1.
Bioorg Med Chem Lett
; 24(1): 378-81, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24269163
RESUMO
The design, synthesis, and SAR of cyclic diamines as novel γ secretase modulators (GSMs) are presented in this Letter. Starting from information in the literature and in-house cyclic diamines library, we have found a 3(S)-aminopiperidine as a potent structure for lowering Aß42 production both in vitro and in vivo.