1.
Angew Chem Int Ed Engl
; 40(15): 2903-2906, 2001 Aug 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11500904
2.
Angew Chem Int Ed Engl
; 40(15): 2903-2906, 2001 Aug 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29711998
RESUMO
Clinically relevant relaxivity enhancement of a magnetic resonance imaging (MRI) contrast agent has been achieved by using prodrug Gd3+ complexes (see picture, DTPA=diethylenetriaminepentaaceto). Enzymatic cleavage of lysine residues from the prodrug exposes a group that has a high affinity to human serum albumin and promotes enhanced relaxivity, thus enabling the detection of targets at submicromolar concentrations.