Persistence of polybrominated biphenyls (PBB) in human post-mortem tissue.

Polybrominated biphenyl (PBB), a fire retardant, was accidentally substituted for an animal feed supplement in Michigan 10 years ago. This led to widespread livestock contamination and ultimately to contamination of virtually every human residing in the State at that time. In order to evaluate the extent of PBB persistence and distribution in human tissues 10 years after this accidental poisoning, a study was conducted on a series of autopsy cases from the Grand Rapids ("high" exposure) area of the State. No attempt was made to relate cause of death to PBB exposure or tissue concentration. Samples of 196 tissues from 15 subjects were analyzed for PBB content, and levels were determined by measurement of the hexabromobiphenyl peak using electron capture gas chromatography. Only 4 of the 196 samples analyzed did not have PBB concentration above the limit of detection (0.5 ng/g). As expected, fat and fat-rich tissue had the highest PBB concentration. Perirenal fat had the highest mean concentration (475 ng/g). Adrenal, atheromatus aorta and thymus had mean concentrations about half that of perirenal fat; all other tissues had mean concentrations one-tenth or less of perirenal fat. The results document that PBB is still present in human tissue and that PBB was distributed in all tissues examined. The PBB fat elimination half-time was estimated to be at least 7.8 years. If this is approximately correct, PBB will persist in tissues throughout the lifetime of humans so contaminated.

Risk factors for fatal heart attack in young women.

Deaths of 338 women at ages 15-44 years attributed to myocardial infarction (MI) on death certificates during an 18-month period in five metropolitan areas were investigated. Evidence of recent MI or evidence that death occurred suddenly was obtained for about half (163) from records of hospitals or medical examiners or from relatives. A case-control study (involving one deceased control, and one hospitalized living control) of risk factors for heart attack was then conducted using interviews with relatives and abstracts of records of hospitals and physicians identified by the relatives as sources of medical care. Information was obtained on history of prior MI, other heart disease, diabetes, thromboembolism, stroke, hypertension, high cholesterol, obesity, oophorectomy, oral contraception and cigarette smoking. Data are presented on the prevalence of these potential risk factors for the case group and each control group, and for subsets of cases consisting of those without prior heart disease, definite MI only, sudden death only, and white women only. Multivariate analyses identify somewhat different sets of risk factors and different levels of risk for the various subgroups. In general, the risk factors are those that have been reported for men, despite the major difference in level of mortality.

PIP: An investigation was conducted of the deaths of 338 women (15-44 years of age) attributed to myocardial infarction (MI) on death certificates during an 18-month period in the metropolitan areas of New York City, Los Angeles, Chicago, Philadelphia, and Detroit. For 163 of the women evidence of recent MI or evidence that death occurred suddenly was obtained from records of hospitals or medical examiners or from relatives. A case-control study (involving 1 decreased control and 1 hospitalized living control) of risk factors for heart attack was then conducted. Interviews with relatives were used along with abstracts of records of hospitals and physicians identified by the relatives as sources of medical care. Information was obtained on history of prior MI, other heart disease, diabetes, thromboembolism, stroke, hypertension, high cholesterol, obesity, oophorectomy, oral contraception (OC), and cigarette smoking. Data are presented on the prevalence of these potential risk factors for the case group and each control group, and for subsets of cases consisting of those without prior heart disease, definite MI only, sudden death only, and white women only. Multivariate analyses identify somewhat different sets of risk factors and different levels of risk for the various subgroups. The prevalence of several factors--high cholesterol, obesity, diabetes, hypertension, and thromboembolism--was higher in the total group of cases than those without a history of MI or other heart disease. In general, the risk factors were those that have been reported for men, despite a major difference in level of mortality.

Fatal myocardial infarction and the role of oral contraceptives.

The association between use of oral contraceptives (OC) and death from myocardial infarction (MI) in young women was investigated in a collaborative case-control study conducted in the five largest metropolitan areas in the US. Potential cases were identified from computer tapes of the National Center for Health Statistics. Controls were selected from among women who died from, or were hospitalized for, acute conditions other than heart disease or from accidents, and were matched to cases on age, geographic area, and year of death. Information on cause of death, personal characteristics, OC use, and the presence of conditions predisposing to MI was obtained from interviews with relatives and abstracts of hospital, clinic and physician records. Odds ratios as approximations to relative risks for fatal MI in relation to OC use, and the associated 95% confidence limits, were calculated overall and for subgroups determined by demographic and health history characteristics. Odds ratios in the total study population were not significantly different from one. However, odds ratios significantly different from one were found when attention was restricted to white subjects without contraindications to OC use, andincluding only those cases whose deaths were attributed to MI with the greatest degree of certainty. Smoking was found to be a significant risk factor for fatal MI.

PIP: A collaborative case-control study was conducted in the 5 largest metropolitan areas in the United States in order to investigate the association between oral contraceptive (OC) use and death from myocardial infarction (MI) in young women. Potential cases were identified from computer tapes of the National Center for Health Statistics. The controls were selected from among women who died from, or were hospitalized for, acute conditions other than heart disease or from accidents; they were matched to cases on age, geographic area, and year of death. The population of study cases was defined to be all women, age 15-44, who died of an acute MI during the January 1974-June 1975 period. 163 cases were classified as either MI or sudden death (SD). Information regarding cause of death, personal characteristics, OC use, and the presence of conditions predisposing to MI was obtained from interviews with relatives and abstracts of hospital, clinic and physician records. Odds ratios as approximations to relative risks for fatal MI in relation to OC use, and the associated 95% confidence limits, were calculated overall and for subgroups determined by demographic and health history characteristics. Odds ratios in the total study population were not significantly different from 1, but odds ratios significantly different from 1 were found when attention was restricted to white subjects without contraindications to OC use, and including only those cases whose deaths were attributed to MI with the greatest risk of certainty. A signficant risk factor for fatal MI was smoking. The data suggest that use of OCs may increase the risk of death from MI.

An estimate of the course of herpes simplex virus encephalitis.

Serologic responses, physical findings, and survival were studied in 51 cases of proved (14 patients) or presumptive (37 patients) herpes simplex encephalitis occurring in North America between 1965 and 1972. On the basis of a statistical analysis of 16 serological parameters tested in both groups, presumptive cases are likely similar to definitive cases. Using this assumption, the following tentatives conclusions are possible. Complement-fixing antibodies may be more sensitive measures of rises in anti-herpes simplex virus antibodies than are conventional or complement-requiring neutralizing or passive hemagglutinating antibodies. Mortality in herpes simplex virus encephalitis may vary from 0 to 80% and may be predictable depending upon the occurrence of seizures, paralysis and coma. Coma seems to dictate the dour prognosis. When 51 cases of herpes simplex virus encephalitis reported in the literature by others between 1944 and 1972 were analyzed by this method, a comparably varied mortality was obtained. It did not appear that treatment with idoxuridine increased the likelihood of survival.

Historia del psicoanálisis: III. Edward Hitschmann, Oskar Pfister, Hanns Sachs, Moshe Woolf, Abraham Aren Brill, Smith Ely Jelliffe / Psychoanalytic pioneers

Este libro ofrece al lector la oportunidad de adquirir una auténtica información de la vida y el pensamiento de siete autores de primera línea

Historia del psicoanálisis: III. Edward Hitschmann, Oskar Pfister, Hanns Sachs, Moshe Woolf, Abraham Aren Brill, Smith Ely Jelliffe / Psychoanalytic pioneers

Este libro ofrece al lector la oportunidad de adquirir una auténtica información de la vida y el pensamiento de siete autores de primera línea