RESUMO
Two sets of heterofunctional dendritic frameworks displaying an inversed and exact number of ene and azide groups have successfully been synthesized and post-functionalized with biorelevant molecules. Their facile scaffolding ability enabled the fabrication of soft and azide functional dendritic hydrogels with modulus close to muscle tissue. The dendritic scaffolds are furthermore shown to be promising primers for the development of novel bone fracture stabilization adhesives with shear strengths succeeding commercial Histroacryl®.
Assuntos
Cimentos Ósseos/química , Cimentos Ósseos/uso terapêutico , Substitutos Ósseos/química , Substitutos Ósseos/uso terapêutico , Fixação Interna de Fraturas/métodos , Osteoblastos/efeitos dos fármacos , Fenóis/química , Adesivos Teciduais/química , Animais , Cimentos Ósseos/farmacologia , Substitutos Ósseos/farmacologia , Linhagem Celular , Sobrevivência Celular/efeitos dos fármacos , Teste de Materiais , Osteoblastos/fisiologia , Fenóis/farmacologia , Fenóis/uso terapêutico , Ratos , Adesivos Teciduais/farmacologiaRESUMO
A fourth wheel: Two sets of bifunctional AB(2)C dendrimers having internal acetylene/azides and external hydroxy groups were constructed utilizing benign synthetic protocols. An in situ postfunctionalization strategy was successfully carried out to illustrate the chemoselective nature of these dendrimers. The dendrimers were also transformed into dendritic nanoparticles or utilized as dendritic crosslinkers for the fabrication hydrogels.