RESUMO
Moexipril was given to 35 postmenopausal women with mild and moderate hypertension, menopausal syndrome and decreased bone mineral density. Blood pressure (BP) was measured before and in 1, 3, 6, and 12 months, while ultrasonic bone densitometry was carried out before and in 12 months of moexipril use. Significant lowering of systolic and diastolic BP, reduction of severity of climacteric syndrome occurred after 1, 3 and 6 months of moexipril use, respectively. After 12 months parameters of bone densitometry in moexipril treated women became better than in control group (p<0.01). Treatment was also associated with significant improvement of quality of life, diminished reactive anxiety and depression.
Assuntos
Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Densidade Óssea/efeitos dos fármacos , Climatério/efeitos dos fármacos , Hipertensão/tratamento farmacológico , Tetra-Hidroisoquinolinas/uso terapêutico , Inibidores da Enzima Conversora de Angiotensina/administração & dosagem , Inibidores da Enzima Conversora de Angiotensina/farmacologia , Pressão Sanguínea/efeitos dos fármacos , Interpretação Estatística de Dados , Feminino , Humanos , Hipertensão/fisiopatologia , Pessoa de Meia-Idade , Tetra-Hidroisoquinolinas/administração & dosagem , Tetra-Hidroisoquinolinas/farmacologia , Fatores de Tempo , Resultado do TratamentoRESUMO
AIM: To assess femoston effects on the cardiovascular system in postmenopause. MATERIAL AND METHODS: Cardiovascular effects of femoston were studied in 20 postmenopausal women with menopausal syndrome. 70% patients had arterial hypertension. Cardiovascular system was examined before the treatment and after three treatment months using 24-h monitoring of arterial pressure, echocardiography, photoplethysmography, conjunctival biomicroscopy, central hemodynamics tests. RESULTS: In the course of femoston treatment menopausal manifestations relieved, arterial pressure was lowering. 3-month treatment has improved parameters of central and peripheral hemodynamics: total peripheral vascular resistance significantly fell, stroke and minute blood volumes, cardiac indexrose, tissue blood flow and microcirculation improved. CONCLUSION: Femoston produces positive changes in cardiovascular system, vascular tone, microcirculation and arterial pressure.
Assuntos
20-alfa-Di-Hidroprogesterona/uso terapêutico , Sistema Cardiovascular/efeitos dos fármacos , Terapia de Reposição de Estrogênios , Estrogênios/uso terapêutico , Pós-Menopausa , Combinação de Medicamentos , Feminino , Hemodinâmica/efeitos dos fármacos , Humanos , Hipertensão/tratamento farmacológico , Pessoa de Meia-IdadeRESUMO
Serious affections of hemostasis were found in hemostatic examinations involving 67 intermittent claudication patients resistant to longterm vasodilative drugs. A 4-6-month course of tiklid (500 mg daily) induced a significant fall in platelet aggregation and an increase in the blood fibrinolytic activity, decreased foot chilliness, pain while walking. 73% of the patients could cover longer distances without pain complaints.
