Diagnosis and classification of Parkinson's disease using ensemble learning and 1D-PDCovNN.

In this paper, we proposed a novel approach to diagnose and classify Parkinson's Disease (PD) using ensemble learning and 1D-PDCovNN, a novel deep learning technique. PD is a neurodegenerative disorder; early detection and correct classification are essential for better disease management. The primary aim of this study is to develop a robust approach to diagnosing and classifying PD using EEG signals. As the dataset, we have used the San Diego Resting State EEG dataset to evaluate our proposed method. The proposed method mainly consists of three stages. In the first stage, the Independent Component Analysis (ICA) method has been used as the pre-processing method to filter out the blink noises from the EEG signals. Also, the effect of the band showing motor cortex activity in the 7-30 Hz frequency band of EEG signals in diagnosing and classifying Parkinson's disease from EEG signals has been investigated. In the second stage, the Common Spatial Pattern (CSP) method has been used as the feature extraction to extract useful information from EEG signals. Finally, an ensemble learning approach, Dynamic Classifier Selection (DCS) in Modified Local Accuracy (MLA), has been employed in the third stage, consisting of seven different classifiers. As the classifier method, DCS in MLA, XGBoost, and 1D-PDCovNN classifier has been used to classify the EEG signals as the PD and healthy control (HC). We first used dynamic classifier selection to diagnose and classify Parkinson's disease (PD) from EEG signals, and promising results have been obtained. The performance of the proposed approach has been evaluated using the classification accuracy, F-1 score, kappa score, Jaccard score, ROC curve, recall, and precision values in the classification of PD with the proposed models. In the classification of PD, the combination of DCS in MLA achieved an accuracy of 99,31%. The results of this study demonstrate that the proposed approach can be used as a reliable tool for early diagnosis and classification of PD.

A Novel Cuffless Blood Pressure Prediction: Uncovering New Features and New Hybrid ML Models.

This paper investigates new feature extraction and regression methods for predicting cuffless blood pressure from PPG signals. Cuffless blood pressure is a technology that measures blood pressure without needing a cuff. This technology can be used in various medical applications, including home health monitoring, clinical uses, and portable devices. The new feature extraction method involves extracting meaningful features (time and chaotic features) from the PPG signals in the prediction of systolic blood pressure (SBP) and diastolic blood pressure (DBP) values. These extracted features are then used as inputs to regression models, which are used to predict cuffless blood pressure. The regression model performances were evaluated using root mean squared error (RMSE), R2, mean square error (MSE), and the mean absolute error (MAE). The obtained RMSE was 4.277 for systolic blood pressure (SBP) values using the Matérn 5/2 Gaussian process regression model. The obtained RMSE was 2.303 for diastolic blood pressure (DBP) values using the rational quadratic Gaussian process regression model. The results of this study have shown that the proposed feature extraction and regression models can predict cuffless blood pressure with reasonable accuracy. This study provides a novel approach for predicting cuffless blood pressure and can be used to develop more accurate models in the future.

A Novel Approach to Skin Lesion Segmentation: Multipath Fusion Model with Fusion Loss.

Segmentation of skin lesions plays a very important role in the early detection of skin cancer. However, indistinguishability due to various artifacts such as hair and contrast between normal skin and lesioned skin is an important challenge for specialist dermatologists. Computer-aided diagnostic systems using deep convolutional neural networks are gaining importance in order to cope with difficulties. This study focuses on deep learning-based fusion networks and fusion loss functions. For the automatic segmentation of skin lesions, U-Net (U-Net + ResNet 2D) with 2D residual blocks and 2D volumetric convolutional neural networks were fused for the first time in this study. Also, a new fusion loss function is proposed by combining Dice Loss (DL) and Focal Tversky Loss (FTL) to make the proposed fused model more robust. Of the 2594 image dataset, 20% is reserved for test data and 80% for training data. In test data training, a Jaccard score of 0.837 and a dice score of 0.918 were obtained. The proposed model was also scored on the ISIC 2018 Task 1 test images, whose ground truths were not shared. The proposed model performed well and achieved a Jaccard index of 0.800 and a dice score of 0.880 in the ISIC 2018 Task 1 test set. In addition, it has been observed that the new fused loss function obtained by fusing Focal Tversky Loss and Dice Loss functions in the proposed model increases the robustness of the model in the tests. The proposed new loss function fusion model has outstripped the cutting-edge approaches in the literature.

Machine Learning and Electrocardiography Signal-Based Minimum Calculation Time Detection for Blood Pressure Detection.

Objective: Measurement and monitoring of blood pressure are of great importance for preventing diseases such as cardiovascular and stroke caused by hypertension. Therefore, there is a need for advanced artificial intelligence-based systolic and diastolic blood pressure systems with a new technological infrastructure with a noninvasive process. The study is aimed at determining the minimum ECG time required for calculating systolic and diastolic blood pressure based on the Electrocardiography (ECG) signal. Methodology. The study includes ECG recordings of five individuals taken from the IEEE database, measured during daily activity. For the study, each signal was divided into epochs of 2-4-6-8-10-12-14-16-18-20 seconds. Twenty-five features were extracted from each epoched signal. The dimension of the dataset was reduced by using Spearman's feature selection algorithm. Analysis based on metrics was carried out by applying machine learning algorithms to the obtained dataset. Gaussian process regression exponential (GPR) machine learning algorithm was preferred because it is easy to integrate into embedded systems. Results: The MAPE estimation performance values for diastolic and systolic blood pressure values for 16-second epochs were 2.44 mmHg and 1.92 mmHg, respectively. Conclusion: According to the study results, it is evaluated that systolic and diastolic blood pressure values can be calculated with a high-performance ratio with 16-second ECG signals.

A healthcare evaluation system based on automated weighted indicators with cross-indicators based learning approach in terms of energy management and cybersecurity.

OBJECTIVE: Hospital performance evaluation is vital in terms of managing hospitals and informing patients about hospital possibilities. Also, it plays a key role in planning essential issues such as electrical energy management and cybersecurity in hospitals. In addition to being able to make this measurement objectively with the help of various indicators, it can become very complicated with the participation of subjective expert thoughts in the process. METHOD: As a result of budget cuts in health expenditures worldwide, the necessity of using hospital resources most efficiently emerges. The most effective way to do this is to determine the evaluation criteria effectively. Machine learning (ML) is the current method to determine these criteria, determined by consulting with experts in the past. ML methods, which can remain utterly objective concerning all indicators, offer fair and reliable results quickly and automatically. Based on this idea, this study provides an automated healthcare system evaluation framework by automatically assigning weights to specific indicators. First, the ability of hands to be used as input and output is measured. RESULTS: As a result of this measurement, indicators are divided into only input group (group A) and both input and output group (group B). In the second step, the total effect of each input on the output is calculated by using the indicators in group B as output sequentially using the random forest of the regression tree model. CONCLUSION: Finally, the total effect of each indicator on the healthcare system is determined. Thus, the whole system is evaluated objectively instead of a subjective evaluation based on a single output.

A Novel Medical Diagnosis model for COVID-19 infection detection based on Deep Features and Bayesian Optimization.

A pneumonia of unknown causes, which was detected in Wuhan, China, and spread rapidly throughout the world, was declared as Coronavirus disease 2019 (COVID-19). Thousands of people have lost their lives to this disease. Its negative effects on public health are ongoing. In this study, an intelligence computer-aided model that can automatically detect positive COVID-19 cases is proposed to support daily clinical applications. The proposed model is based on the convolution neural network (CNN) architecture and can automatically reveal discriminative features on chest X-ray images through its convolution with rich filter families, abstraction, and weight-sharing characteristics. Contrary to the generally used transfer learning approach, the proposed deep CNN model was trained from scratch. Instead of the pre-trained CNNs, a novel serial network consisting of five convolution layers was designed. This CNN model was utilized as a deep feature extractor. The extracted deep discriminative features were used to feed the machine learning algorithms, which were k-nearest neighbor, support vector machine (SVM), and decision tree. The hyperparameters of the machine learning models were optimized using the Bayesian optimization algorithm. The experiments were conducted on a public COVID-19 radiology database. The database was divided into two parts as training and test sets with 70% and 30% rates, respectively. As a result, the most efficient results were ensured by the SVM classifier with an accuracy of 98.97%, a sensitivity of 89.39%, a specificity of 99.75%, and an F-score of 96.72%. Consequently, a cheap, fast, and reliable intelligence tool has been provided for COVID-19 infection detection. The developed model can be used to assist field specialists, physicians, and radiologists in the decision-making process. Thanks to the proposed tool, the misdiagnosis rates can be reduced, and the proposed model can be used as a retrospective evaluation tool to validate positive COVID-19 infection cases.

In vitro antioxidant activity of Ficus carica L. latex from 18 different cultivars.

As synthetic antioxidants that are widely used in foods are known to cause detrimental health effects, studies on natural additives as potential antioxidants are becoming increasingly important. In this work, the total phenolic content (TPC) and antioxidant activity of Ficus carica Linn latex from 18 cultivars were investigated. The TPC of latex was calculated using the Folin-Ciocalteu assay. 1,1-Diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and ferric ion reducing antioxidant power (FRAP) were used for antioxidant activity assessment. The bioactive compounds from F. carica latex were extracted via maceration and ultrasound-assisted extraction (UAE) with 75% ethanol as solvent. Under the same extraction conditions, the latex of cultivar 'White Genoa' showed the highest antioxidant activity of 65.91% ± 1.73% and 61.07% ± 1.65% in DPPH, 98.96% ± 1.06% and 83.04% ± 2.16% in ABTS, and 27.08 ± 0.34 and 24.94 ± 0.84 mg TE/g latex in FRAP assay via maceration and UAE, respectively. The TPC of 'White Genoa' was 315.26 ± 6.14 and 298.52 ± 9.20 µg GAE/mL via the two extraction methods, respectively. The overall results of this work showed that F. carica latex is a potential natural source of antioxidants. This finding is useful for further advancements in the fields of food supplements, food additives and drug synthesis in the future.

Parkinson disease classification using one against all based data sampling with the acoustic features from the speech signals.

Parkinson's disease (PD) is a long-term degenerative disease that primarily affects the motor system of the central nervous system. This disease is difficult to diagnose and is one of the common diseases in the public. In this paper, we have proposed a novel data sampling method for the classification of Parkinson disease based on the acoustic features from the speech signals. In the proposed data sampling method, the one against all (OGA) has been used to divide the dataset into five equal parts. With applying the OGA to the PD dataset having two classes (healthy and Parkinson disease), the minority and majority classes have been obtained. First of all, for healthy class in the dataset (first case), five equal partitions have been composed and then for PD class in the dataset (second case), five equal partitions have been composed. To classify the these all data partitions, we have used three different classifiers including the weighted k-NN (nearest neighbor), Logistic Regression (LR), and support vector machine with medium Gaussian kernel function. In order to evaluate the performance of the proposed hybrid models (the combination of classifiers and OGA based data sampling), the classification accuracy, the confusion matrix, and area under the Receiver Operating Characteristic (ROC) curve (AUC) have been used. While the LR, SVM with Gaussian, and weighted k-NN classifiers achieved the classification accuracies of 77.50%, 83.80%, and 82.10% in the classification of PD with the acoustic features, the combinations of classifiers and OGA based data sampling (first case) obtained the 79.04%, 87.36%, and 88.48% using the LR, SVM with Gaussian, and weighted k-NN classifiers, respectively. In the second case, the obtained classification accuracies are the 84.30%, 88.76%, and 89.46% using the LR, SVM with Gaussian, and weighted k-NN classifiers with the OGA based data sampling, respectively. The achieved results have shown that the proposed the one against all (OGA) based data sampling could be used in the combination of classifier algorithms as the data pre-processing method in the classification of Parkinson's disease with acoustic features.

Organosoluble Starch-Cellulose Binary Polymer Blend as a Quasi-Solid Electrolyte in a Dye-Sensitized Solar Cell.

This work is a pioneer attempt to fabricate quasi-solid dye-sensitized solar cell (QSDDSC) based on organosoluble starch derivative. Rheological characterizations of the PhSt-HEC blend based gels exhibited viscoelastic properties favorable for electrolyte fabrication. From amplitude sweep and tack test analyses, it was evident that the inclusion of LiI improved the rigidity and tack property of the gels. On the other hand, the opposite was true for TPAI based gels, which resulted in less rigid and tacky electrolytes. The crystallinity of the gels was found to decline with increasing amount of salt in both systems. The highest photoconversion efficiency of 3.94% was recorded upon addition of 12.5 wt % TPAI and this value is one of the highest DSSC performance recorded for starch based electrolytes. From electrochemical impedance spectroscopy (EIS), it is deduced that the steric hindrance imposed by bulky cations aids in hindering recombination between photoanode and electrolyte.

A unique in vivo approach for investigating antimicrobial materials utilizing fistulated animals.

Unique in vivo tests were conducted through the use of a fistulated ruminant, providing an ideal environment with a diverse and vibrant microbial community. Utilizing such a procedure can be especially invaluable for investigating the performance of antimicrobial materials related to human and animal related infections. In this pilot study, it is shown that the rumen of a fistulated animal provides an excellent live laboratory for assessing the properties of antimicrobial materials. We investigate microbial colonization onto model nanocomposites based on silver (Ag) nanoparticles at different concentrations into polydimethylsiloxane (PDMS). With implantable devices posing a major risk for hospital-acquired infections, the present study provides a viable solution to understand microbial colonization with the potential to reduce the incidence of infection through the introduction of Ag nanoparticles at the optimum concentrations. In vitro measurements were also conducted to show the validity of the approach. An optimal loading of 0.25 wt% Ag is found to show the greatest antimicrobial activity and observed through the in vivo tests to reduce the microbial diversity colonizing the surface.