1.
Bioorg Med Chem Lett
; 19(1): 17-20, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19036583
RESUMO
A small molecule inhibitor of beta-secretase with a unique binding mode has been developed. Crystallographic determination of the enzyme-inhibitor complex shows the catalytic aspartate residues in the active site are not engaged in inhibitor binding. This unprecedented binding mode in the field of aspartyl protease inhibition is described.