[Immune response and the dynamics of the cytolysis syndrome in viral hepatitis A and B]. / Immunnyi otvet i dinamika sindroma tsitoliza pri virusnom gepatitie A i B.

Forty-nine patients with acute viral hepatitis A and B were examined for the relationship of the blood content of individual lymphocyte subpopulations at the height of the disease to subsequent duration of the cytolytic syndrome (high activity of ALT). The duration of the cytolytic syndrome associated with viral hepatitis A was reversely related to the content of B lymphocytes and when associated with viral hepatitis B to the content of T cells--immunoregulator precursors (autorosette-forming cells). In both patterns of viral hepatitis, the duration of the cytolytic syndrome did not depend on the rate of lymphocyte sensitization to the inducer antigens (HAVAg, kHBsAg). Unlike viral hepatitis A, the duration of the cytolytic syndrome in viral hepatitis B was directly related to the rate of lymphocyte sensitization to hepatic lipoprotein.

[Characteristics of immune response regulation in viral hepatitis A and B]. / Osobennosti reguliatsii immunnogo otveta pri virusnykh gepatitakh A i B.

In 272 patients with virus hepatitis A and B the content of theophylline-sensitive lymphocytes (T-suppressors) and theophylline-resistant lymphocytes (T-helpers) in the peripheral blood was determined. Differences in the content of T-suppressors in cases of acute virus hepatitis A and B with an equal degree of severity were revealed: at the peak of hepatitis A infection in the mild form of the disease the number of the cells was decreased, while at the peak of hepatitis B infection an increase in their number was observed in the mild and moderate forms of the disease and a decrease, in the severe form of the disease. In chronic persistent hepatitis a decrease in the content of T-suppressors and an increase in the content of T-helpers were observed, and in chronic active hepatitis (at the period of remission) and increase in the T-helpers occurred. Changes in the content of the cells of both types are not characteristic of HBsAg carriership.

[Changes in the count of highly avid, thermostable blood T-cells in viral hepatitis and its outcome]. / Izmenenie soderzhaniia vysokoavidnykh, termostabil'nykh T-kletok krovi pri virusnykh gepatitakh i ikh iskhodakh.

The determination of the content of thermostable T-lymphocytes in the peripheral blood in 184 patients with acute virus hepatitis, as well as at the stage of the termination of the disease, has revealed the increased number of cells belonging to this subpopulation in all the groups under study. At the acute stage of the disease a rise in the number of thermostable T-cells is directly related to the severity of the process. Of different variants of the termination of hepatitis B, the highest content of thermostable T-cells is observed in chronic active hepatitis and chronic HBsAg carriership, while in chronic persistent hepatitis the content of thermostable T-cells is considerably lower.

[Characteristics of the ultrastructural changes of the large intestine mucosa after acute dysentery]. / Osobennosti ul'trastrukturnykh izmenenii slizistoi obolochki tolstoi kishki u lits, perenesshikh ostruiu dizenteriiu.

Electron microscopic examinations of biopsy specimens of the large intestine from 8 patients one month after termination of the acute phase of dysentery revealed dystrophic and destructive changes in surface epithelium cells consisting in the lack of glycocalyx, fragmentation of microvilli, vacuolation and subsequent homogenization of the cytoplasm. Swelling and destruction of mitochondria, pyknosis and rhexisof the nucleus, exposure and loss of the intactness of the apical membrane of the cells were observed. The altered colonocytes frequently became detached off the basal membrane, exposing the stroma. The results of the study attest to long-term persistence of both the pathological and infectious processes in protracted forms of Shigella infection in man.