Enfermidade de Charcot-Marie-Tooth - Transmissao dominante ligada ao X. / Charcot-Marie-Tooth disease - Dominant transmission X linked

Os AA. estudam uma familia com a doenca de Charcot-Marie-Tooth, na qual se verifica forma rara de transmissao genetica: dominante ligada ao cromossoma X. A concomitancia com a anemia falciforme e comentada. O aconselhamento genetico, motivo que levou o proposito a consulta, e analisado em seus diferentes aspectos

[Vincamine in patients with cerebral vascular insufficiency]. / Vincamina em pacientes com insuficiencia vascular cerebral

The effects of the treatment with vincamine in 20 patients with cerebral vascular insufficiency are reported. The patients were previously submitted to the following tests: neurologic examination, electroencephalography, laboratory tests, psychometry (memory, intellective capability, concentrated attention, abstract reasoning and personality tests). Patients were medicated with vincamin in a 40 mg dose within 24 hours during approximately a 150 days period, after which were again submitted to an identical analysis. The results obtained revealed that in a reasonable percentage of the cases vincamin is an useful medication in controlling the clinical manifestations of the cerebral vascular insufficiency, an improvement being demonstrated in the retrograde and anterograde deficit rate observed in objective tests. An improvement was also noticed in the electroencephalograpric pattern of a few patients.