Identification of GM3 as a marker of therapy-resistant periradicular lesions.

The purpose of this study was to analyze the profile of glycosphingolipids (GSLs) in periradicular lesions refractory to endodontic treatment. Sixteen periapical lesions were removed surgically from patients (experimental group) and compared with 10 samples of periodontal ligament removed from extracted intact third molars (control group). After the GSLs extraction and purification procedures were performed the neutral and acidic GSL fractions were analyzed by high-performance thin-layer chromatography and quantified by densitometry. Data reported herein show that: (i) tissues in the experimental group presented about twice as much GSLs as the control group; (ii) lesion tissues express lactoneotetraosylceramide, and lactofucopentaosyl (IV) ceramide, whereas these neutral GSLs are absent in normal tissues; and (iii) normal tissues express GT1b, whereas lesions cells do not express this ganglioside. In contrast lesion tissues express GM3, which is conspicuously absent in normal tissues.

A pioneering experience in Brazil: the creation of a center for assistance and research for medical residents (NAPREME) at the Escola Paulista de Medicina, Federal University of São Paulo.

The decision to develop a treatment service for medical residents at Escola Paulista de Medicina was influenced by three main factors: the suicide of four young doctors (2 residents) at this institution between 1995 and 1996, a research study that investigated stress among medical residents and the experience of other countries in response to similar problems. NAPREME has the following objectives: to help to reduce stress among residents, stimulate professional and personal development, prevent professional dysfunction and emotional disorders, offer psychological treatment, assess the tutors of residency programmes and develop research programmes to better identify risk factors for emotional problems during the residency period. We hope that by doing this the overall quality of the residency programme will improve, both for the professionals and the patients.

Bexiga psoica: consideracoes a respeito de 20 casos. / Psoas-hitch bladder: considerations on 20 cases

A tecnica da mobilizacao vesical para facilitar o reimplante ureterovesical e apresentada e seus resultados avaliados.Em nossas maos, a bexiga psoica mostrou os melhores resultados no reparo das lesoes do ureter distal

Priapismo - criacao de uma fistula espongio-cavernosa pela tecnica de Chester Winter. / Priapism: creation of a spongio-cavernous fistula by Chester Winter's technic

Os autores apresentam sua experiencia no tratamento do priapismo idiopatico com a realizacao do "shunt" cavernoso-glandar com agulha, enfatizando a simplicidade tecnica e os bons resultados obtidos

Colica nefritica. / Nephritic colic

Os autores descrevem a colica nefritica como uma sindrome, manifestacao das multiplas patologias intrinsecas ou extrinsecas que comprometem o trato urinario superior

Processos infecciosos agudos do rim. / Acute infectious processes of the kidney

Os autores comentam os processos infecciosos renais e suas complicacoes, ressaltando a alteracao de sua etiofisopatogenia apos o advento dos antibioticos