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J Comp Neurol ; 410(4): 571-85, 1999 Aug 09.
Artigo em Inglês | MEDLINE | ID: mdl-10398049

RESUMO

Vestibulospinal axon collaterals in C1 and C2 were stained following injections of Phaseolus vulgaris leucoagglutinin (PHA-L) into the lateral vestibular nucleus (LVN). The distribution and geometry of collaterals within three regions of the ventral horn were determined at the light microscopic level. These processes were subsequently examined at the electron microscopic level to define the relationship between their ultrastructural characteristics and their geometry and location. All round or elliptical varicosities, whose diameters exceeded the diameter of the adjacent axon shaft by a factor of two, as measured at the light microscopic level, contained synaptic vesicles and contacted dendrites or somata. These varicosities accounted for 82% of labelled axon terminals found at the electron microscopic level. Thus, axon terminals stained with PHA-L can be identified reliably at the light microscopic level, but synaptic density will be slightly underestimated. One-hundred and thirty-eight axon terminals were classified as excitatory or inhibitory on the basis of well-established morphological criteria (e.g., vesicle shape). Placed in the context of previous physiological observations describing the excitatory or inhibitory actions of medial and lateral vestibulospinal tract (MVST and LVST) neurons, our results suggest that projections from the LVN to the ipsilateral ventral horn originate primarily from the LVST. These connections are excitatory. Ipsilateral connections via the MVST are inhibitory and are largely confined to a region near the border of laminae VII and VIII. Most axon terminals in the contralateral ventral horn were inhibitory. This result indicates that the LVN is the source of a specific subset of crossed MVST axons with inputs from the posterior semicircular canal.


Assuntos
Gatos/fisiologia , Terminações Nervosas/fisiologia , Medula Espinal/fisiologia , Transmissão Sináptica/fisiologia , Núcleos Vestibulares/fisiologia , Animais , Axônios/fisiologia , Axônios/ultraestrutura , Gatos/anatomia & histologia , Microscopia Eletrônica , Pescoço , Terminações Nervosas/ultraestrutura , Fito-Hemaglutininas , Medula Espinal/ultraestrutura , Coloração e Rotulagem
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