1.
Chem Commun (Camb)
; 55(37): 5339-5342, 2019 May 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30973558
RESUMO
A tunable chemoenzymatic strategy provides access to the entire class of magic spot nucleotides and modified analogues. The approach combines chemoselective bisphosphorylations using phosphoramidites with regioselective ribonuclease T2 cyclo-phosphate hydrolysis, leading to flexible and simple gram-scale operations.