1.
Introducing a new class of N-phosphoryl ynamides via Cu(I)-catalyzed amidations of alkynyl bromides.
Org Lett
; 13(18): 4862-5, 2011 Sep 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21848304
RESUMO
We describe here the first synthesis of N-phosphoryl ynamides featuring C- and P-chirality via copper(I)-catalyzed amidative cross-couplings between phosphoramidates and phosphordiamidates with alkynyl bromides. Also featured is a tandem aza-Claisen-hetero-[2+2] cycloaddition for the synthesis of N-phosphoryl azetidin-2-imines.
Assuntos
Amidas/síntese química , Cobre/química , Hidrocarbonetos Bromados/química , Amidas/química , Catálise , Cristalografia por Raios X , Modelos Moleculares , Estrutura Molecular , Estereoisomerismo
2.
Synlett
; 2010(16): 2397-2402, 2010 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21278848
RESUMO
A novel thermal 3-aza-Claisen rearrangement of N-allyl ynamides for the synthesis of α-allyl imidates is described. Also, a sequential aza-Claisen, Pd-catalyzed Overman rearrangement is described for the synthesis of azapine-2-ones.