RESUMO
The synthesis of a new family of antiviral compounds, 2-methoxy-, and 2-methylthio-6-[(2'-alkylamino)ethyl]-4(3H)-pyrimidinones, has been accomplished. The activity of these agents against positive strand (rubella virus and sindbis virus) and negative strand (vesicular stomatitis virus) RNA viruses is reported. Some of these compounds are efficient and selective inhibitors of rubella virus.
Assuntos
Antivirais/síntese química , Antivirais/farmacologia , Pirimidinonas/síntese química , Pirimidinonas/farmacologia , Vírus da Rubéola/efeitos dos fármacos , Animais , Antivirais/química , Sobrevivência Celular/efeitos dos fármacos , Chlorocebus aethiops , Testes de Sensibilidade Microbiana , Estrutura Molecular , Pirimidinonas/química , Vírus da Rubéola/crescimento & desenvolvimento , Análise Espectral , Células Vero , Ensaio de Placa ViralRESUMO
In 6000 cases of hysterectomy nine adenomatoid tumors of myometrium were observed. Macroscopically, the adenomatoid tumour appears as a round or ovoid mass of grey or whitegrey colour about the size of a hazel-nut. Microscopically, four types are distinguished: solid, angiomatoid, macrotubular and mixed types. The cytoplasma of the cells tends to be vacuolated, the glandlike spaces being probably derived by confluence of these vacuoles. The interstitial tissue contains cells of the same type and often lymphocytes. Several hypotheses concerning the histogenesis of adenomatoid tumors are reviewed. The adenomatoid tumor is more frequent in the myometrium than it has been hitherto known. Probably the tumor is often misinterpreted as leiomyoma of the uterus on the basis of macroscopical appearance only.
