Overexploitation hazards and salinization risks in crucial declining aquifers, chemo-isotopic approaches.

Bastam region is overusing its groundwater resources stocks. The groundwater levels, and hydrogeochemical data during a 14-year period (2002-2016) and isotopic composition (2016) of the 22 groundwater samples were investigated to determine the hydrogeological regime of Bastam Plain and identify the geochemical processes that control the groundwater quality. This plain is situated in a semi-arid region of northern Iran, mainly recharging from the carbonate Mountains in the north and southwest. In general, overexploitation of the groundwater due to low precipitation and changing precipitation regime has destructive effects on the hydrogeological setting and flow regime of Bastam crucial aquifer, including the decline of the groundwater level with rate of 0.9 m/year, water storage deficit of 17.32 Mm3/year and consequently, the intrusion of saline water towards the aquifer from the western and eastern salty plains. Based on the EC values, the groundwater samples divided into three groups of fresh waters with EC < 1000 µS/cm and Ca-Mg-HCO3 water type which are located in the recharge zones, semi-saline waters (1000 < EC < 2500 µS/cm) with Na-Mg-Cl-SO4 type at the center and saline waters with EC values more than 2500 µS/cm and Na-Cl type in the eastern and western parts of the plain. A few groundwater samples (group 2) fall on the mixing line between fresh and saline water in Piper diagram during the saline water intrusion, but most of the samples depart from this mixing line, indicating water-rock interactions in this area, resulting in deficit of Na+ and surplus of Ca2+ concentration. The fresh water samples cluster along the local meteoric water line in δ18O and δ2H relationships, suggesting an integrative and rapid recharge with meteoric water. Hydrochemical and isotopic characteristics indicate that invasion of the saline water resulted from halite dissolution with minor evaporation in the surrounding salty playas is the main origin for the increasing salinity in the Bastam aquifer. The salinization risks limit the groundwater withdrawals from Bastam aquifer in some areas, threatening the future sustainable development of the region.

Unhealthy lifestyles and ischaemic electrocardiographic abnormalities: the Persian Gulf Healthy Heart Study.

We assessed prevalence of cardiovascular risk factors, ischaemic heart disease (IHD) and unhealthy lifestyles in 3723 participants aged > or = 25 years in the northern Persian Gulf region; 96.0% had > or = 1 cardiovascular risk factor. Over 60% had unhealthy body weight, only 8.3% ate the recommended amount of fruits and vegetables, 70.6% were physically inactive and 19.0% were current smokers. Prevalence of electrocardiogram (ECG) with evidence of IHD was 12.7%. Present or past smoking and truncal obesity were independently associated with IHD ECGs in men, and past or present smoking and obesity in women. Hypertension and diabetes were independently associated with increased risk of IHD ECG.

Unhealthy lifestyles and ischaemic electrocardiographic abnormalities: the Persian Gulf Healthy Heart Study

We assessed prevalence of cardiovascular risk factors, ischaemic heart disease [IHD] and unhealthy lifestyles in 3723 participants aged >/= 25 years in the northern Persian Gulf region; 96.0% had >/= 1 cardiovascular risk factor. Over 60% had unhealthy body weight, only 8.3% ate the recommended amount of fruits and vegetables, 70.6% were physically inactive and 19.0% were current smokers. Prevalence of electrocardiogram [ECG] with evidence of IHD was 12.7%. Present or past smoking and truncal obesity were independently associated with IHD ECGs in men, and past or present smoking and obesity in women. Hypertension and diabetes were independently associated with increased risk of IHD ECG

Mycobacterial lipoarabinomannan induces nitric oxide and tumor necrosis factor alpha production in a macrophage cell line: down regulation by taurine chloramine.

Avirulent mycobacterium H37Ra lipoarabinomannan (LAM) elicited nitric oxide (NO) and tumor necrosis factor alpha in a dose-dependent manner in a murine macrophage cell line, RAW 264.7 cells. H37Ra LAM and recombinant gamma interferon were highly synergistic for NO production. The production of NO and the release of tumor necrosis factor alpha stimulated by H37Ra LAM plus recombinant gamma interferon in RAW 264.7 cells are inhibited by taurine chloramine.