Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Brain Stimul ; 17(3): 668-675, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38740182

RESUMO

BACKGROUND: Virtually everyone is exposed to power-frequency MF (50/60 Hz), inducing in our body electric fields and currents, potentially modulating brain function. MF-induced electric fields within the central nervous system can generate flickering visual perceptions (magnetophosphenes), which form the basis of international MF exposure guidelines and recommendations protecting workers and the general public. However, magnetophosphene perception thresholds were estimated 40 years ago in a small, unreplicated study with significant uncertainties and leaving open the question of the involved interaction site. METHODS: We used a stimulation modality termed transcranial alternating magnetic stimulation (tAMS), delivering in situ sinusoidal electric fields comparable to transcranial alternating current stimulation (tACS). Magnetophosphene perception was quantified in 81 volunteers exposed to MF (eye or occipital exposure) between 0 and 50 mT at frequencies of 20, 50, 60 and 100 Hz. RESULTS: Reliable magnetophosphene perception was induced with tAMS without any scalp sensation, a major advantage as compared to tACS. Frequency-dependent thresholds were quantified using binary logistic regressions hence allowing to establish condition dependent probabilities of perception. Results support an interaction between induced current density and retinal rod cells. CONCLUSION: Beyond fundamental and immediate implications for international safety guidelines, and for identifying the interaction site underlying phosphene perception (ubiquitous in tACS experiments), our results support exploring the potential of tAMS for the differential diagnosis of retinal disorders and neuromodulation therapy.


Assuntos
Fosfenos , Estimulação Magnética Transcraniana , Percepção Visual , Humanos , Masculino , Adulto , Feminino , Fosfenos/fisiologia , Estimulação Magnética Transcraniana/métodos , Percepção Visual/fisiologia , Adulto Jovem , Limiar Sensorial/fisiologia , Campos Magnéticos , Pessoa de Meia-Idade
2.
Bioelectromagnetics ; 45(4): 171-183, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38348647

RESUMO

In recent years, an increasing number of studies have discussed the mechanisms of vestibular activation in strong magnetic field settings such as occur in a magnetic resonance imaging scanner environment. Amid the different hypotheses, the Lorentz force explanation currently stands out as the most plausible mechanism, as evidenced by activation of the vestibulo-ocular reflex. Other hypotheses have largely been discarded. Nonetheless, both human data and computational modeling suggest that electromagnetic induction could be a valid mechanism which may coexist alongside the Lorentz force. To further investigate the induction hypothesis, we provide, herein, a first of its kind dosimetric analysis to estimate the induced electric fields at the vestibular system and compare them with what galvanic vestibular stimulation would generate. We found that electric fields strengths from induction match galvanic vestibular stimulation strengths generating vestibular responses. This review examines the evidence in support of electromagnetic induction of vestibular responses, and whether movement-induced time-varying magnetic fields should be further considered and investigated.


Assuntos
Reflexo Vestíbulo-Ocular , Vestíbulo do Labirinto , Humanos , Estimulação Elétrica/métodos , Reflexo Vestíbulo-Ocular/fisiologia , Vestíbulo do Labirinto/fisiologia , Fenômenos Eletromagnéticos , Imageamento por Ressonância Magnética
3.
Phys Med Biol ; 67(1)2022 01 17.
Artigo em Inglês | MEDLINE | ID: mdl-34965521

RESUMO

Objective.Sensations of flickering light produced by time-varying magnetic fields or electric currents are called magneto- or electrophosphenes. Phosphene thresholds have been used in international guidelines and standards as an estimate of the thresholds of exposure that produce effects in the central nervous system (CNS). However, the estimated threshold values have a large range of uncertainty.Approach.Phosphene thresholds were approximated by simulating five phosphene threshold experiments. Retinal electric fields and currents induced by electric and magnetic stimulation were calculated using the finite element method and 14 anatomically realistic computational models of human heads.Main results.The radial component of retinal current density was determined to be in the range of 6.0-20.6 mA m-2. This study produces more accurate estimates for threshold current density in the retina using detailed anatomical models and the estimates had a reduced range of uncertainty compared to earlier studies.Significance.The results are useful for studying the mechanisms of retinal phosphenes and for the development of exposure limits for the CNS.


Assuntos
Radiometria , Retina , Eletricidade , Humanos , Campos Magnéticos , Modelos Anatômicos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...