RESUMO
The influence of myelopid (MP) on the protective activity of polycomponent vaccine VP-4 prepared from the antigens of opportunistic bacteria was studied on experimental infections of mice, caused by Klebsiella pneumoniae, Salmonella typhimurium and Staphylococcus aureus. In staphylococcal and Klebsiella infections the joint administration of vaccine VP-4 and MP produced more pronounced protective effect than each of these preparations, introduced alone. The protective action of vaccine VP-4 was specially enforced by MP in cases of local staphylococcal infection. Recommendations on the joint use of two or more immunomodulating agents are possible only on the basis of the experimental substantiation of their effect in definite infections.
Assuntos
Adjuvantes Imunológicos/administração & dosagem , Infecções Bacterianas/prevenção & controle , Vacinas Bacterianas/administração & dosagem , Oligopeptídeos/administração & dosagem , Animais , Masculino , Camundongos , Modelos Animais , Vacinas Combinadas/administração & dosagemAssuntos
Doença Imunoproliferativa do Intestino Delgado/patologia , Adulto , Endoscopia , Feminino , Humanos , Imunoquímica , Doença Imunoproliferativa do Intestino Delgado/diagnóstico por imagem , Linfonodos/diagnóstico por imagem , Linfonodos/patologia , Microscopia Eletrônica , Cavidade Peritoneal/diagnóstico por imagem , Cavidade Peritoneal/patologia , Tomografia Computadorizada por Raios XRESUMO
The authors review their 5-year experience with the work of the women's diagnostic department for recognition of cancer and precancer of the mammary gland. The efficacy of the activities of this diagnostic department is believed to be determined by two main factors: 1) proper organization of its activity and 2) its close contacts with an oncologist of the polyclinic.