1.
Bioorg Khim
; 40(2): 157-65, 2014.
Artigo
em Russo
| MEDLINE
| ID: mdl-25895334
RESUMO
A method of the synthesis of RGD peptide derivatives containing glutaric or adipic residues linked with α-amino group of L-arginine and allowing carrying out their coupling with other biomolecules and nanoparticles.
Assuntos
Adipatos/química , Arginina/química , Glutaratos/química , Oligopeptídeos/síntese química , Sequência de Aminoácidos , Aminoácidos/química , Estrutura Molecular , Oligopeptídeos/química
2.
Amino Acids
; 22(2): 179-86, 2002.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12395185
RESUMO
The paper describes the synthesis of ( 2S, 4S)-4-(N-Ts)- and ( 2S, 4S)-4-(N-Boc)-phenylamino-5-oxoprolines (pyroglutamic acid). These derivatives have been shown to be useful for synthesis of their amides and peptides in spite of steric hindrances caused by bulky groups adjacent to the reaction centre. Under the conditions applied no lactam ring opening and no loss of stereochemical integrity of any of the chiral centres were observed, which has been confirmed by NMR techniques.