RESUMO
During pregnancy many physiologic changes occur that result in an increase in coagulation factors and a decrease in fibrinolytic activity. Because hemorrhage during pregnancy is a major cause of maternal morbidity, it is important to recognize and understand the pathophysiology of hereditary and acquired bleeding disorders. This article reviews von Willebrand's disease types 1, 2, and 3 and acquired hemophilia.
Assuntos
Coagulação Intravascular Disseminada , Hemorragia/etiologia , Complicações na Gravidez/etiologia , Feminino , Hemofilia A/complicações , Hemofilia A/diagnóstico , Hemofilia A/terapia , Humanos , Gravidez , Doenças de von Willebrand/complicações , Doenças de von Willebrand/diagnóstico , Doenças de von Willebrand/terapiaRESUMO
Protein C and S deficiency states predispose affected individuals to thrombosis, especially venous thrombosis of the lower extremities, usually beginning in the teenage years. Treatment of these patients is generally with oral anticoagulation, following initial heparinization. The classification of the deficiency states is dependent upon determination of the quantity and functional activity of either protein.
