Holography in de Sitter Space via Chern-Simons Gauge Theory.

In this Letter, we propose a holographic duality for classical gravity on a three-dimensional de Sitter space. We first show that a pair of SU(2) Chern-Simons gauge theories reproduces the classical partition function of Einstein gravity on a Euclidean de Sitter space, namely S^{3}, when we take the limit where the level k approaches -2. This implies that the conformal field theory (CFT) dual of gravity on a de Sitter space at the leading semiclassical order is given by an SU(2) Wess-Zumino-Witten model in the large central charge limit k→-2. We give another evidence for this in the light of known holography for coset CFTs. We also present a higher spin gravity extension of our duality.

Synthesis and In Vitro Evaluation of Novel Liver X Receptor Agonists Based on Naphthoquinone Derivatives.

We aimed to synthesize novel liver X receptor (LXR) agonists with potent agonist activity and subtype selectivity. Our synthetic scheme started with naphthoquinone derivatives, such as menadione and 2,3-dichloro-1,4-naphthoquinone. We introduced different substituents into the naphthoquinone structures, including aniline, piperidine, pyrrolidine, and morpholine, in one or two steps, and thus, we produced 14 target compounds. All 14 synthetic ligands were tested to determine whether they mediated LXR-mediated transcriptional activity. We investigated the transcriptional activity of each compound with two types of receptors, LXRα and LXRß. Among all 14 compounds, two showed weak LXRß-agonist activity, and two others exhibited potent LXRα-agonist activity. We also performed docking studies to obtain a better understanding of the modes of compound binding to LXR at the atomic level. In conclusion, we successfully synthesized naphthoquinone derivatives that act as LXRα/ß agonists and selective LXRα agonists.