[Status of the blood and lung antioxidant system of the rat in toxic pulmonary edema]. / Sostoianie antioksidantnoi krovi i legkikh krys pri toksicheskom oteke legkikh.

The state of enzymatic and non-enzymatic components of antioxidant system and also lipid peroxidation processes in blood and lungs of rats with toxic pulmonary edema induced by inhalation of nitric oxides were investigated. The changes in the state of blood and lung antioxidant system components accompany the development of toxic pulmonary edema and coincide in time-course of edema manifestation. The determined changes were more pronounced in blood than in lungs.

[A change in the composition of cardiac membrane phospholipids in the process of nonspecific myocardial adaptation]. / Izmenenie sostava membrannykh fosfolipidov serdtsa v protsesse nespetsificheskoi adaptatsii miokarda.

The content and composition of cardiac phospholipids (PL) were investigated under the action of a new neuroactive inhibitory amino acid designed on the molecular basis. I.p. injection of the drug in rats was shown to cause no changes in PL levels and to alter the composition of metabolically important PL fractions (phosphatidylinositol, phosphatidylserine). These changes may be involved in the nonspecific adaptation of the heart to damaging exposures and in the cardioprotective action of substances, such as antihypoxants.

[Cardiac phospholipids in the dynamics of experimental myocardial infarct in rats]. / Fosfolipidy serdtsa v dinamike éksperimental'nogo infarkta miokarda u krys.

The study was undertaken to examine the cardiac levels and composition of phospholipids (PL) in the time course of rat experimental myocardial infarction (EMI) caused by the Selye procedure. The course of EMI was shown to be accompanied by a rise in the total levels of PH in the cardiomyocytic membranes, which was observed 1 hour and 14 days after the occurrence of EMI. Analyzing the composition of individual PL demonstrated higher concentrations of the minor PL phosphatidylserine and phosphatidylinositol, as well as differently directed changes in the content of massive PL: lower concentrations of phosphatidylethanolamine and higher levels of phosphatidylcholine. The pattern of the found changes altered in relation to the duration of EMI. By and large, the revealed changes reflect the processes of transbilayer redistribution of PL, alterations in their physicochemical properties and in the rate of lipid peroxidation occurring in the membranes.