[Complex application of indralin and ferrocin for the combined exposure on the organism of external gamma-irradiation and incorporation of 137Cs].

The summary of the study is that when using both medicines indraline doesn't influence the effectiveness of pherrocine in preventing of 137Cs accumulation in the main depositing/pooling organs. The radiation protecting medicine indraline used more intensive accumulation of radio nuclides in liver and kidney then a control. Accumulation rapidity and amount of 137Cs in liver and kidney depends on the time period between taking indraline and inflow of cesium into organism of animals. For the case when animals being exposured by external gamma-irradiation and incorporation of 137Cs the introduction of indraline without pherrocine is not advisable.

[On the problem of prophylaxis of late effects induced by internal irradiation using immunomodulators]. / K probleme profilaktiki pri pomoshchi immunomoduliatorov otdalennykh posledstvii, vyzvannykh vnutrennim oblucheniem.

Using the experimental modeling of late effects induced by intake of radionuclides (131I, 238,239Pu, 90Sr) the attempt to investigate the possibility of protection using immune modulators was made. Co-polymer of 2-methil-5-vinilprilidin and N-vinilpirrholidon (sovidon), G immunoglobulin and interferon, Fc fragment of immunoglobulin and S. parathyphi B. Breslau vaccine were used as immune modulators. The positive prophyletie influence of immune modulators was found for average life span, radiation action, immune status, of rates of occurrence and developments of breast tumors induced by 131I, 239Pu and 90Sr. At the same time the increase in osteosarcoma cumulative rate induced by immune modulators in case of body intake of 238Pu and 90Sr was registered.

[The state of dog's metabolism after long interval after oxide tritium administration]. / Sostoianie obmena veshchestv u sobak v otdalennye sroki vozdeistviia okisi tritiia.

An attempt to evaluate the influence of tritium oxide on the metabolism by some indices of lipid metabolism (common lipids, beta-lipoproteins, cholesterin), protein metabolism (cholinesterasa) and carbohydrate metabolism (blood sugar) was made. It was established that the introduction into organism of tritium oxide in the quantities, which could form lethal and sublethal doses of internal radiation, provoked the main changes of values of mentioned indices of metabolism. The character of metabolism changes in the remote period allows us to judge about the development of sclerosis processes, which can be the result of radiation-stipulated acceleration of organism aging.

[Study of the effect of a food additive Medetopect on metabolic kinetics of transuranic radionuclides in animal body]. / Izuchenie vliianiia pishchevoi dobavki "Medetopekt" na kinetiku obmena transuranovykh radionuklidov v organizme zhivotnykh.

The effect of Medetopect, a food additive, on the metabolic kinetics of transuranics (239Pu and 241Am) has been studied experimentally in white mongrel rats following chronic intake by ingestion. The Medetopect application has been shown to be advantageous for reduction of the 239Pu and 241Am absorption from and content of the gastrointestinal tract of the animals.

[Radionuclide biokinetics as a function of the age of experimental animals]. / Biokinetika radionuclidov kak funktsiia vozrasta éksperimental'nykh zhivotnykh.

Behaviour of radionuclides with different distribution types in the organism of animals of various ages was studied. Depending on the age of experimental animals, an essential difference in biokinetic parameters such as coefficients of absorbtion from gastro-intestinal tract, distribution and retention levels in critical organs, retention and excretion rates of radionuclides was found.

[The significance of modifying factors in evaluating the effect of radionuclides]. / Znachenie modifitsiruiushchikh faktorov pri otsenke vozdeistviia radionuklidov.

The authors provide the data obtained in experimental animals, pertaining to the influence of certain modifying factors on metabolism and biological effects induced by radioactive isotopes of iodine, by transuranium elements and beryllium. Out of all the modifying factors investigated, the form of the introduced compound and age turned out the most significant ones.

[The effect of age on the distribution of 241Am in the rat body]. / Vliianie vozrasta na raspredelenie 241Am v organizme krys.

In experiments with albino mongrel rats aged from 2 weeks to 1.5-2 years, the kinetics of 241Am distribution was studied after single intraperitoneal administration thereof. The content of 241Am in the skeleton was shown to decrease and in the liver to increase with age.

[Lung histopathology during plutonium-238 incorporation]. / Gistopatologiia legkikh pri inkorporatsii plutoniia-238.

In experiments with albino mongrel female rats a study was made of the response of the lungs to a single intratracheal injection of nitrate of 238Pu (0.4-740 kBq/kg). The nature of the inflammatory disease, the lymphoid tissue condition, pneumosclerosis occurrence, and the frequency and spectrum of lung tumors were shown to be a function of dose of the radionuclide administered.

Carcinogenic effects in rat progeny exposed perinatally to radionuclides.

The distribution of two transuranic elements, plutonium and americium, in pregnant rats and in their fetuses, and the carcinogenic effects seen in progeny exposed perinatally are discussed. The appearance of malignant tumours in the liver and skeleton corresponds to the pattern of deposition of these radionuclides in the body.

[Absorption of 249Bk from the gastrointestinal tract of rats]. / Vsasyvanie 249Bk iz zheludochno-kishechnogo trakta krys.

In experiments with albino mongrel female rats a study was made of the absorption of 249Bk from the gastrointestinal tract after a single per os administration. The bulk of 249Bk (96 per cent) administered either intravenously or per os was mainly deposited in the skeleton and liver. The value of 249Bk absorption from the gastrointestinal tract by days 4 and 8 following administration was 0.05 per cent.

[Absorption of 241Am in the gastrointestinal tract]. / O vsasyvanii 241Am iz zheludochno-kishechnogo trakta.

In experiments with rats a study was made of a number of factors influencing the resorption of 241Am from the gastrointestinal tract (GIT). The resorption of 241Am from GIT was found to be 120-245 times more intensive in neonatal rats, during the first 21 days after birth (a milk diet), than in adult animals. A milk diet for adult rats produced a 5-fold increase in the resorption of 241Am from GIT. The additional administration of digestive enzymes, as a homogenate from pancreas and small intestine, produced a 7--9-fold increase in the rate of 241Am resorption from GIT.

[Absorption from the gastrointestinal tract of rats of biologically incorporated 241Am found in fish]. / Vsasyvanie iz zheludochno-kishechnogo trakta krys "biologicheski inkorporirovannogo" 241Am, soderzhashchego v rybe.

In experiments on mongrel albino rats it was shown that the absorption of 241Am "biologically incorporated" in fish from the gastrointestinal tract amounted to 0.1% and exceeded by 4.5 times the intake of 241Am nitrate and by 6 times the absorption of 241Am administered in fish externally contaminated with americium 241.

[Metabolic kinetics and the biological action of 238Pu in the body of rabbits after intratracheal administration]. / Kinetika obmena i biologicheskoe deistvie 238Pu v organizme krolikov pri intratrakheal'nom vvedenii.

A study was made of the distribution and biological effect of 238Pu nitrate intratracheally administered to rabbits. The skeleton and liver were the main organs in which 238Pu was secondarily deposited to make 63.5 and 12.9%, respectively, of the total amount administered. For 60 days of observation 15.3% of the amount administered were excreted in feces and urine. With 238Pu dose of 520 kBq/kg acute radiation sickness developed while at a dose of 4 kBq/kg the life span of animals did not vary from the control.

[Modification of the process of resorption of alpha-emitting nuclides from the gastrointestinal tract depending upon the properties of administered compounds and the physiological state of rats]. / Modifikatsiia protsessov rezorbtsii alpha-izluchaiushchikh nuklidov iz zheludochno-kishechnogo trakta v zavisimosti ot svoistv vvodimykh soedinenii i fiziologicheskogo sostoianiia krys.

In experiments on rats a study was made of resorption from the gastrointestinal tract of simple salts, complex compounds and "biologically incorporated" forms of transuranium nuclides, the influence of age, pregnancy and chemically active substances (for instance, trivalent iron and ethyl alcohol) on this process.

[Dynamics of changes in the rat thymus gland as affected by intratracheal administration of 238Pu]. / Dinamika izmenenii vilochkovoi zhelezy krys pri intratrakheal'nom vvedenii 238Pu.

A study was made of the effect of intratracheal administration of 238Pu nitrate on rat thymus. Incorporation of an acutely effective dose of the radionuclide (740 kBq X kg-1) induced damages to all thymus structures. The optimal blastomogenic 238Pu amount (92.5 kBq X kg-1) administered during the chronic period of the disease caused complex changes of atrophic, hyper- and neoplastic nature the lymphoid component of the thymus being primarily damaged.

[The blastomogenic effect of 249Bk in rats]. / Blastomogennyi éffekt 249Bk u krys.

It is shown that 249Bk nitrate injected intraperitoneally in a wide range of doses to albino mongrel female rats is preferentially accumulated in the bony tissue (39.8%) and liver (18.4%). Incorporation of 249Bk to rats results in development of osteosarcomas, neoplasms of hemopoietic and lymphoid tissues, mammary tumours, thyroid and pituitary glands.