1.
Org Biomol Chem
; 12(38): 7489-93, 2014 Oct 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25159865
RESUMO
A modular synthetic method for bis- and tris-1,2,3-triazoles that include a benzotriazole structure was developed on the basis of sequential azide-aryne and azide-alkyne cycloadditions. The key to success was efficient halogen-metal exchange reaction-mediated generation of aryne from ortho-iodoaryl triflates bearing a base-sensitive terminal alkyne moiety, which was achieved using trimethylsilylmethyl Grignard reagent.