1.
Hum Pathol
; 28(11): 1302-6, 1997 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9385938
RESUMO
Immunohistochemical analysis of curettage material from a placental site trophoblastic tumor (PSTT) revealed a high expression of p53 gene products, of epidermal growth factor receptor (EGF-R) and of Ki-67 (MIB-1) proliferation associated antigen. bcl-2 was not expressed. These results show that in PSTT inactivation/dysregulation of p53 and upregulation of EGF-R and MiB-1 occurs, indicating that these factors are probably involved in tumor genesis and propagation of PSTT. The prognostic significance of the molecular genetic data, however, remains to be established.
Assuntos
Receptores ErbB/análise , Tumor Trofoblástico de Localização Placentária/química , Proteína Supressora de Tumor p53/análise , Neoplasias Uterinas/química , Adulto , Biomarcadores/análise , Gonadotropina Coriônica/análise , Feminino , Humanos , Imuno-Histoquímica , Antígeno Ki-67/análise , Lactogênio Placentário/análise , Gravidez
2.
Gynakol Rundsch
; 29 Suppl 2: 59-60, 1989.
Artigo
em Alemão
| MEDLINE
| ID: mdl-2613084
3.
Arch Gynecol Obstet
; 245(1-4): 746-8, 1989.
Artigo
em Alemão
| MEDLINE
| ID: mdl-2802760