Heat Capacity and Thermodynamic Functions of Titanium-Manganites of Lanthanum, Lithium and Sodium of LaLi2TiMnO6 and LaNa2TiMnO6.

Titanium-manganites of LaLi2TiMnO6 and LaNa2TiMnO6 were synthesized by the methods of ceramic technology from the oxides of lanthanum, titanium (IV), manganese (III), and the carbonates of lithium and sodium. The types of their syngony and the parameters of their gratings were determined radiographically. The isobaric heat capacities of titanium-manganites were measured with experimental calorimetry in the range of 298.15-673 K. It was found that on the dependence curve of heat capacity versus temperature of C°p~f(T), for LaLi2TiMnO6 at 348 K and 598 K, and LaNa2TiMnO6 at 348 K, there are abnormal jumps in heat capacity, probably related to phase transitions of the second kind. Taking into account the temperatures of the phase transitions, the equations of the temperature dependence of the heat capacity of titanium-manganites were derived. Their standard entropies were calculated by the ion increments method. Temperature dependences of the thermodynamic functions of S°(T), H°(T)-H°(298.15), and Φxx(T) were calculated using the experimental data on heat capacities and the calculated values of the standard entropies. The standard heat capacities of the studied compounds were calculated by the independent methods of ion increments and Debye, the values of which were in satisfactory agreement with the experimental data. The standard enthalpy of the formation of LaLi2TiMnO6 and LaNa2TiMnO6 was calculated according to the methodology developed by the authors. The conducted electrophysical studies determined the nature of the second-order phase transition and the semiconductor features of their conductivity. Thus, all the above-mentioned data on the experimental and calculated studies of the temperature dependence of heat capacity, the thermodynamic functions to determine a standard enthalpy of formation of LaLi2TiMnO6 and LaNa2TiMnO6, and the investigation of their electrical properties are absolutely new, and they have no analogues.

Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia.

MATERIALS AND METHODS: 51 patients with CAP were divided into 2 groups depending on the severity of the pathological process. The first group (I) consisted of 32 patients with moderate severity of pneumonia. The second group (II) consisted of 19 patients with severe pneumonia. The third group (III), the comparison group, consisted of 14 CAP patients with chronic obstructive pulmonary disease (COPD). The control group consisted of 19 volunteers. RESULTS: Statistically significant increase in the level of carbonyl derivatives (CD) in patients of all study groups relative to the control group was revealed. In the group of patients with moderate severity and severe pneumonia, also in CAP patients with COPD, the level of CD exceeded the control group. There was no statistically significant difference in the level of advanced oxidation protein products (AOPP) and myeloperoxidase (MPO) in blood neutrophils between the studied groups. CONCLUSION: Results indicate an oxidative imbalance in neutrophils and contribute to the worsening of the course of the disease.

Obtaining and Investigation of the ß-Cyclodextrin Inclusion Complex with Vitamin D 3 Oil Solution.

Background. The research results of fat-soluble vitamin D 3 (cholecalciferol) encapsulation with ß-cyclodextrin have been presented in this work. The vitamin D 3 inclusion complex with ß-cyclodextrin was obtained under microwave radiation. The surface morphology of obtained clathrate inclusion complexes was described with the help of a scanning electron microscope. The thermographic measurement results on a differential scanning calorimeter have been presented. The activation energy of the ß-cyclodextrin : vitamin D 3 clathrate complex thermal oxidative destruction reaction was calculated. The clathrate thermal destruction kinetic parameters were determined. The inclusion complex spectral properties were characterized by IR-Fourier and 1H and 13C NMR spectroscopy. The existence of ß-cyclodextrin inclusion complex with vitamin D 3 in a 2 : 1 ratio was confirmed by the experimental results. The activation energy of thermal destruction of the inclusion complex of ß-cyclodextrin with vitamin D 3 was calculated using four different methods.

The Oxidized proteins and activity of the Cl-/HCО3- exchanger in erythrocytes of patients with acute alcohol intoxication.

BACKGROUND: The purpose of this research was to study the morphological properties and the products of oxidative protein modification in erythrocytes of patients with acute alcohol intoxication. Two groups of subjects were analyzed. The first one included 39 patients with acute alcohol intoxication. The second group consisted of 14 healthy subjects. METHODS: In erythrocytes the activity of Cl-/HCО3- exchanger, the reactive protein carbonyl derivatives and membrane-bound hemoglobin concentration were measured. RESULTS: Our results demonstrated strong alteration of the Cl-/HCО3- exchanger activity in erythrocytes of patients with acute alcohol intoxication. A delay in the beginning of hemolysis during incubation of erythrocytes in the ammonium medium was observed. The concentration of protein carbonyls in erythrocytes of patients significantly increased in comparison to the control ones. A decrease in the membrane-bounded hemoglobin was observed as well. CONCLUSIONS: These findings indicate that ethanol toxicity is manifested by alteration of oxidized protein concentration and Cl-/HCО3- exchanger activity in erythrocytes. It is hypothesized that oxidized proteins are implicated in modulation of the erythrocyte cell volume regulation.