RESUMO
The toxicity of Pluronic F-68, a non-ionic polyol, was studied in the rat when administered intravenously for one month in daily doses of 0, 10, 20, 50, 100, 200, 500 and 1000 mg/kg. Pluronic F-68 induced pulmonary foam cells at the dose levels of 500 and 1000 mg/kg and slight focal degenerative changes in the proximal tubules of the kidneys at the dose levels of 100, 200, 500 and 1000 mg/kg. The cytoplasm of the pulmonary foam cells contained lipid droplets, phospholipids being the most essential constituent. The results indicate that Pluronic F-68 is able to induce phospholipidosis in the rat. Only drugs have so far been reported to cause this condition in the rat.
Assuntos
Rim/efeitos dos fármacos , Pulmão/efeitos dos fármacos , Poloxaleno/toxicidade , Polietilenoglicóis/toxicidade , Animais , Feminino , Células Espumosas/efeitos dos fármacos , Rim/metabolismo , Rim/patologia , Lipidoses/induzido quimicamente , Lipidoses/patologia , Pulmão/metabolismo , Pulmão/patologia , Fosfolipídeos/metabolismo , RatosRESUMO
In institutes where sheep are used for laboratory purposes, the common use of commercial pellet food increases the risk of copper intoxication, as the mineral supplement in sheep pellets is equal to that used for cattle, and consequently too high. Therefore we strongly urge that this kind of food should be given in very restricted quantities to sheep, particularly those kept for laboratory purposes. It is also our opinion that sheep pellets with a much lower copper concentration should be commercially available.
