RESUMO
BACKGROUND: Alzheimer's disease is the most common neurodegenerative disease in the world, characterized by the progressive loss of neuronal structure and function, whose main histopathological landmark is the accumulation of ß-amyloid in the brain. OBJECTIVE: It is well known that exercise is a neuroprotective factor and that muscles produce and release myokines that exert endocrine effects in inflammation and metabolic dysfunction. Thus, this work intends to establish the relationship between the benefits of exercise through the chronic training of HIIT on cognitive damage induced by the Alzheimer's model by the injection of ß amyloid 1-42. METHODS: For this purpose, forty-eight male Wistar rats were divided into four groups: Sedentary Sham (SS), Trained Sham (ST), Sedentary Alzheimer's (AS), and Trained Alzheimer's (AT). Animals were submitted to stereotactic surgery and received a hippocampal injection of Aß1-42 or a saline solution. Seven days after surgery, twelve days of treadmill adaptation followed by five maximal running tests (MRT) and fifty-five days of HIIT, rats underwent the Morris water maze test. The animals were then euthanized, and their gastrocnemius muscle tissue was extracted to analyze the Fibronectin type III domain containing 5 (FNDC5), PPARG Coactivator 1 Alpha (PPARGC1A), and Integrin subunit beta 5 (ITGB5-R) expression by qRT-PCR in addition to cross-sectional areas. RESULTS: The HIIT prevents the cognitive deficit induced by the infusion of amyloid ß 1-42 (p<0.0001), causes adaptation of muscle fibers (p<0.0001), modulates the gene expression of FNDC5 (p<0.01), ITGB5 (p<0.01) and PPARGC1A (p<0.01), and induces an increase in peripheral protein expression of FNDC5 (p<0.005). CONCLUSION: Thus, we conclude that HIIT can prevent cognitive damage induced by the infusion of Aß1-42, constituting a non-pharmacological tool that modulates important genetic and protein pathways.
RESUMO
ABSTRACT The object of the present study was to carry out a literature review to analyze the influence of physical activity and dietary behavior on body mass index in school-age children and adolescents. A search was carried out using the PubMed and LILACS databases, in which 1,412 articles were found. After application of inclusion and exclusion criteria, 17 studies were selected for qualitative analysis. Overweight and obesity were related with incorrect dietary habits (skipping breakfast, consumption of foods with high fat contents and high-sugar soft drinks), low levels of physical activity and long hours devoted to sedentary activities (playing video games or watching TV) were also related.
RESUMEN El objetivo de este estudio fue analizar, mediante una revisión de la literatura, la influencia de la práctica de actividad física y del comportamiento dietético sobre el índice de masa corporal de niños y adolescentes en fase escolar. Se realizó una búsqueda en las bases PubMed y LILACS. Se encontraron 1.412 artículos. Tras la aplicación de los criterios de inclusión y exclusión fueron seleccionados 17 estudios para realizar un análisis cualitativo. El sobrepeso y la obesidad están relacionadas a una alimentación in-adecuada (saltar el desayuno, consumo de alimentos con alto contenido de grasa y de bebidas azucaradas), niveles bajos de actividad física y longas horas realizando actividad sedentaria (jugando video-juegos o visualizando la TV).
