Richtmyer-Meshkov instability: theory of linear and nonlinear evolution.

A theoretical framework to study linear and nonlinear Richtmyer-Meshkov instability (RMI) is presented. This instability typically develops when an incident shock crosses a corrugated material interface separating two fluids with different thermodynamic properties. Because the contact surface is rippled, the transmitted and reflected wavefronts are also corrugated, and some circulation is generated at the material boundary. The velocity circulation is progressively modified by the sound wave field radiated by the wavefronts, and ripple growth at the contact surface reaches a constant asymptotic normal velocity when the shocks/rarefactions are distant enough. The instability growth is driven by two effects: an initial deposition of velocity circulation at the material interface by the corrugated shock fronts and its subsequent variation in time due to the sonic field of pressure perturbations radiated by the deformed shocks. First, an exact analytical model to determine the asymptotic linear growth rate is presented and its dependence on the governing parameters is briefly discussed. Instabilities referred to as RM-like, driven by localized non-uniform vorticity, also exist; they are either initially deposited or supplied by external sources. Ablative RMI and its stabilization mechanisms are discussed as an example. When the ripple amplitude increases and becomes comparable to the perturbation wavelength, the instability enters the nonlinear phase and the perturbation velocity starts to decrease. An analytical model to describe this second stage of instability evolution is presented within the limit of incompressible and irrotational fluids, based on the dynamics of the contact surface circulation. RMI in solids and liquids is also presented via molecular dynamics simulations for planar and cylindrical geometries, where we show the generation of vorticity even in viscid materials.

Effect of position of electrodes relative to the innervation zone onsurface EMG.

We investigated the effect of the position of electrodes relative to the innervation zone (IZ) of the biceps brachii muscle during isometric elbow flexion using eight-channel surface array electrodes. We estimated the location of the IZ near the centre of the muscle in 20 male subjects. The pulse peaks from electromyogram (EMG) waveforms were detected for each channel and averaged, the triphasic pulse was determined, and the peak values of the first and third phases were compared. The results showed significantly greater pulse values for the first phase when the electrode placement was proximal to the estimated IZ, and for the third phase when the electrode placement was distal to the estimated IZ. Using this method, the positional relationship between electrodes and IZ can be determined using a surface EMG waveform recorded with a pair of bipolar electrodes. This method may be clinically useful in confirming the reliability of a recorded surface EMG.

A case of small cell carcinoma in the buccal region.

Small cell carcinoma (SCC) in the head and neck region is an extremely rare high-grade malignant tumor. The authors report a case of an SCC occurring in the left buccal region. An 85-year-old man exhibited left cheek swelling that rapidly increased in size. Histopathological examination revealed invasive growth of an SCC into the musculo-adipose tissue. Immunohistochemically, the tumor cells were positive for cytokeratin (AE1/AE3), neuron-specific enolase (NSE) and CD56, but negative for cytokeratin 20. The patient received chemotherapy and radiotherapy, which resulted in marked regression of the tumor. Surgical resection was performed. The serum levels of NSE and pro-gastrin-releasing peptide (pro-GRP) increased and multiple metastases of the tumor occurred 1 month after surgery. SCCs tend to exhibit aggressive invasion and metastasis so chemotherapy for the whole body is recommended to prevent dissemination of the tumor cells. Serum levels of NSE and pro-GRP are considered to be useful tumor markers for understanding the status of the tumor and the clinical symptoms.

A quantitative radiological assessment of outcomes of autogenous bone graft combined with platelet-rich plasma in the alveolar cleft.

This longitudinal study evaluated the outcomes of secondary autogenous bone graft combined with platelet-rich plasma (PRP) in the alveolar cleft. Thirty-five alveolar clefts in 30 patients with grafted autogenous bone and PRP (PRP group), and 36 clefts in 30 patients with grafted autogenous bone alone (non-PRP group) were enrolled. PRP was extracted from autogenous blood using a plasma centrifuge system (SmartPReP SMP-1000). The density and resorption of grafted bone were evaluated at 1 week, and 1, 3, 6 and 12 months postoperatively. Bone density was quantitatively assessed as an aluminum-equivalence (Al-Eq) value. Moreover, relationships between bone resorption rate and prognostic factors were discussed. Al-Eq values decreased significantly until 3 months, and then increased up to 12 months in both groups. The Al-Eq rate in the PRP group was significantly smaller than that in the non-PRP group at 3 months. No significant differences were observed in the bone resorption rate between the groups. Regarding prognostic factors, continuous mechanical stress affected bone resorption with or without PRP. The authors suggest that PRP may enhance bone remodeling in the early phase, however, PRP seems to be insufficient as a countermeasure against bone resorption following secondary bone graft in the long term.

Contrasting alteration patterns of different cartilage plates in knee articular cartilage after spinal cord injury in rats.

STUDY DESIGN: Experimental, controlled trial, animal study. OBJECTIVE: To assess morphologic changes in different cartilage plates after spinal cord injury and identify the localization of these alterations. SETTING: Saitama, Japan. METHODS: A total of 16 Wistar rats were used. Eight rats underwent a spinal cord injury and eight rats had no intervention as control. The cartilage alterations of the knee joint were evaluated with radiography and histomorphometric analysis. To quantify cartilage alterations, we selected the histologic characteristics: thickness of the articular cartilage, number of chondrocytes, matrix staining to toluidine blue as a reflection of proteoglycan content and surface irregularity. RESULTS: No differences in knee joints were found between the groups by radiography. In the medial knee joint, cartilage thickness of spinal-cord-injured knees increased at the anterior femoral region and decreased at the tibial and posterior femoral regions; however, in the lateral knee, that of spinal cord injuries did not change compared with control knees. Spinal cord injuries decreased the number of chondrocytes, especially at the anterior femoral regions. Matrix staining increased partially at the tibial regions. Surface irregularity of spinal-cord-injured knees was comparable to that of control knees in all cartilage plates. CONCLUSION: The present findings exhibit characteristics of the cartilage after spinal cord injury. These alterations were different in nature between the medial and lateral regions. Future studies should assess separately different cartilage plates, to overestimate these severities when the changes at the medial knee were examined and to underestimate when the changes at the lateral knee were examined.

Intradural microsurgery and extradural gamma knife surgery for hypoglossal schwannoma: case report and review of the literature.

There have been only 26 cases of hypoglossal schwannomas reported to originate intradurally and extend extradurally into the hypoglossal canal. This 31-year-old mother of two children presented with a 5-day history of progressive headache, nausea, vomiting and vertigo. Her neurological exam was significant for nystagmus and left tongue deviation with marked atrophy. An initial head CT revealed extensive left hypoglossal canal erosion with 4th ventricle compression. T1-weighted MR images with contrast revealed a 4x3 cm left cerebellopontine angle non-homogeneously enhancing mass with an intracranial cystic component and prominent extension into the eroded hypoglossal canal. A left lateral suboccipital craniotomy was performed for subtotal microsurgical resection of the intradural posterior fossa mass. A schwannoma was diagnosed after resection and gamma knife surgery (GKS) was performed three months later for the extradural residual tumor without further deficits. This is a rare report of a hypoglossal schwannoma in a young patient who was treated with a multimodality approach in order to minimize risks. A review of the literature and discussion of the respective benefits of microsurgery versus GKS and long-term follow-up issues are presented.

[Cavitating pleomorphic carcinoma of the lung; report of a case].

We report a case of a previously healthy 76-year-old male with cavitating pleomorphic carcinoma of the lung. He was admitted because of an abnormal lung shadow on chest X-ray. Computed tomography (CT) showed a well-demarcated nodular shadow within thin-walled cavity in the right upper lobe. Because the lesion was revealed as adenocarcinoma by transbronchial lung biopsy, right upper lobectomy was performed. By histopathologic examination of the resected specimen, the nodule contained a component of spindle cell features and the cavity wall was composed of adenocarcinoma. The final diagnosis was pleomorphic carcinoma. Postoperative course has been uneventful for 12 months after surgery.

Multiscale character of the nonlinear coherent dynamics in the Rayleigh-Taylor instability.

We report nonlinear solutions for a system of conservation laws describing the dynamics of the large-scale coherent structure of bubbles and spikes in the Rayleigh-Taylor instability (RTI) for fluids with a finite density ratio. Three-dimensional flows are considered with general type of symmetry in the plane normal to the direction of gravity. The nonlocal properties of the interface evolution are accounted for on the basis of group theory. It is shown that isotropic coherent structures are stable. For anisotropic structures, secondary instabilities develop with the growth rate determined by the density ratio. For stable structures, the curvature and velocity of the nonlinear bubble have nontrivial dependencies on the density ratio, yet their mutual dependence on one another has an invariant form independent of the density ratio. The process of bubble merge is not considered. Based on the obtained results we argue that the large-scale coherent dynamics in RTI has a multiscale character and is governed by two length scales: the period of the coherent structure and the bubble (spike) position.

[Usefulness of the eradication of Helicobacter pylori for the patient with idiopathic thrombocytopenic purpura and lung cancer: report of a case].

A 61-year-old female was admitted because of an abnormal lung shadow on chest X-ray. She had suffered from idiopathic thrombocytopenic purpura (ITP) for more than 7 years. Computed tomography (CT) revealed that an irregular shadow, about 2 cm in diameter, was located in the upper lobe of the right lung. After intravenous immunogrobulin injections for 5 days, a hematology test indicated increased platelet counts and we performed thoracoscopic surgery successfully without blood transfusions. However, 4 months after surgery, a hematology test indicated decreased platelet counts again. Thirteen months after the operation, gastrointestinal fiberscopic examination showed Helicobacter pylori infection. After the urea breath test, eradication therapy let to a recovery in platelet counts.

Normal velocity freeze-out of the Richtmyer-Meshkov instability when a shock is reflected.

It is known that for some values of the initial parameters that define the Richtmyer-Meshkov instability, the normal velocity at the contact surface vanishes asymptotically in time. This phenomenon, called freeze-out, is studied here with an exact analytic model. The instability freeze-out, already considered by previous authors [K.O. Mikaelian, Phys. Fluids 6, 356 (1994), Y. Yang, Q. Zhang, and D.H. Sharp, Phys. Fluids 6, 1856 (1994), and A.L. Velikovich, Phys. Fluids 8, 1666 (1996)], is the result of a subtle interaction between the unstable surface and the corrugated shock fronts. In particular, it is seen that the transmitted shock at the contact surface plays a key role in determining the asymptotic behavior of the normal velocity at the contact surface. By properly tuning the fluids compressibilities, the density jump, and the incident shock Mach number, the value of the initial circulation deposited by the reflected and transmitted shocks at the material interface can be adjusted in such a way that the normal growth at the contact surface will vanish for large times. The conditions for this to happen are calculated exactly, by expressing the initial density ratio as a function of the other parameters of the problem: fluids compressibilities and incident shock Mach number. This is done by means of a linear theory model developed in a previous work [J.G. Wouchuk, Phys. Rev. E. 63, 056303 (2001)]. A general and qualitative criterion to decide the conditions for freezing-out is derived, and the evolution of different cases (freeze-out and non-freeze-out) are studied with some detail. A comparison with previous works is also presented.

Ion generation in a low-density plastic foam by interaction with intense femtosecond laser pulses.

Energetic proton generation in low-density plastic (C5H10) foam by intense femtosecond laser pulse irradiation has been studied experimentally and numerically. Plastic foam was successfully produced by a sol-gel method, achieving an average density of 10 mg/cm(3). The foam target was irradiated by 100 fs pulses of a laser intensity 1 x 10(18) W/cm(2). A plateau structure extending up to 200 keV was observed in the energy distribution of protons generated from the foam target, with the plateau shape well explained by Coulomb explosion of lamella in the foam. The laser-foam interaction and ion generation were studied qualitatively by two-dimensional particle-in-cell simulations, which indicated that energetic protons are mainly generated by the Coulomb explosion. From the results, the efficiency of energetic ion generation in a low-density foam target by Coulomb explosion is expected to be higher than in a gas-cluster target.

Proposed double-layer target for the generation of high-quality laser-accelerated ion beams.

In order to achieve a high-quality, i.e., monoenergetic, intense ion beam, we propose the use of a double-layer target. The first layer, at the target front, consists of high-Z atoms, while the second (rear) layer is a thin coating of low-Z atoms. The generation of high-quality proton beams from the double-layer target, irradiated by an ultraintense laser pulse, is demonstrated with three-dimensional particle-in-cell simulations.

Polarization effects and anisotropy in three-dimensional relativistic self-focusing.

The relativistic self-focusing of high-intensity laser pulses in underdense plasmas is investigated with three-dimensional particle in cell simulations. The different behavior of a linearly polarized pulse in the two transverse directions is interpreted as a combination of two two-dimensional responses with different polarizations. In the polarization plane a high density sheet is formed, which separates the two regions of oppositely directed quasistatic magnetic field.

Three-dimensional particle-in-cell simulations of energetic electron generation and transport with relativistic laser pulses in overdense plasmas.

The interaction of relativistic laser light with overdense plasmas is studied by three-dimensional particle-in-cell simulations. Generation of layered current sheets and quasistatic magnetic fields is observed near the target surface owing to anisotropic laser filamentation and Weibel instabilities. Later these current sheets tear into filaments that partially merge with each other to form isolated magnetic channels penetrating into the dense plasmas. It is found that fast electron energy flow is not only inside the magnetic channels but also it is widely distributed outside the channels. This is possible because of electron anomalous diffusion across self-generated magnetic fields. Consequently, the total hot electron current exceeds a few hundred kiloamperes and is much larger than the Alfvén current. Hence a considerable amount of energy flows towards the plasma core. Significant heating of the bulk plasma electrons is also observed.

Anisotropic filamentation instability of intense laser beams in plasmas near the critical density.

The relativistic filamentation instability (RFI) of linearly polarized intense laser beams in plasmas near the critical density is investigated. It is found that the RFI is anisotropic to transverse perturbations in this case; a homogeneous laser beam evolves to a stratified structure parallel to the laser polarization direction, as demonstrated recently with three-dimensional particle-in-cell simulations by Nishihara et al. [Proc. SPIE 3886, 90 (2000)]. A weakly relativistic theory is developed for plasmas near the critical density. It shows that the anisotropy of the RFI results from a suppression of the instability in the laser polarization direction due to the electrostatic response. The anisotropic RFI is also analyzed based on an envelope equation for the laser beam. Finally, the envelope equation is solved numerically, and anisotropic filamentation and self-focusing are illustrated.

Blast-wave-sphere interaction using a laser-produced plasma: an experiment motivated by supernova 1987A.

We present x-ray shadowgraphs from a high Mach number ( approximately 20) laboratory environment that simulate outward flowing ejecta matter from supernovae that interact with ambient cloud matter. Using a laser-plastic foil interaction, we generate a "complex" blast wave (a supersonic flow containing forward and reverse shock waves and a contact discontinuity between them) that interacts with a high-density (100 times ambient) sphere. The experimental results, including vorticity localization, compare favorably with two-dimensional axisymmetric hydrodynamic simulations.

Comparison of the upper gastrointestinal effects of etodolac and aspirin in healthy dogs.

Fifteen healthy castrated male dogs were separated into three treatment groups that were administered etodolac, aspirin and a placebo orally, respectively. All treatments were continued for 28 days. The animals were examined endoscopically on days 0, 3, 7, 10, 14, 17, 21, 24 and 28. There were no gastrointestinal mucosal lesions in either the etodolac or the placebo group, whereas some gastric lesions developed in the aspirin group after day 17. We considered that etodolac could be used for long-term treatments in dogs with fewer side-effects on the gastric mucosa than aspirin.

Pathological features of mucinous carcinoma of the breast are favourable for breast-conserving therapy.

AIM: The effectiveness of breast-conserving therapy for mucinous carcinoma has not been well documented. We examined clinical and pathological features of cases to determine whether patients with mucinous carcinoma were suitable candidates for this treatment. METHOD: Cases of pure type (n=52) and mixed type (n=24) mucinous carcinomas were reviewed with emphasis on the risk factors associated with local recurrences after breast-conserving therapy. RESULTS: Large pure mucinous carcinomas had a low incidence of extensive intraductal spreading (EIS). An inverse correlation existed between the incidence of EIS and tumour size (P<0.05). Comedo type EIS was infrequent (11%) in pure mucinous carcinoma. Incidences of lymphatic vessel invasion (4%) and nodal involvement (4%) were lower in pure mucinous carcinoma than in mixed carcinoma (P<0.05). No nodal involvement occurred in patients with pure mucinous carcinoma less than 3 cm in diameter. CONCLUSIONS: Patients with pure mucinous carcinomas, except those invading the local skin, are suitable candidates for breast-conserving therapy. Most pure mucinous carcinomas, including a large tumour up to 5 cm in diameter, can be treated with this therapy.

Distribution and characterization of vanilloid receptors in the rat stomach.

The cloned vanilloid receptor-1 (VR1) is recognized as a common molecular target for protons, noxious heat, and vanilloids. The presence of VR1 in the dorsal root, trigeminal, and nodose ganglia has been firmly established, but it is unclear in the gut, despite this VR1 may be important for gastric mucosal homeostasis. In this study we used an antibody and a radioligand to show the distribution of vanilloid receptors (VRs) in rat stomach and to characterize it. The deafferentiation of capsaicin-sensitive nerves in rats was induced by consecutive injections of capsaicin. VR1-immunopositive nerve endings were predominantly found in the mucous neck cells of the proliferation zone, and around blood vessels in the submucosa. Radioreceptor assay using [3H]-resiniferatoxin (RTX) revealed the existence of high affinity and single-class binding site in the membrane fractions of the mucosa. Capsaicin completely inhibited the specific binding of [3H]-RTX. Both the VR1 immunoreactivity and the receptor density of [3H]-RTX binding sites significantly reduced by the application of capsaicin for prolonged periods of time in the mucosa of rats. Our results indicate that VRs are expressed in the rat stomach, and suggest that they may be involved in mucosal protection by increasing cell proliferation and blood flow.

Clinical significance of noninvasive assessment of left ventricular diastolic function by Doppler echocardiography.

Transmitral flow velocity pattern obtained by the pulsed Doppler technique reflects left ventricular (LV) diastolic function, but an increase in left atrial pressure pseudonormalizes the flow pattern and masks diastolic dysfunction. We propose an index to assess LV diastolic function using color M-mode Doppler echocardiography and the base-line shift technique. This index, flow propagation velocity, represents the average velocity of early diastolic LV filling flow from the mitral orifice to mid-ventricle. In patients with ischemic heart disease and dilated cardiomyopathy including those with pseudonormalized transmitral flow pattern, flow propagation velocity had a good correlation with the time constant of early diastolic LV pressure decay (Tau), indicating that flow propagation velocity is a useful noninvasive parameter of diastolic function which does not pseudonormalize. We also found a significant correlation between flow propagation velocity and Tau in hypertrophic cardiomyopathy patients in contrast to inadequate or no correlation between each of the conventional parameters and Tau. In addition, our recent data suggest that flow propagation velocity was distinctly decreased even in the patients with hypertension who did not show significant increase in LV mass index. Flow propagation velocity is a unique noninvasive parameter of LV diastolic function, which can sensitively and accurately detect the diastolic impairment in patients with different types of cardiac diseases with various loading conditions.