[THERAPEUTIC POTENTIAL OF ALPHA-INTERFERON PREPARATIONS DUR- ING SOCIALLY-SIGNIFICANT HUMAN DISEASES OF VIRAL ETIOLOGY].

Interferons (IFN) belong to key cytokines of innate and adaptive immune response and play an important role in anti-viral and anti-tumor protection. At the same time, they possess a pro- nounced immune-modulating, anti-proliferative and anti-fibrotic effect. A general comparative characteristic of human IFN type I (α/ß), IFN type II (γ) and IFN type III (λ) and nosological directionality of contemporary drugs created on their base is examined in the review. Epidemiologic parameters for main socially-significant human diseases of viral etiology are presented: influenza and other ARVIs, herpes infection, chronic viral hepatitis B, C and D. Main attention is given to analysis of effectiveness of therapeutic application of preparations based on IFNα during the in- dicated infections, a specter of main IFNα induced side effects is listed. Recent achievements on the path of creation of principally new drugs based on IFN, that have lower toxicity and higher clinical effectiveness, as well as perspectives of application of preparations based on recombinant IFN for therapy of potentially, dangerous diseases are examined.

[The effect of a potential drug ingamine on a model of noninfectious pneumonia]. / Issledivanie éffektivnosti potentsial'nogo lekarstvennogo sredstva - ingamina TM na modeli neinfektsionnogo vospaleniia legkikh.

The potential drug ingamine (glutarylhistamine) showed pronounced anti-inflammatory activity on a model of acute noninfectious pneumonia and in the stage of chronic inflammation induced by singe instillation of Sephadex (5 mg/kg) in Wistar rats. A 6-day treatment with ingamine (50-500 microg/kg) by inhalation, intragastric, and intraperitoneal administration produced an anti-inflammatory effect (expressed to various degrees), which was manifested by a decrease in alveolitis, bronchitis, obstructive emphysema, lymphocyte-neutrophile infiltration of interalveolar septa, cytosis, and neutrophile component of bronchoalveolar lavage and by normalization of the cytogram. The most pronounced effect was observed upon inhalation in a dose of 500 microg/kg. In the stage of chronic inflammation, the inhalation of ingamine in a dose of 500 microg/kg produced a significant antiinflammatory action for both 10- and 20-day treatment. The effect was comparable with that of the inhaled glucocorticoid budesonide.