaso-vagal reaction (n = 3): 3 subjects developed coronary ischaemia. The subjects with VT on Isuprel differed from those without VT, with a lower LVEF (34 +/- 8 vs 45 +/- 14%) (p < 0.05), a higher incidence of effort related syncope (4 vs 1) and a higher risk of cardiac death (6/16 vs 2/44) (p < 0.01). In conclusion, we recommend repeating the electrophysiogical test under Isuprel in patients with complications after MI and a negative EPS in the basal state whether or not they have exercise related syncope, which will reveal an arrhythmia in 45% of cases. Subjects with inducible VT are at high risk of cardiac death.

[Prevalence of supraventricular tachycardia and tachyarrhythmias in resuscitated cardiac arrest]. / Incidence des tachycardies et tachyarythmies supraventriculaires dans les morts subites récupérées.

Supraventricular arrhythmias are considered to be benign when the ventricular rate is slowed and treated by anticoagulants. The aim of this study was to determine the possible influence of these arrhythmias in resuscitated cardiac arrest. Between 1980 and 2002, 151 patients were admitted after a cardiac arrest. Supraventricular arrhythrmias were identified as a possible cause of the cardiac arrest in 21 patients. They underwent echocardiography, exercise stress test, Holter ECG monitoring , coronary angiography and electrophysiological investigation. After these investigations, three patients had a malignant form of the Wolff-Parkinson-White syndrome, two were asymptomatic and, in the third patient, ventricular fibrillation was induced by treatment with diltiazem. In 8 patients, a rapid supraventricular arrhythmia was considered to be the cause of cardiac arrest by cardiogenic shock; 2 patients had hypertrophic cardiomyopathy, 5 had severe dilated cardiomyopathy which regressed in one patient. In ten patients, cardiac arrest due to ventricular tachycardia or fibrillation was provoked by a rapid (> 220 beats/min) supraventricular arrhythmia; two patients had no apparent underlying cardiac pathology. In the others, myocardial ischaemia or acute cardiac failure were considered to be the cause of the cardiac arrest. The authors conclude that rapid supraventricular arrhythmias may cause cardiac arrest either by cardiogenic shock or degenerescence to ventricular tachycardia or fibrillation. Usually, this event occurs in patients with severe cardiac disease but it may occur in subjects without cardiac disease or by an arrhythmia-induced cardiomyopathy.

[Evaluation of ventricular asynchronism by Doppler tissue imaging in patients with idiopathic dilated cardiomyopathy]. / Evaluation de l'asynchronisme ventriculaire par échocardiographie Doppler tissulaire chez les patients atteints d'une cardiomyopathie dilatée idiopathique à QRS fins.

OBJECTIVES: To study ventricular asynchronism with tissue Doppler imaging in patients with primitive dilated cardiomyopathy and narrow QRS. PATIENTS AND METHODS: We compared a group of patients with DCM and QRS < 120 ms (gr 1, n=25, 52+/-14 yrs, LVEF: 25+/-9%) with a group of normal patients (gr 2, n=16, 36+/-20 yrs). We measured the delays between the beginning of QRS and the beginnings of aortic (QA), mitral (QM), tricuspid (QT) and pulmonary (QP) flows, and of systolic (QSm) and protodiastolic (QEm) wall motion waves recorded with TDI in the basal portion of interventricular septum (IVS) and LV and RV free walls. We then calculated the differences QA-QP, QM-QT, the interparietal differences for QSm and QEm, and the maximal interparietal systolic (QSm max) and diastolic (QEm max) delays. RESULTS: QA, QP, QM and QT were significantly lengthened in group 1 patients but there were no difference between both groups for QA-QP and QM-QT. There was a trend toward a lengthening of QSm and QEm in group 1 patients. Interparietal differences of QSm and QEm were similar in both groups; however, QSm max and QEm max were significantly longer in group 1 patients than in group 2. CONCLUSION: Doppler study of patients with DCM and narrow QRS shows a lengthening of all electromechanical delays and suggests some degree of ventricular asynchronism by showing a significant increase in maximal interparietal systolic and diastolic delays.

Wide QRS complex tachycardia. Rapid method of prognostic evaluation.

UNLABELLED: A wide QRS complex tachycardia suggests a ventricular tachycardia (VT); but supraventricular tachycardia (SVT) is also possible. Some authors reported on the electrocardiographic signs for the differential diagnosis of VT and SVT with aberrancy. Frequently these signs are debatable and the diagnosis is uncertain. The purpose of the study was to evaluate the interest of a non-invasive study by transesophageal route for the evaluation of the nature of a wide QRS complex tachycardia in which a reliable ECG algorithm does not permit to distinguish VT from SVT with aberrancy. METHODS: Esophageal electrophysiologic study (EPS) was performed in 53 patients, aged from 16 to 85 years without bundle branch block (BBB) in sinus rhythm, but with wide-QRS tachycardia. The protocol consisted of atrial pacing at progressively higher rates and then programmed stimulation with one and two extrastimuli in control state and after isoproterenol infusion. Intracardiac EPS was performed in 49 of them. RESULTS: (1) Study was negative in nine patients; intracardiac EPS remained negative in four of them, induced a VT in five; (2) clinical tachycardia was induced in 44 patients: (a) in 29 of them, atrial pacing induced a BBB similar to aberrancy noted in tachycardia and the diagnosis of SVT with aberrancy was made; (b) in 15 patients, QRS complex remained narrow during atrial pacing; the diagnosis of VT was made in presence of AV dissociation and confirmed by intracardiac study. VT was induced by atrial or ventricular stimulation or was spontaneous during isoproterenol infusion. VT mechanism were bundle branch reentry [Am. J. Cardiol. 65 (1990) 322], verapamilsensitive VT [Am. J. Cardiol. 65 (1990) 322], catecholamine-sensitive VT [J. Cardiovasc. Electrophysiol. 7 (1996) 2]. Two patients had tachycardias of both natures either supraventricular or ventricular. CONCLUSION: Esophageal EPS was a safe, rapid and economic means to evaluate the mechanism of wide QRS tachycardia in 84% of patients; atrial pacing at progressively higher rates is very simple to reproduce the aberrancy of similar morphology in those patients who had wide-QRS tachycardia related to a SVT with aberrancy. If atrial pacing did not exactly reproduce the aberrancy in tachycardia, a VT should be suspected.

[Does syncope change the results of programmed ventricular stimulation in patients with previous myocardial infarction?]. / La syncope change-t-elle les résultats de la stimulation ventriculaire programmée chez les patients ayant un antécédent d'infarctus du myocarde?

UNLABELLED: The induction of a ventricular tachycardia (VT) after myocardial infarction (MI) is associated with a high risk of VT and sudden death (SD) in asymptomatic patients; the purpose of the study was to know if syncope modifies the results of programmed ventricular stimulation (PVS) and the clinical consequences. METHODS: PVS using two and three extra stimuli delivered in two sites of right ventricle was performed in 1057 patients without spontaneous VT or resuscitated SD at least 1 month after an acute MI; 836 patients (group I) were asymptomatic and were studied for a low ejection fraction or nonsustained VT on Holter monitoring or late potentials; 228 patients (group II) were studied for unexplained syncope. The patients were followed up to 5 years of heart transplantation. RESULTS: Sustained monomorphic VT (< 280 b/min) was induced in 238 group I patients (28%) and 62 group II patients (29%); ventricular flutter (VT > 270 b/min) or ventricular fibrillation (VF) was induced in 245 group I patients (29%) and 42 group II patients (18%) (P < 0.05); PVS was negative in 353 group I patients (42%) and 124 (55%) group II patients (NS). The patients differ by their prognosis; cardiac mortality was 13% in group I patients and 34% in group II patients with inducible VT < 280 b/min (P < 0.01), 4% in group I patients and 13% in group II patients with inducible VF (P < 0.05), 5% in group I patients and 7% in group II patients with negative study (NS). In conclusion, syncope did not change the results of programmed ventricular stimulation after myocardial infarction. However, syncope increased significantly cardiac mortality of patients with inducible ventricular tachycardia, flutter or fibrillation.

[Causes and prognosis of syncope in patients with primary dilated cardiomyopathy]. / Causes et pronostic des syncopes chez les patients avec une cardiomyopathie dilatée primitive.

The causes of adverse prognosis of patients with primary dilated cardiomyopathy remain controversial. Classically, it is thought that syncope is associated with an increased risk of mortality. The aim of this study was to try and identify the causes and prognostic significance of syncope in patients with primary dilated cardiomyopathy. Sixty-five patients aged 31 to 80 with primary dilated cardiomyopathy were admitted for investigation of syncope. The average ejection fraction was 27 +/- 10%. Invasive and non-invasive investigations including complete electrophysiological investigations, were performed. Sustained monomorphic ventricular tachycardia was induced in 14 patients (21.5%), ventricular flutter or fibrillation was induced in 9 patients (14%), a supraventricular arrhythmia in 17 patients (26%), and a conduction defect alone or associated with another arrhythmia in 7 patients (11%). A pathological result of tilt testing was observed in 5 patients (8%). No cause of syncope could be demonstrated in 15 patients (23%). During follow-up (4 +/- 2 years) there was a mortality of 15% which was only correlated with the reduction in left ventricular ejection fraction. The authors conclude that there are many causes of syncope in primary dilated cardiomyopathy: ventricular arrhythmias represent only 35% of cases and do not impact on the prognosis; above all, left ventricular ejection fraction is the most important prognostic factor.

Transitory or permanent regular wide QRS complex tachycardia induced by atrial stimulation in patients without apparent heart disease. Significance.

OBJECTIVES: The purpose of the study was to evaluate the frequency of transitory or permanent bundle branch block (BBB) associated with a paroxysmal tachycardia induced by atrial stimulation in patients without heart disease and its significance. METHODS: Esophageal atrial stimulation was performed in 447 patients suspected to have supraventricular tachycardias (SVT). Sustained regular tachycardia was induced in all of them but three, either in control state (75%) or after administering isoproterenol. In 346 patients, only narrow complex SVTs were induced (77%); in 259 of them, the reentry occurred in the AV node and in remaining patients within a concealed accessory pathway. In 62 patients, a transitory functional BBB was recorded at the onset of the tachycardia (14%). In 33 of them, the reentry occurred in the AV node and in the remaining 29 patients within a concealed accessory pathway. In 36 patients (8%), a permanently wide QRS complex tachycardia was induced. Three patients had also inducible narrow complex SVT. Atrial pacing induced a BBB similar to the aberrancy in tachycardia in 22 patients: the reentry occurred in the AV node in 17 patients, within a concealed accessory pathway in three patients and in a Mahaim bundle in two patients. In other patients, QRS complex remained normal during atrial pacing: all 14 patients had a ventricular tachycardia (VT), either a verapamil-sensitive VT (n = 7) or catecholamine-sensitive VT (n = 4) or bundle branch reentry (n = 3). Followed from 2 to 12 years, the prognosis of these patients was excellent. CONCLUSION: Transitory BBB at the onset of an SVT is noted in 14% of the population, is more frequent in patients with accessory pathway reentrant tachycardia, but is helpful for this diagnosis in only 12% of cases. A regular tachycardia with permanent left or right bundle branch morphology induced by atrial stimulation in a patient without heart disease and without BBB during atrial pacing is due to a VT even if this patient has also narrow complex tachycardias. This mechanism does not affect the excellent prognosis of this population.

[Syncope in patients with normal EKG and without cardiac disease: value of ambulatory esophageal electrophysiology in determining etiology]. / Syncopes chez des patients avec ECG normal sans cardiopathie: intérêt étiologique d'une étude électrophysiologique par voie oesophagienne en ambulatoire.

The aim of this study was to determine whether ambulatory oesophageal electrophysiological recordings are valuable in identifying the cause of syncope in patients with a normal ECG and without cardiac disease. One hundred and forty-five patients aged 16 to 88 years of age, without cardiac disease, and with a normal ECG without a documented arrhythmia, were examined for unexplained syncope: 55 patients complained of palpitations at the time of syncope. The electrophysiological study was carried out in the clinic with oesophageal recordings using a classical protocol: Wenckebach point and sinus node recovery time were determined; programmed atrial stimulation was used with delivery of 1 and 2 extra-stimuli on the basal rhythm and with 20/30 micrograms infusion of isoprenaline; blood pressure was monitored. The study was negative in 41 patients (28%). Sinus node dysfunction was observed in 9 patients (6%). A vaso-vagal reaction reproducing the symptoms was induced by isoprenaline in 21 patients (14.5%); a conduction defect was revealed in 2 cases (1%). Atrial fibrillation or tachycardia > 1 minute was induced in 22 patients (15%). Paroxysmal junctional tachycardia was induced in 50 patients (35%). Patients with a negative study were younger than those with sinus node dysfunction or atrial fibrillation (44 +/- 21, 71 +/- 9 and 63 +/- 14 years respectively). Treatment was guided by these results: cardiac pacing, antiarrhythmic therapy or radiofrequency ablation of the reentrant pathway were indicated and suppressed syncope in all but two patients. The authors conclude that electrophysiological studies in the out-patient clinic with oesophageal recordings is a safe, rapid and economic method of detecting arrhythmias (sinus node dysfunction or supraventricular tachycardia) in 60% of patients with syncope, especially if they have symptoms of palpitations.

[Doppler tissue imaging of the myocardium and right ventricle]. / Doppler tissulaire myocardique et ventricule droit.

Doppler tissue imaging is a technique of analysis of myocardial wall motion. It may easily be used for the right ventricular walls, especially in the apical 4-chamber view, from which the velocities of the RV free wall can be measured from the tricuspid annulus to the apex. The regional velocities of the right ventricle in its long axis and the excursion of the tricuspid annulus are higher than those of the left ventricle but the velocities of circumferential fibre shortening are lower. Moreover, the time interval between the end of the Sm wave and the onset of the Em wave (equivalent to the isovolumic relaxation time) is almost virtual in the right ventricle. The parameters of deformation (strain rate, strain) are also higher in the right than in the left ventricle and are variably distributed. Several studies have examined the clinical value of Doppler tissue imaging of the right ventricle. In cardiac failure, a significant correlation between the systolic velocity of the tricuspid annulus displacement and right ventricular ejection fraction has been reported. The ratio of tricuspid E wave velocity to the tricuspid annulus B wave allow assessment of right ventricular filling pressures. The measurement of tricuspid annulus velocities could be diagnostic of right ventricular extension of an inferior wall infarct. The recording of a "rebound" positive wave just after the E wave in the RV and LV free walls (and in the interventricular septum) is a diagnostic sign of constrictive pericarditis. Doppler tissue imaging is therefore a promising technique for evaluating right ventricular function.

[Treatment with lepirudin in heparin-induced thrombocytopenia. A case report]. / Traitement par lépirudine au cours d'une thrombopénie à l'héparine. A propos d'un cas.

We report the case of a 71 old woman presenting a bilateral massive pulmonary embolism with intraventricular right thrombus complicating heparin induced thrombocytopenia (HIT) persistent after one month of conventional anticoagulant processing. We underline the effectiveness of lepirudin (Refludan) in the curative processing of pulmonary embolism allowing here to avoid a complex surgical thromboembolectomy. We evoke the place of this molecule in the curative therapeutic strategy of HIT with thrombotic phenomena.

[Transesophageal electrophysiology study, a simple method of investigation of unexplained illness in elderly patients]. / Etude électrophysiologique par voie transoesophagienne, moyen simple d'investigation de malaises inexpliqués, chez des sujets âgés.

Cardiac arrhythmias are common causes of syncope and malaise in elderly patients, but they are sometimes difficult to demonstrate without invasive procedures. The aim of this report was to demonstrate the value of transoesophageal electrophysiological investigation in cases of negative classical non-invasive studies. The authors report 18 cases of patients, aged 70 to 88, mainly in poor general condition, who were admitted for the investigation of malaise or syncope. The ECG was normal or subnormal and Holter monitoring non-contributive to the diagnosis. Transoesophageal electrophysiological study enabled initiation of an arrhythmia, bradycardia or tachycardia, which reproduced the symptoms of spontaneous malaise. In 10 cases, paroxysmal junctional tachycardia was demonstrated, by nodal reentry in 8 cases, and in a latent Kent bundle in 2 cases. The malaise was caused by tachyarrhythmia in 3 patients and by a vagal reaction or sinus arrest after the tachycardia in the other patients. In 6 other patients, atrial fibrillation reproduced the malaise either due to the rapid rhythm, or to bradycardia after the arrhythmia in 3 cases. In another 2 patients, conduction defects were demonstrated by atrial stimulation (alternating bundle branch block in one patient, complete atrioventricular block at the end of atrial stimulation in another patient). The authors conclude that transoesophageal electrophysiological study is a simple technique which allows diagnosis of unexplained malaise in elderly patients when non-invasive methods are unable to demonstrate the causal arrhythmia. Supraventricular arrhythmias seem to be a common and probably underestimated cause of malaise or syncope in elderly patients.