RESUMO
A family with two nucleoside phosphorylase-deficient patients has been scored for the segregation of NP0 and the variable region 14p. The mose likely 14p:NP recombination fraction is 0.15 in males and 0.30 in females. There is no family data to assign the Pi:Gm linkage group to chromosome 14, but as immunoglobulin heavy chain has been assigned to this chromosome by somatic cell methods the most likely gene order is 14p:NP:Pi:Gm with Pi in 14q2 and Gm in 14(q23 leads to q32), but the order 14p:NP:Gm:Pi with Pi in 14(q24 leads to qter) and Gm in 14(q22 leads to q24) is not excluded. The available linkage data between biochemical markers on acrocentric chromosomes and their short arm markers suggest that there may be more recombination towards the ends of human chromosomes whether or not those ends carry centromeres.
Assuntos
Cromossomos Humanos 13-15 , Fosfotransferases/deficiência , Criança , Feminino , Genótipo , Humanos , Escore Lod , Masculino , Nucleosídeos/deficiência , Linhagem , Recombinação GenéticaRESUMO
Linkage between the Scianna blood group and the Rhesus blood group has been confirmed. Families demonstrating recombinants between U M P K and Sc suggest that U M P K lies between Sc and PGM1.
Assuntos
Antígenos de Grupos Sanguíneos/genética , Cromossomos Humanos 1-3 , Núcleosídeo-Fosfato Quinase/genética , Fosfotransferases/genética , Mapeamento Cromossômico , Feminino , Ligação Genética , Humanos , Masculino , Recombinação Genética , Sistema do Grupo Sanguíneo Rh-Hr/genética , Uridina MonofosfatoRESUMO
An investigation of 1088 unrelated British people to look for an association between alleles of the Rhesus blood group system and those of the Gm system gave the result expected for totally independent loci.
Assuntos
Antígenos de Grupos Sanguíneos , Ligação Genética , Imunoglobulina G/genética , Sistema do Grupo Sanguíneo Rh-Hr , Alelos , Humanos , Reino UnidoRESUMO
A family which segregates simultaneously for PGD, elliptocytosis, Rh, alphaFUC and PGM1 contains a recombinant suggesting that the loci lie in this order.
