Recent Trends and Advances in Additive-Mediated Composting Technology for Agricultural Waste Resources: A Comprehensive Review.

Agriculture waste has increased annually due to the global food demand and intensive animal production. Preventing environmental degradation requires fast and effective agricultural waste treatment. Aerobic digestion or composting uses agricultural wastes to create a stabilized and sterilized organic fertilizer and reduces chemical fertilizer input. Indeed, conventional composting technology requires a large surface area, a long fermentation period, significant malodorous emissions, inferior product quality, and little demand for poor end results. Conventional composting loses a lot of organic nitrogen and carbon. Thus, this comprehensive research examined sustainable and adaptable methods for improving agricultural waste composting efficiency. This review summarizes composting processes and examines how compost additives affect organic solid waste composting and product quality. Our findings indicate that additives have an impact on the composting process by influencing variables including temperature, pH, and moisture. Compost additive amendment could dramatically reduce gas emissions and mineral ion mobility. Composting additives can (1) improve the physicochemical composition of the compost mixture, (2) accelerate organic material disintegration and increase microbial activity, (3) reduce greenhouse gas (GHG) and ammonia (NH3) emissions to reduce nitrogen (N) losses, and (4) retain compost nutrients to increase soil nutrient content, maturity, and phytotoxicity. This essay concluded with a brief summary of compost maturity, which is essential before using it as an organic fertilizer. This work will add to agricultural waste composting technology literature. To increase the sustainability of agricultural waste resource utilization, composting strategies must be locally optimized and involve the created amendments in a circular economy.

Nitrogen fertilizer application rates and ratios promote the biochemical and physiological attributes of winter wheat.

Improper optimization of the rates and ratios of nitrogen application reduces grain yields and increases the nitrogen loss, thereby affecting environmental quality. In addition, scarcer evidence exists on the integrative approach of nitrogen, which could have effects on the biochemical and physiological characteristics of wheat. Treatments were arranged as nitrogen (N) rates of 00, 75, 150, 225, and 300 kg ha-1 in the main plots, and different nitrogen ratios were organized in subplots at 5:5:0:0 and 6:4:0:0, which were applied at the sowing, jointing, flowering, and grain filling stages. The results revealed that 225 kg N ha-1 significantly enhanced the stomatal conductance (G s), photosynthetic rate (P n), intercellular CO2 (C i), transpiration rate (T r), and total chlorophyll by 28.5%, 42.3%, 10.0%, 15.2%, and 50%, receptively, at the jointing stage in comparison to the control (0 kg N ha-1). Nitrogen application of 225 kg ha-1 increased the soil-plant analysis development (SPAD) value and the chlorophyll a, chlorophyll b, and carotenoid contents of winter wheat under the 6:4:0:0 ratio. The trend of the photosynthetic characteristics was observed to be greater at the 6:4:0:0 fertilization ratio compared to that at 5:5:0:0. The photosynthetic rate was significantly associated with the biochemical and physiological characteristics of winter wheat. In conclusion, the nitrogen dose of 225 kg ha-1 and the ratio of 6:4:0:0 (quantity applied at the sowing, jointing, flowering, and grain filling stages) effectively promoted the photosynthetic and other physiological characteristics of winter wheat.

Perception of dental students towards the online method of dental education during the COVID-19 pandemic.

BACKGROUND: The COVID-19 pandemic has changed the education system drastically. The shift from traditional learning to online mode during the quarantine period affected dental education substantially. The present study aimed to determine the impact of online learning on dental education and the potential challenges being faced by the dental students. METHODS: An online survey-based questionnaire was distributed to 103 BDS students and feedback was recorded. RESULTS: The study yielded a response rate of 57% comprising of female(56%)and male(44%) respondents. The participants were categorized into two groups with age brackets of 22 years& above. Majority of the female students (86.2%) were more inclined towards offline learning than male students (57.8%) (p = 0.001). More predilection for offline mode was observed in 83% of the students (>22 years of age) than 66.1%students (<22 years) (p = 0.05).BDS 1st (59.6%),2nd (74.1%) 3rd (93.8%)& 4th year (100%) students preferred offline mode for exams (p = 0.005). Most of the students (77.7%) including male (86.7%) and female (70.6%) (p = 0.05) strongly disagreed to continue E-learning in future. The students (<22 years) (98.2%) were more accessible to the internet than students (>22 years) (93.2%) (p = 0.02). The students (>22 years) found more difficulty in using different online platforms (87.2%) than students (<22 years) i.e., 69.6% (p = 0.03).BDS 3rd and 4th year (100%) appeared for the exams in greater numbers than BDS 1st year (76.6%) and 2nd year (92.6%) (p = 0.02). CONCLUSION: Online learning had a detrimental impact on dental education. The students agreed that online mode cannot substitute conventional face-to-face learning.

Recent global warming as a proximate cause of deforestation and forest degradation in northern Pakistan.

Instrumental climatological records such as weather stations data of northern areas of Pakistan are not sufficient to assess the forest extreme events reliably. To understand the past climatic variability, tree ring width based climatic reconstruction is the best alternative to trace climate variability that goes back in time. Quercus Incana is the most sensitive species to drought and climatic variation in northern Pakistan. However, very little research quantifies the rate of ongoing climatic changes. A total of 65 tree cores were collected from two sites to understand the radial growth of Q. Incana to extreme drought events. The radial growth is mainly affected by high temperatures during May-July. In addition, radial growth exhibits a positive correlation with February-June precipitation while it is negatively correlated with the September precipitation. The radial growth decrease, particularly in harsh climatic conditions. The reconstructed tree ring record was strongly coherent with the May-June self-calibrated Palmer drought severity index (scPDSI) and reliable in reconstructing drought variability for the period 1750-2014. During the past 264 years, wet periods were found during 1980-2010, 1812-1836, and 1754-1760, while dry periods were found during 1896-1922, 1864-1876, and 1784-1788. Our reconstruction explains 39.8% of the scPDSI variance. The extreme drought and wet years we arrived at were in close agreement with the drought and wet periods that occurred in northern Pakistan. Wavelet analysis revealed drought variability at periodicities of 2.2-2.5, 3.3, 3-4, 16.7, 16.8, and 68-78.8 years. Hence it is concluded that deforestation and forest degradation rate increased with extreme drought and wet years. Overall, the variation of drought in northern Pakistan seems to have been affected due to El Nino south oscillation, Pacific decadal oscillation, or Atlantic multi-decadal oscillations.

Quantifying the effects of co-composting organic biomass mixtures with inorganic amendments to obtain value-added bio-products.

Co-digestion of organic biomass mixed with inorganic amendments could have an impact on composting dynamics. Various studies highlighted fertilizers' role as an additive to lesser the nitrogen loss, while some studies focused on the addition of fertilizers to enhance the efficiency. The changes in carbon, nitrogen components, and humic substances during the organic-inorganic co-compost process were seldom studied. Clarifying these changes might help improve the production process and compost nutrients contents. Thus, this study's purpose is to investigate the effects of inorganic amendments on compost characteristics, compost temperature, biochemical methane production (BMP), and nutritional contents. The inorganic phosphorous (P), sulfur (S), and sulfur solubilizing agent (SSA) were added to Farmyard manure (FYM) mixed with biodegradable waste (BW), including wheat straw, corn stalks, and green lawn waste. The P and S amended treatments were carried out into two sets, with and without SSA. The mixed feedstocks were added in the insulated RBC composting pit (15 x 15 x 10 feet). The compost material's moisture content was maintained 50-65% during the entire composting process for optimum waste digestion i.e., the moisture content (MC) of FYM was 82.7% and for BW ranged 8.8-10.2%, while the C/N ratio was found 10.5 for FYM, 74.5 for wheat straw, 83.5 for corn stalks, and 84.8 for lawn waste. At the condition of compost maturity, the inorganic amendments have no significant effect on composted material's moisture content. The maximum organic matter of 69.7% and C/N ratio of 44.6 was measured in T1. On the 6th day of composting, the temperature reached to thermophilic range (>45 oC) in all the treatments due to aeration of compost increased microbial activities and waste decomposition rate and decreased gradually to mesophilic range (35-45 oC) because the supply of high-energy compounds becomes exhausted. The highest temperature was reached in T4 (58 oC) and lowest in CT (47 oC). The significantly maximum methane of 8.95 m3 and biogas burning was 818 minutes in CT, followed by T1 and T4. The results of this study revealed that P enriched compost is a feasible and sustainable way to overcome P deficiency in the soil as well as in plants and best way to use low-grade P and organic waste material.

Erratum: Molecular docking and pharmacokinetic evaluation of natural compounds as targeted inhibitors against Crz1 protein in Rhizoctonia solani.

[This corrects the article on p. 227 in vol. 15, PMID: 31285645.].

Evaluation of methane production and energy conversion from corn stalk using furfural wastewater pretreatment for whole slurry anaerobic co-digestion.

In this study, corn stalk (CS) was pretreated with furfural wastewater (FWW) for whole slurry anaerobic digestion (AD), which increased the degradability of CS components, changed the parameters in pretreatment slurry and improved the biochemical methane potential (BMP). The ultimate goal was to optimize the time and temperature for FWW pretreatment and evaluate whether FWW pretreatment is feasible from BMP and energy conversion. The results of path analysis suggested that lignocellulosic degradability (LD) was the main factor affecting methane production with the comprehensive decision of 0.7006. The highest BMP (166.34 mL/g VS) was achieved by the pretreatment at 35 °C for 6 days, which was 70.36% higher than that of control check (CK) (97.64 mL/g VS) and the optimal pretreatment condition was predicted at 40.69 °C for 6.49 days by response surface methodology (RSM). The net residual value (NRV) for the pretreatment of 35 °C and 6 days was the highest (0.6201), which was the most appropriate condition for AD in real application.

Molecular docking and pharmacokinetic evaluation of natural compounds as targeted inhibitors against Crz1 protein in Rhizoctonia solani.

Crz1p regulates Calcineurin, a serine-threonine-specific protein phosphatase, in Rhizoctonia solani. It has attracted consideration as a novel target of antifungal therapy based on studies in numerous pathogenic fungi, including, Cryptococcus neoformans, Candida albicans and Aspergillus fumigatus. To investigate whether Calcineurin can be a useful target for the treatment of Crz1 protein in R. solani causing wet root rot in Chickpea. The work presented here reports the in-silico studies of Crz1 protein against natural compounds. This study Comprises of quantitative structure-toxicity relationship (QSTR) and quantitative structure-activity relationship (QSAR). All compounds showed high binding energy for Crz1 protein through molecular docking. Further, a pharmacokinetic study revealed that these compounds had minimal side effects. Biological activity spectrum prediction of these compounds showed potential antifungal properties by showing significant interaction with Crz1. Hence, these compounds can be used for the prevention and treatment of wet root rot in Chickpea.

Structure-based virtual screening and molecular docking for the identification of potential novel EGFRkinase inhibitors against ovarian cancer.

Epidermal Growth Factor Receptor (EGFR) is, for the most part, deregulated and over-communicated in ovarian disease, which is legitimately connected with STAT3 enactment that prompts the collection of hostile to apoptotic occasions and along these lines, docetaxel medicate obstruction happens. As to, expanding of docetaxel medicate affectability by focusing on EGFR receptor alongside docetaxel drugs is one of the real techniques in ovarian disease treatment. In this specific circumstance, utilizing atomic recreation considers, the present examination depicted the auxiliary and pragmatic properties of IBS Database mixes as a potential inhibitor of EGFR tyrosine kinase, and furthermore ADMET had researched its Pharmacokinetic profile. As indicated by the outcomes, STOCK1N-98911, STOCK1N- 98869, and STOCK1N-98896 have appeared tremendous restricting vitality by associating with critical build ups in the dynamic site. Natural movement range forecast of these mixes indicated potential anticancer properties by demonstrating important collaboration with EGFR tyrosine kinase. Besides, the investigation is likewise valuable for further clinical based examinations and furthermore for the approval of toxicological and pharmacokinetic contemplate.

Furfural wastewater pretreatment of corn stalk for whole slurry anaerobic co-digestion to improve methane production.

Previous studies showed that excellent anaerobic digestion performance could be achieved using acid pretreatment, whereas the development of acid pretreatment was limited by high cost of acid consumption and severe operation. The aim of this study consisted in expanding the possibilities of low-cost acid pretreatment method for anaerobic digestion. For this, the feasibility of substituting conventional acid pretreatment with furfural wastewater was verified, and the whole slurry anaerobic digestion was performed to improve the production of methane. The furfural wastewater was used to pretreat crop stalk at different ambient temperatures (20, 35, 50°C) for different time periods (0, 3, 6, 9days). Subsequently, all treated and untreated crop stalk were digested at 35°C for 25days. According to experimental data showed that the dissimilar degradability of compositions for crop stalk was due to furfural wastewater pretreatment, and the reducing sugar content, volatile fatty acid content, pH during pretreatment phase, and their initial maximum & minimum values in anaerobic digestion phase were changed, which made a significant difference in methane production. The highest total methane production of anaerobic digestion (196.68mL/g VS) was achieved by the treatment at 35°C for 6days, which was 59.28% higher than untreated crop stalk (123.48mL/g VS). On the whole, the results showed that furfural wastewater pretreatment followed by the whole slurry anaerobic co-digestion was feasible and could contribute to application value for anaerobic digestion industry while providing an effective way for the treatment of furfural wastewater.

Langerhans Cell Histiocytosis in an Infant Mimicking a Lymphoma at Presentation.

Langerhans cell histiocytosis (LCH) is a rare disorder characterized by proliferation and accumulation of clonal dendritic cells with varied clinical presentation and an unpredictable course. We report a 5-month-old infant with LCH who presented with severe respiratory distress, a large mediastinal mass, significant generalized lymphadenopathy, and hepatosplenomegaly. Lymphoma, especially T cell lymphoblastic lymphoma, can present with superior mediastinal syndrome needing urgent empirical therapy without biopsy. However, lack of response prompted a biopsy which confirmed it to be a case of LCH and that leads to appropriate therapy and survival. There have been reports of LCH presenting with isolated mediastinal mass or with generalized lymphadenopathy, but the combined presentation of generalized lymphadenopathy with large mediastinal mass, hepatosplenomegaly, and fever in an infant has rarely been reported. Conclusion. LCH should also be considered in the differential diagnosis of an infant presenting with generalized lymphadenopathy, mediastinal mass, hepatosplenomegaly, and fever.

Protective role of zinc-metallothionein (Zn-MT) in iron nitrilotriacetate (Fe-NTA)-induced renal oxidative damage.

Several studies have shown the role of thiol-rich proteins especially metallothionein (MT) in the therapeutic interventions against oxidative damage. Previously, we have provided strong evidence for the involvement of ROS in iron nitrilotriacetate (Fe-NTA)-induced renal toxicity, which may have relevance to its carcinogenicity. The purpose of this study was to evaluate the role of zinc metallothionein (Zn-MT) on the protection against Fe-NTA-induced renal oxidative damage. The results demonstrate that Zn-MT pretreatment provided protection against Fe-NTA-induced mortality in mice (40% protection). Similarly, Zn-MT pretreatment also provided protection against Fe-NTA-induced lipid peroxidation (26% inhibition, P < 0.001). It is proposed that Zn-MT protects kidney tissue against the noxious effect of Fe-NTA primarily by interference with lipid peroxides. It is concluded that Zn-MT may serve as an excellent physiological antioxidant against Fe-NTA-mediated renal oxidative damage.

Superoxide dismutase--applications and relevance to human diseases.

Reactive oxygen species, such as superoxide radicals, are thought to underlie the pathogenesis of various diseases. Almost 3 to 10% of the oxygen utilized by tissues is converted to its reactive intermediates, which impair the functioning of cells and tissues. Superoxide dismutase (SOD) catalyzes the conversion of single electron reduced species of molecular oxygen to hydrogen peroxide and oxygen. There are several classes of SOD that differ in their metal binding ability, distribution in different cell compartments, and sensitivity to various reagents. Among these, Cu, Zn superoxide dismutase (SOD1) is widely distributed and comprises 90% of the total SOD. This ubiquitous enzyme, which requires Cu and Zn for its activity, has great physiological significance and therapeutic potential. The present review describes the role of SODs, especially Cu, Zn SOD, in several diseases, such as familial amyotrophic lateral sclerosis (FALS), Parkinson's disease, Alzheimer's disease, dengue fever, cancer, Down's syndrome, cataract, and several neurological disorders. Mutations in the SOD1 gene cause a familial form of amyotrophic lateral sclerosis. The mechanism by which mutant SOD1 causes the degeneration of motor neurons is not well understood. Transgenic mice expressing multiple copies of FALS-mutant SOD1s develop an ALS-like motor neuron disease. Vacuolar degeneration of mitochondria has been identified as the main pathological feature associated with motor neuron death and paralysis in several lines of FALS-SOD1 mice. Various observations and conclusions linking mutant SOD1 and FALS are discussed in this review in detail.