Reverse re-modelling chronic heart failure by reinstating heart rate variability.

Heart rate variability (HRV) is a crucial indicator of cardiovascular health. Low HRV is correlated with disease severity and mortality in heart failure. Heart rate increases and decreases with each breath in normal physiology termed respiratory sinus arrhythmia (RSA). RSA is highly evolutionarily conserved, most prominent in the young and athletic and is lost in cardiovascular disease. Despite this, current pacemakers either pace the heart in a metronomic fashion or sense activity in the sinus node. If RSA has been lost in cardiovascular disease current pacemakers cannot restore it. We hypothesized that restoration of RSA in heart failure would improve cardiac function. Restoration of RSA in heart failure was assessed in an ovine model of heart failure with reduced ejection fraction. Conscious 24 h recordings were made from three groups, RSA paced (n = 6), monotonically paced (n = 6) and heart failure time control (n = 5). Real-time blood pressure, cardiac output, heart rate and diaphragmatic EMG were recorded in all animals. Respiratory modulated pacing was generated by a proprietary device (Ceryx Medical) to pace the heart with real-time respiratory modulation. RSA pacing substantially increased cardiac output by 1.4 L/min (20%) compared to contemporary (monotonic) pacing. This increase in cardiac output led to a significant decrease in apnoeas associated with heart failure, reversed cardiomyocyte hypertrophy, and restored the T-tubule structure that is essential for force generation. Re-instating RSA in heart failure improves cardiac function through mechanisms of reverse re-modelling; the improvement observed is far greater than that seen with current contemporary therapies. These findings support the concept of re-instating RSA as a regime for patients who require a pacemaker.

Noise-controlled signal transmission in a multithread semiconductor neuron.

We report on stochastic effects in a new class of semiconductor structures that accurately imitate the electrical activity of biological neurons. In these devices, electrons and holes play the role of K+ and Na+ ions that give the action potentials in real neurons. The structure propagates and delays electrical pulses via a web of spatially distributed transmission lines. We study the transmission of a periodic signal through a noisy semiconductor neuron. Using experimental data and a theoretical model we demonstrate that depending on the noise level and the amplitude of the useful signal, transmission is enhanced by a variety of nonlinear phenomena, such as stochastic resonance, coherence resonance, and stochastic synchronization.

Quantum interference of magnetic edge channels activated by intersubband optical transitions in magnetically confined quantum wires.

We investigate the photoresistance of a magnetically confined quantum wire in which microwave-coupled edge channels interfere at two pinning sites in the fashion of a Mach-Zehnder interferometer. The conductance is strongly enhanced by microwave power at B = 0 and develops a complex series of oscillations when the magnetic confinement increases. Both results are quantitatively explained by the activation of forward scattering in a multimode magnetically confined quantum wire. By varying the strength of the magnetic confinement we are able to tune the phase of electrons in the arms of the interferometer. Quantum interferences which develop between pinning sites explain the oscillations of the conductance as a function of the magnetic field. A fit of the data gives the distance between pinning sites as 11 µm. This result suggests that quantum coherence is conserved over a distance three times longer than the electron mean free path.

Electrically induced Raman emission from planar spin oscillator.

We predict that two-dimensional electrons confined by a magnetic field gradient resonantly transfer energy to the electromagnetic field by a process of inverse electron spin resonance that is realized when the frequency of an open orbit equals the Larmor frequency. The calculated emission spectra show multiple peaks modulated by strong optical nonlinearities whose frequencies may be tuned by the magnetic field gradient and the electron concentration.

Resistance resonance effects through magnetic edge states.

We report on the magnetoresistance of a two-dimensional electron gas subjected to an abrupt magnetic field gradient arising from a ferromagnetic stripe fabricated at its surface. A sharp resistance resonance effect is observed at B(p) due to the formation of two types of magnetic edge states that drift in opposite directions perpendicular to the magnetic field gradient for BB(p). A semiclassical drift-diffusion model gives a good description of the effects of the magnetic confinement on both the diagonal and off-diagonal components of the resistivity tensor.