Phenotype correction of Ir-genic control of immune response to (T,G)-A-L conjugated to synthetic polyelectrolytes.

Experiments in CBA (H-2k) and C57BL/6 (H-2b) strains of mice have shown (T,G)-A-L covalently bound to synthetic polyelectrolytes possessing immunoadjuvant effect to induce a pronounced antibody and cell-mediated immune response irrespective of murine genotype. When conjugated to the polyelectrolytes (T,G)-A-L was also found to acquire the properties of a highly immunogenic thymus-independent antigen. Thus, (T,G)-A-L-synthetic polyelectrolytes conjugates manifested the effects of highly immunogenic thymus-independent antigens inducing a potent Ir-1-independent immune response. It provided for the transformation of genetically low responder individuals into high responder ones.