The ReIationship of Mean PIateIet VoIume and Sudden SensorineuraI Hearing Loss / 听力学及言语疾病杂志

Objective Our aim was to investigate the association between sudden sensorineural hearing loss (SSHL)and mean platelet volume (MPV)values,in order to evaluate the etiology of SSHL.Methods This study included 40 patients with SSHL in our ward between Jan.2012 and Jan.2014 and 30 age- and sex-matched healthy subjects were included as controls.The correlation among the levels of the number of platelets,mean plate-let volume(MPV),platelet distribution width (PDW)was evaluated in the two groups.ResuIts The platelet count was significantly lower in the SSHL than the control group(212.0±47.9 versus 237.8±46.2 ×109/L).MPV and PDW were significantly higher in SSHL(10.9±0.8 versus 10.3±0.8 fL;12.9%±2.0% versus 12.0%±1.3 %). The SSHL patients were divided two subgroups:the mild-moderate subgroup (hearing loss 25~70 dB)and the se-vere subgroup(hearing loss≥70 dB).The MPV values were insignificantly different between the two subgroups(11. 0±1.1 fL versus 10.8 ±1.0 fL).Compared to the control group,the two subgroups had both significant differ-ences in MPV.ConcIusion High MPV values are a risk factor for thrombotic vascular diseases.Considering the in-creased MPV levels,SSHL appears to be characterized by ischaemic or thrombotic events.

The severity of obstructive sleep apnea and hypopnea syndrome in different sleep stage / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#This study aimed to inspect the hypothesis that obstructive sleep apnea and hypopnea syndrome (OSAHS) was commonly worse in REM sleep than in NREM sleep stage, and also to analyze the relevance with the risk factors of OSAHS.@*METHOD@#One hundred eighteen patients diagnosed as OSAHS by overnight polysomnography (PSG) were studied retrospectively. The severity of OSAHS in REM versus NREM sleep was compared. Then the patients were divided into two groups: AHI(REM) > or = AHI(NREM) group, and AHI(REM) < AHI(NREM) group, and the two groups were compared in age, sex, BMI, AHI, AHI supine, oxygen desaturation and duration of apnea.@*RESULT@#There was no significant difference between AHI(REM) and AHI(NREM). AHI(REM)/AHI(NREM) was 1.0 +/- 0.5. A higher AHI NREM than AHI REM group was found in 55.9% of the 118 patients with OSAHS. There were no differences between the clinical and PSG founding of two groups.@*CONCLUSION@#The severity of OSAHS is not greatly influenced by sleep stage.

Clinical features of OSAHS closely associated with supine position / 中国耳鼻咽喉头颈外科

OBJECTIVE To study the clinical features of OSAHS patients closely associated with supine position. METHODS The clinical data of 105 patients with OSAHS diagnosed by overnight polysomnography(PSG)were retrospectively studied. The patients were divided in two groups: the positional patients(PP)group, those patients who had a apnea-hypopnea index(AHI) that was at least two times higher than the lateral AHI, and the non-positional patients(NPP)group, those patients in whom the AHI in the supine position was two times less than that in the lateral position, and the two groups were compared with age, BMI and the severity of OSAHS. RESULTS The difference of age and BMI were not significant between the two groups[(40.4?10.5)year versus(37.0?10.6) year,(28.2?3.8)kg/m2 versus(29.1?3.0)kg/m2]. There was significantly different in AHI between two groups[(36.8?25.4)/h versus (51.2?29.0)/h ]. AHIsupine and AHInot-supine was significantly different in mild and moderate OSAHS patients [(23.9?13.8) /h versus(12.4?10.1)/h ]. CONCLUSION Mild and moderate OSAHS patients are mainly PP. Positional therapy should play an important role in treatment of mild and moderate patients.