Assuntos
Artérias/diagnóstico por imagem , Técnicas Cosméticas/efeitos adversos , Preenchedores Dérmicos/efeitos adversos , Embolia/prevenção & controle , Face/irrigação sanguínea , Adulto , Idoso , Preenchedores Dérmicos/administração & dosagem , Embolia/etiologia , Feminino , Voluntários Saudáveis , Humanos , Ácido Hialurônico/administração & dosagem , Ácido Hialurônico/efeitos adversos , Masculino , Pessoa de Meia-Idade , Necrose/etiologia , Necrose/prevenção & controle , Rejuvenescimento , Ultrassonografia Doppler em Cores/instrumentação , Adulto JovemAssuntos
Carcinoma de Célula de Merkel/secundário , Edema/etiologia , Mieloma Múltiplo , Segunda Neoplasia Primária/complicações , Neoplasias Retroperitoneais/patologia , Neoplasias Cutâneas/secundário , Carcinoma de Célula de Merkel/diagnóstico , Evolução Fatal , Humanos , Perna (Membro) , Masculino , Pessoa de Meia-Idade , Mieloma Múltiplo/tratamento farmacológico , Segunda Neoplasia Primária/diagnóstico , Neoplasias Cutâneas/diagnósticoRESUMO
BACKGROUND: The use of many of the standard skin-directed mycosis fungoides (MF) therapies on facial skin may be limited by site-specific increased risks of side effects, excessive inflammation, and ocular toxicity. OBJECTIVE: Our study aimed to describe the levels of erythema, scale, and induration of facial lesions in MF before and after low-dose high-dose-rate surface applicator brachytherapy and to examine the overall clinical response to brachytherapy. METHODS: A total of 23 facial MF lesions in 10 patients were treated with high-dose-rate brachytherapy doses of 4 Gy per session for a total of 2 fractions at our multidisciplinary cutaneous oncology clinic between August 17, 2009, and March 12, 2012. RESULTS: In all 23 lesions, dramatic clinical improvement was observed. Patients were followed up for a median of 6.3 months. No recurrences were reported in the follow-up period. LIMITATIONS: Long-term follow-up is lacking. Reassessment of all included patients at annual intervals for a period of at least 5 years is the authors' goal. CONCLUSION: Low-dose high-dose-rate brachytherapy using custom-made surface molds is a highly efficacious therapy in the treatment of facial lesions in MF.