[Long-term consequences of COVID-19 in patients with functional bowel disorders, rehabilitation prospective of microbiocenosis-oriented therapy].

AIM: To analyze long-term consequences of the new coronavirus infection and rehabilitation prospective of microbiocenosis-oriented therapy in patients with functional bowel disorders. MATERIALS AND METHODS: The study enrolled 100 consecutive patients with various types of functional bowel disorders with recurrence of symptoms after the new coronavirus infection. The severity of abdominal pain was evaluated in points, and bowel movement disorders were assessed using the Bristol stool scale. A questionnaire was used as part of an in-depth clinical examination for COVID-19 survivors to identify the clinical symptoms typical for the post-COVID syndrome. The Hospital Anxiety and Depression Scale was used to identify and assess the severity of depression and anxiety, and the Asthenic State Scale was used to diagnose the asthenia. RESULTS: All patients in the study subjectively linked the recurrence of bowel disorders with the new coronavirus infection. The most common bowel disorder was irritable bowel syndrome with diarrhea. A distinctive feature of exacerbations of intestinal symptoms in the post-COVID period is their association with depression/anxiety and asthenic states. The addition of Zakofalk® metaprebiotic to the treatment regimen was associated with significant regression of abdominal pain and normalization of bowel movement, an improvement of asthenia, anxiety, and depression. CONCLUSION: The addition of Zakofalk® to treatment regimens for exacerbations of functional bowel disorders after the new coronavirus infection significantly improves the effectiveness of therapy.

[Gastroenterological symptoms in COVID-19 patients with mild severity of the disease: opportunities to optimize antidiarrheal therapy].

BACKGROUND: The novel coronavirus infection COVID-19 can be manifested by damage to the organs of the gastrointestinal tract (GIT). Damage to the gastrointestinal tract by the SARS-CoV-2 virus leads to a violation of the microbial-tissue complex of the mucous membrane of the digestive tract. A common gastroenterological manifestation of COVID-19 is diarrhea. AIM: Study of the clinical features of gastroenterological disorders and the possibility of optimizing the treatment of diarrheal syndrome in patients with COVID-19 with a mild form of viral infection. MATERIALS AND METHODS: The observation group consisted of 230 patients with mild COVID-19: K-group (n=115) with respiratory symptoms, I group (n=115) with gastrointestinal manifestations in combination and without signs of respiratory damage. In order to compare the effectiveness of treatment of diarrheal syndrome, patients of group I are randomized into 2 subgroups: Ia (n=58) prebiotic treatment (Zacofalk) and Ib (n=57) enterosorbents. RESULTS: The development of gastrointestinal symptoms with SARS-CoV-2 infection is significantly more often noted in comorbid patients (67%). Gastrointestinal symptoms were dominated by diarrhea (93.9%) and flatulence (76.5%), in 1/3 of patients they were the first manifestos of infection. It was established that in 98.4% of patients of group I (against 42.6% of the K-group) signs of infectious intoxication were detected. In patients with gastrointestinal lesions, an elongation of the febrile period by 91.5 days was noted, a later (6 days) verification of the viral etiology of the disease. It was found that in patients of group I, the regression of clinical symptoms, the duration of viral disease, the dynamics of antibody formation, the prognosis for the development of IBS-like disorders in the post-infectious period depended on the treatment. In patients taking (Zacofalk), these indicators were significantly better. CONCLUSION: In mild cases, to reduce the severity of viral intestinal damage, for effective relief of intestinal symptoms, to reduce the risk of IBS-like symptoms, it is advisable to prescribe (Zacofalk) in an initial dose of 3 tablets per day.

[Electrogastrography in diagnosis of ulcerative pyloroduodenal stenosis]. / Elektrogastrografiia v diagnostike iazvennogo piloroduodenal'nogo stenoza.

Skin electrogastrogram was made in 40 healthy controls and 32 patients with ulcerative pyloroduodenal stenosis in fasting condition and after mixed meal. Fasting frequency of gastric bioelectric activity (BA) was similar in the patients and the controls (2.65 +/- 0.008; 2.65 +/- 0.008; p < 0.01). BA frequency unstability factor (FUF) was not so high in patients compared to controls (13.9 +/- 0.07; 15.3 +/- 0.11; p < 0.01). The meal produced a significant rise in the frequency, amplitude and a decrease in FUF of gastric BA in the patients and controls but in patients a fall in FUF was greater. A rise in the amplitude of gastric BA in patients was more pronounced than in controls (250.6 +/- 5.17%, 162.0 +/- 2.23%; p < 0.01). In patients the amplitude increased greater in compensated stenosis, weaker--in decompensated stenosis. The changes in gastric BA amplitude varied with severity of pyloroduodenal stenosis.

[The effect of hyperbaric oxygenation on the secretory, motor function and microcirculation of the stomach and duodenal walls in patients with duodenal ulcers]. / Vliianie giperbaricheskoi oksigenatsii na sekretornuiu, motornuiu funktsiiu i mikrotsirkuliatsiiu stenki zheludka i dvenadtsatiperstnoi kishki u bol'nykh s duodenal'nymi iazvami.

A total of 22 patients with duodenal ulcer were examined for secretory and motor functions, microcirculation of the gastroduodenal wall and changes in the stomach-duodenum interrelations under the influence of hyperbaric oxygenation. Of these, group I included 9 patients with active ulcer; group II 13 persons with a healing ulcer. To assess gastric and duodenal functions, use was made of pH-metry combined with the measurement of intraluminal pressure by "open catheters". Microcirculation of the gastroduodenal wall was estimated by the radiation method. The studies have shown that the patients with active ulcer treated by hyperbaric oxygenation manifested a decrease of motor activity of both stomach and duodenum, an improvement of acid-neutralizing function of the stomach, a reduction of the duration of duodenum acidification, a greater normalization of microcirculation in the duodenal wall than in the gastric wall. In the patients with healing ulcers, the duodenal motility returned to normal, the initially elevated gastric motility fell to normal, the acidification of the duodenal bulb declined, and the regional blood flow returned to normal. It may thus be concluded that the positive impact of hyperbaric oxygenation on gastroduodenal function was more pronounced in the patients with healing ulcers where a more considerable decrease of motor activity was not accompanied by duodenal motility suppression.