Localization of manserin, a secretogranin II-derived neuropeptide, in the oviduct of female rats.

Gynecological disorders related to menstrual cycle may be affected by stress and can cause infertility. Manserin is a stress-related neuropeptide that is present in the neuroendocrine system. In the present study, we determined the localization of manserin in the oviduct of adult Wistar rats using immunohistochemical techniques. Manserin was detected on the surface of the epithelium of the oviduct, but not in the ovary and uterus. Localization of manserin was specific to a large portion of the isthmus and to a small portion of the ampulla. These results suggest that manserin localizes to secretory cells in the oviduct and may be involved in stress-induced gynecological disorders.