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1.
Food Res Int ; 170: 113013, 2023 08.
Artigo em Inglês | MEDLINE | ID: mdl-37316080

RESUMO

Fruits have relevant usefulness in the elaboration of nutraceutical compositions and, as it is considered a "natural medicine", its market has been growing exponentially each year. Fruits, in general, contain a large source of phytochemicals, carbohydrates, vitamins, amino acids, peptides and antioxidants that are of interest to be prepared as nutraceuticals. The biological properties of its nutraceuticals can range from antioxidant, antidiabetic, antihypertensive, anti-Alzheimer, antiproliferative, antimicrobial, antibacterial, anti-inflammatory, among others. Furthermore, the need for innovative extraction methods and products reveals the importance of developing new nutraceutical compositions. This review was developed by searching patents of nutraceuticals from January 2015 until January 2022 in Espacenet, the search database of the European Patent Office (EPO). Of 215 patents related to nutraceuticals, 43% (92 patents) were including fruits, mainly berries. A great number of patents were focused on the treatment of metabolic diseases, representing 45% of the total patents. The principal patent applicant was the United States of America (US), with 52%. The patents were applied by researchers, industries, research centers and institutes. It is important to highlight that from 92 fruit nutraceutical patent applications reviewed, 13 already have their products available on the market.


Assuntos
Suplementos Nutricionais , Frutas , Antioxidantes , Vitaminas , Aminoácidos
2.
Artigo em Inglês | MEDLINE | ID: mdl-35378013

RESUMO

Self-emulsifying drug delivery systems (SEDDS) are lipid-based isotropic mixtures that enhance the bioavailability of poorly water-soluble drugs and reduce the possible side effects, offering a wide variety of treatments for several pathologies. The aim of this review is to discuss the state of the art of patents for this drug delivery system by studying recent patent applications (2011 to 2020). We performed a thorough screening using the European Patent Office's Espacenet database, from which 37 inventions were selected and fully studied. China had more patent applications, and the articles published about SEDDS exceeds both in number and technological advance the submitted inventions. Nevertheless, the patents presented herein are innovative to address known issues to traditional SEDDS, including storage and formulation stability, solid formulations, acute gastrointestinal toxicity from surfactants, and drug delivery through alternative routes of administration. This study also revealed that release behavior for SEDDS and associated pharmacokinetics were not completely disclosed by the inventors of the patents and that further studies are required.


Assuntos
Sistemas de Liberação de Medicamentos , Tensoativos , Disponibilidade Biológica , China , Emulsões , Humanos
3.
Arch Biochem Biophys ; 648: 20-26, 2018 06 15.
Artigo em Inglês | MEDLINE | ID: mdl-29704483

RESUMO

Betulinic acid (BA) has been described as an insulin secretagogue which may explain its potent antihyperglycemic effect; however, the exact role of BA as an insulinogenic agent is not clear. The aim of this study was to investigate the mechanism of BA on calcium influx and static insulin secretion in pancreatic islets isolated from euglycemic rats. We found that BA triggers calcium influx by a mechanism dependent on ATP-dependent potassium channels and L-type voltage-dependent calcium channels. Additionally, the voltage-dependent and calcium-dependent chloride channels are also involved in the mechanism of BA, probably due to an indirect stimulation of calcium entry and increased intracellular calcium. Additionally, the downstream activation of PKC, which is necessary for the effect of BA on calcium influx, is involved in the full stimulatory response of the triterpene. BA stimulated the static secretion of insulin in pancreatic islets, indicating that the abrupt calcium influx may be a key step in its secretagogue effect. As such, BA stimulates insulin secretion through the activation of electrophysiological mechanisms, such as the closure of potassium channels and opening of calcium and chloride channels, inducing cellular depolarization associated with metabolic-biochemical effects, in turn activating PKC and ensuring the secretion of insulin.


Assuntos
Canais de Cloreto/metabolismo , Insulina/metabolismo , Canais de Potássio/metabolismo , Secretagogos/farmacologia , Triterpenos/farmacologia , Animais , Transporte Biológico/efeitos dos fármacos , Cálcio/metabolismo , Desoxiglucose/metabolismo , Ilhotas Pancreáticas/efeitos dos fármacos , Ilhotas Pancreáticas/metabolismo , Masculino , Triterpenos Pentacíclicos , Ratos , Ratos Wistar , Ácido Betulínico
4.
Repert. med. cir ; 16(1): 33-36, 2007. tab
Artigo em Espanhol | LILACS, COLNAL | ID: lil-523233

RESUMO

Se presentan 16 mujeres con cáncer de cérvix (CCU) estadio IB1, a quienes se les practicó histerectomía radical modificadatipo Wertein más linfadenectomía pélvica bilateral como tratamiento de primera línea, evaluadas en el servicio deoncología ginecológica del Hospital San José de Bogotá (HSJ) entre los años 2000 y 2005. Se determinó la morbilidad delprocedimiento, definida como las complicaciones médicas o quirúrgicas derivadas del mismo, y se correlacionó con lasvariables edad, antecedentes médicos, tipo histológico, sangrado transoperatorio, duración del procedimiento, estanciahospitalaria, necesidad de tratamiento complementario, seguimiento y recaída.


Assuntos
Humanos , Neoplasias do Colo do Útero , Procedimentos Cirúrgicos em Ginecologia , Doenças Urogenitais Femininas , Histerectomia Vaginal
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