Longitudinal association between oral function and underweight onset among community-dwelling older adults: Role of regular self-weighing.

AIMS: Regular self-weighing is effective in weight management and may help to mitigate the risk of underweight among older adults. We examined which factors of oral function are associated with a risk for underweight among community-dwelling older adults and whether regular self-weighing can mitigate that risk. METHODS: This was a cohort study. Self-administered questionnaires were mailed to 7665 older adults in March 2019 (response rate 74.3%) and 7591 in March 2020 (response rate 74.7%). Among those who responded to both surveys, 3594 older adults who were not underweight in March 2019 were included (follow-up rate: 59.2%). We examined the association between dysphagia, poor masticatory function, and dry mouth and the development of underweight, and whether regular self-weighing reduced the risk for underweight. RESULTS: The average age ± standard deviation of participants was 71.1 ± 3.4 years. There was a significant association between swallowing difficulty and the occurrence of underweight (odds ratio = 1.65, p = .012). However, this relationship did not differ significantly with regular self-weighing (p = .477). CONCLUSIONS: These study findings suggest that to prevent underweight among community-dwelling older adults, it is important to focus on those with poor swallowing function.

Effects of dance video game training on cognitive functions of community-dwelling older adults with mild cognitive impairment.

BACKGROUND: Some patients with minor cognitive impairment can revert to normal cognition if intervention is implemented early. Dance video games as multi-task training have shown beneficial effects on cognitive and physical functions in older adults. AIMS: This study aimed to elucidate the effects of dance video game training on cognitive functions and prefrontal cortex activity in older adults with and without mild cognitive impairment. METHODS: A single-arm trial was used for this study. The participants were divided based on the Japanese version of Montreal Cognitive Assessment scores into the mild cognitive impairment (n = 10) and normal cognitive function (n = 11) groups. Dance video game training was performed 60 min/day, 1 day/week, for a total of 12 weeks. Neuropsychological assessments, prefrontal cortex activity using functional near-infrared spectroscopy, and step performance of dance video game were recorded at pre- and post-intervention. RESULTS: Dance video game training significantly improved the Japanese version of Montreal Cognitive Assessment score (p < 0.05), and tendency toward improvement was observed in the trail making test in the mild cognitive impairment group. The dorsolateral prefrontal cortex activity in the Stroop color word test was significantly increased in the mild cognitive impairment group (p < 0.05) after dance video game training. CONCLUSIONS: Dance video game training improved cognitive function and increased prefrontal cortex activity in the mild cognitive impairment group.

Living Alone and Depressive Symptoms among Older Adults in the COVID-19 Pandemic: Role of Non-Face-to-Face Social Interactions.

OBJECTIVE: This study examined the association of living alone with changes in depressive symptom status and the moderating effect of non-face-to-face social interactions among older adults during the coronavirus disease (COVID-19) pandemic. DESIGN: A longitudinal study. SETTING AND PARTICIPANTS: This study recruited individuals aged ≥ 65 years without long-term care in one semi-urban city in Japan, who completed mailed questionnaires in March (baseline) and October 2020 (follow-up). METHODS: Based on depressive symptoms assessed by the Two-Question Screening at baseline and follow-up, participants were classified as: "non-case," "onset," "remission," and "persistence." Non-face-to-face social interactions during the pandemic, including phone calls or emails with separated families or friends, were dichotomized as "less than weekly interactions" and "weekly interactions." A multinomial logistic regression analysis was conducted to examine the association of living arrangement (living alone or together) with changes in depressive symptoms status. RESULTS: Data of 1001 participants were analyzed (mean age = 79.9 years). Of them, 13.8% lived alone. Overall, 40.6% participants were grouped as "non-case," 11.7% as "onset," 11.0% as "remission," and 27.1% as "persistence." Living alone was significantly associated with depressive symptom onset (odds ratio: 1.92; 95% CI: 1.03-3.56; P = .039), and a negative interaction (protective effect) was found between living alone and weekly non-face-to-face social interactions for depressive symptom onset. CONCLUSION AND IMPLICATIONS: During the pandemic, older adults living alone had a higher depressive symptom risk, but non-face-to-face social interactions may have buffered this risk. Our findings suggest the importance of supporting older adults living alone in times of social restrictions such as the pandemic, and furthermore, maintaining social connections, including non-face-to-face relationships, is necessary to protect their mental health.

Eating alone and weight change in community-dwelling older adults during the coronavirus pandemic: A longitudinal study.

OBJECTIVES: It is likely that the number of older adults who eat alone has increased during the COVID-19 pandemic. Older adults who eat alone tend to experience weight fluctuations. Weight loss and underweight in older adults cause health problems. The study objective was to longitudinally investigate the association between changes in eating alone or with others and body weight status in older adults. METHODS: This longitudinal cohort study was conducted in March and October 2020 in Minokamo City, Gifu Prefecture, Japan. Questionnaire data for 1071 community-dwelling older adults were analyzed. Multinomial logistic regression analysis was performed using changes in eating alone or with others as the independent variable and body weight status as the dependent variable. The analysis was adjusted for age, sex, living arrangements, educational level, diseases receiving medical treatment, cognitive status, depression, and instrumental activities of daily living. Missing data were imputed using multiple imputation. RESULTS: The average age of participants was 81.1 y (SD, 4.9 y). Individuals who reported eating alone in both surveys were more likely to report weight loss than those who reported eating with others in both surveys (adjusted model: odds ratio, 2.25; 95% confidence interval, 1.06-4.78; P = 0.04). CONCLUSIONS: These findings suggest that measures to prevent weight loss in older adults who eat alone are particularly important during the COVID-19 pandemic.

Social frailty and depressive symptoms during the COVID-19 pandemic among older adults in Japan: Role of home exercise habits.

OBJECTIVES: We examined the association between social frailty and depressive symptoms among community-dwelling older adults during the coronavirus disease 2019 pandemic. Additionally, we investigated whether home exercise habits moderated the impact of social frailty on depressive symptoms. METHODS: This cross-sectional study included 1,103 community-dwelling older adults (54.0% female, mean age [standard deviation] = 81.1 [5.0] years) from a semi-urban area of Japan who completed a mailed questionnaire survey in October 2020. Social frailty status was categorized as non-social frailty, pre-social frailty, and social frailty, which was assessed by financial difficulties, living alone, lack of social activity, and contact with neighbors. Depressive symptoms were defined as a Kessler 6 score ≥5. We performed a multivariable logistic regression analysis to examine the association between social frailty and depressive symptoms, and also conducted stratified analysis of home exercise habits during the pandemic. RESULTS: A total of 309 (28.0%) participants had depressive symptoms. Compared with non-social frailty, social frailty was associated with depressive symptoms (odds ratio [OR] = 1.80, 95% confidence interval [95%CI] = 1.16-2.79, p = 0.009). A similar relationship was observed in those who did not exercise at home (OR = 2.10, 95%CI = 1.14-3.84, p =0.017). However, no such relationship was observed in those who did exercise at home (OR = 1.50, 95%CI = 0.79-2.85, p =0.213). CONCLUSIONS: Social frailty was associated with a risk of depressive symptoms during the pandemic. In addition, our findings suggested that home exercise may buffer the association between social frailty and depressive symptoms.

Changes in psychosocial factors among community-dwelling older adults before and after Japan's declaration of a state of emergency over coronavirus disease 2019.

BACKGROUND: Social distancing measures to prevent the spread of coronavirus disease 2019 may cause changes in psychosocial factors. This study aimed to clarify changes in psychosocial factors among older adults before and after Japan's declaration of a state of emergency over coronavirus disease 2019. METHODS: This was a longitudinal cohort questionnaire study. A baseline survey was conducted in March 2020, and a follow-up survey was conducted in August 2020. The subjects were 1103 community-dwelling older adults not certified as having long-term care needs who responded to both the baseline and follow-up surveys. Changes in psychosocial factors before and after the state of emergency declaration were analysed by gender using the McNemar-Bowker test. RESULTS: Data for 397 men (mean age ± standard deviation: 80.6 ± 4.7 years) and 486 women (80.3 ± 4.3 years) were analysed in this study. The frequency of meeting friends increased over the study period for men (P = 0.04). An increasing number of women lived alone (P = 0.01). However, many people's financial status improved (P < 0.01), and the number of friends met in the previous month increased (P < 0.01). CONCLUSIONS: None of the examined psychosocial factors worsened, except for the increase in the number of women living alone. However, many of the study subjects refrained from engaging in certain activities. If the coronavirus disease 2019 pandemic persists, changes in psychosocial factors may occur. Therefore, a long-term investigation of the secondary psychosocial effects of coronavirus disease 2019 is necessary.

Association between family caregivers and depressive symptoms among community-dwelling older adults in Japan: A cross-sectional study during the COVID-19 pandemic.

OBJECTIVES: Novel coronavirus disease (COVID-19) pandemic could increase the mental health burden of family caregivers of older adults, but related reports are limited. We examined the association between family caregiving and changes in the depressive symptom status during the pandemic. METHODS: This cross-sectional study included 957 (mean age [standard deviation] = 80.8 [4.8] years; 53.5% females) community-dwelling older adults aged ≥ 65 years from a semi-urban area of Japan, who completed a mailed questionnaire. Based on the depressive symptom status assessed with the Two-Question Screen between March and October 2020, participants were classified into four groups: "non-depressive symptoms," "incidence of depressive symptoms," "remission from depressive symptoms," or "persistence of depressive symptoms." Participants were assessed in October 2020 for the family caregiving status, caregiving role, the severity of care recipients' needs, and increased caregiver burden during the pandemic, each with the simple question. Multinomial logistic regression analysis was applied to obtain the odds ratios (ORs) and 95% confidence intervals (CIs) for changes in depressive symptom status. RESULTS: Compared to non-caregivers, family caregivers were associated with the incidence (OR [95% CI] = 3.17 [1.55-6.51], p < 0.01) and persistence of depressive symptoms (OR [95% CI] = 2.39 [1.30-4.38], p < 0.01). Primary caregivers, caregivers for individuals with severe care needs, and caregivers with increased burden during the pandemic had a high risk of depressive symptoms. CONCLUSIONS: Family caregivers had a high risk of depressive symptoms during the pandemic. Our findings highlight the need for a support system for family caregivers.

Social Isolation and Self-Reported Cognitive Decline Among Older Adults in Japan: A Longitudinal Study in the COVID-19 Pandemic.

OBJECTIVES: We aimed to examine the association between the transition to social isolation and cognitive decline in older adults during the coronavirus disease 2019 (COVID-19) pandemic. DESIGN: Longitudinal study. SETTING AND PARTICIPANTS: The study included participants from a community in a semiurban area of Japan. We conducted a mailed questionnaire survey of 2000 noninstitutionalized older adults who were randomly sampled. Of those who completed both the baseline and follow-up surveys in March and October 2020, respectively, participants aged ≥70 years without cognitive impairment at baseline were included in the analysis. METHODS: Participants were classified into 4 groups based on their baseline and follow-up social isolation status, which were as follows: "remained nonisolated," "isolated from nonisolation," "nonisolated from isolation," and "consistent isolation." Self-reported cognitive function was assessed using the Cognitive Performance Scale, and level 2 (mild impairment) or higher (moderate to severe impairment) was defined as cognitive impairment. RESULTS: Ultimately, 955 older adults were analyzed. The mean age of the participants was 79.6 years (standard deviation = 4.7) and 54.7% were women. During the follow-up period, 54 (5.7%) participants developed cognitive impairment. Multivariable logistic regression analysis revealed that compared with the group that remained nonisolated, the isolated from nonisolation and consistent isolation groups were significantly associated with the onset of cognitive impairment [isolated from nonisolation: odds ratio (OR) = 2.74, 95% confidence interval (CI) = 1.13-6.61, P = .026; consistent isolation: OR = 2.33, 95% CI = 1.07-5.05, P = .033]. CONCLUSIONS AND IMPLICATIONS: Social isolation during the COVID-19 pandemic was associated with a decline in cognitive function among older adults. Attention to the social isolation process during the pandemic may be necessary to protect older adults' cognitive health.

Relationship Between Balance Recovery From a Forward Fall and Lower-Limb Rate of Torque Development.

The authors examined the relationship between the maximum recoverable lean angle via the tether-release method with early- or late-phase rate of torque development (RTD) and maximum torque of lower-limb muscle groups in 56 young healthy adults. Maximal isometric torque and RTD at the hip, knee, and ankle were recorded. The RTD at 50-ms intervals up to 250 ms from force onset was calculated. The results of a stepwise multiple regression analysis, early RTD for hip flexion, and knee flexion were chosen as predictive variables for the maximum recoverable lean angle. The present study suggests that some of the early RTD in the lower limb muscles, but not the maximum isometric torque, can predict the maximum recoverable lean angle.

Effect of ankle stretching combined with arm cycling on the improvement of calf muscle stiffness in patients with stroke: a pilot study.

[Purpose] This study aimed to ascertain whether ankle stretching combined with arm cycling compared with that without arm cycling results in greater improvement in maximum dorsiflexion range of motion (ROM), calf muscle stiffness, and gait velocity in the affected limb of patients with stroke. [Participants and Methods] Random ABAB reversal design was used in this study involving nine patients with stroke. Participants performed 10 min of ankle plantar flexor stretching through weight bearing using the tilt table under the following 2 conditions: with or without arm cycling at 60 revolutions per minute. Pre- and post-stretching maximum ROM and passive plantar flexion torque were measured using a custom-made passive torque indicator. Stiffness was calculated based on passive torque-angle relationships. [Results] Maximum ROM and stiffness significantly improved after stretching in both conditions, whereas no changes in gait velocity were found. The difference in pre- and post-stretching stiffness was significantly greater in the stretching with arm cycling group. Change in maximum ROM showed no difference between both stretching conditions. [Conclusion] This study indicates that ankle plantar flexor stretching combined with arm cycling was more effective than that without cycling in improving calf muscle stiffness in the affected limb of patients with stroke.

Differences in Falls between Older Adult Participants in Group Exercise and Those Who Exercise Alone: A Cross-Sectional Study Using Japan Gerontological Evaluation Study (JAGES) Data.

This study examined the difference in falls between older adults who participated in group exercise and those who exercised alone. We used cross-sectional data from the Japan Gerontological Evaluation Study. Data were obtained from functionally independent residents aged 65 years or older across 30 municipalities in Japan (n = 19,257). Logistic regression analysis was performed with experience of multiple falls over the past year as the dependent variable and type of exercise as the independent variable. Respondents were divided into three groups according to how they performed exercise: (1) non-exercisers (NE, no exercise), (2) those who only exercised alone (IE, individual exercise), and (3) those whose exercise included participation in group exercise (GE, group exercise). In total, 887 (4.6%) respondents reported multiple falls. After adjustment for 10 possible confounders, the GE group had an odds ratio (OR) for falls of 0.75 (95% confidence intervals 0.60⁻0.95) compared with the IE group. After adjustment for physiological factors and a psychological factor, the OR for the GE group increased slightly; however, an association between falls and exercise type was indicated. Older adults who participate in group exercise may receive additional benefits related to falls prevention compared with those who exercise alone.

Custom-made hinged knee braces with extension support can improve dynamic balance.

Background/Objective: We investigated whether custom-made hinged knee braces can facilitate knee extensor and flexor strength and influence functional performance as compared with other knee braces. METHODS: We enrolled 28 healthy young participants with no history of physical activity or brace use. The participants executed functional performance tests under the following 5 conditions: 1) without a knee brace, 2) wearing a knee sleeve, 3) wearing a hinged knee brace without assistance, 4) wearing a knee brace with extension support (KBE), and 5) wearing a knee brace with flexion support (KBF). The KBE and KBF were custom-made hinged knee braces equipped with rubber tubes. The functional performance tests performed assessed maximal isokinetic strength, single-leg jumping height/distance, anterior and posterior reach distance on a single leg, and dynamic balance ability. RESULTS: The benefit of the custom-made hinged knee brace was observed only during the anterior reach distance on a single leg. The KBE allowed a significantly greater single-leg anterior reach distance when compared to that in the no brace condition. There was a significant relationship between the improvement in the single leg anterior reach distance with KBE and the changes in isokinetic knee extension with KBE compared to the no brace condition. With regard to other parameters, there were no differences compared with the use of other knee braces and thus no apparent benefit. CONCLUSION: Our findings suggest that using a KBE enhances performance during dynamic balance activity in individuals who benefit from improved knee extension strength.

Beneficial effects of a gait used while wearing a kimono to decrease the knee adduction moment in healthy adults.

The knee adduction moment (KAM) relates to medial knee osteoarthritis (OA). Several gait modifications to reduce the KAM for the prevention of knee OA have been studied. Most of the modifications, however, involve voluntary changes in leg alignment. Here we investigated the biomechanical effects for reducing the KAM of a walking style with a small trunk rotation and arm swing gait, which is a natural walking style used while wearing a kimono (Nanba walk) that shifts the ground reaction force toward the stance leg (reduced lever arm). Twenty-nine healthy adults (21.5 ± 0.6 years) participated in the present study. A three-dimensional analysis system with 10 cameras and 1 force plate was used to obtain the KAM and other biomechanical data. Surface electromyography (EMG) of the hip and trunk muscles (internal obliquus abdominal muscle: IO, external obliquus abdominal muscle: EO, multifidus muscle: MF, and gluteus medius muscle: Gmed) was also assessed, and integrated EMG (iEMG) of the four muscles was assessed in the first and second halves of the stance phase. The 1st and 2nd peak KAMs were significantly decreased during Nanba walking (0.40±0.09 and 0.37±0.13 Nm/kg) compared with normal walking (0.45±0.09 and 0.45±0.13 Nm/kg; P = 0.002, P<0.001, respectively). The lever arm lengths at the 1st and 2nd peak KAMs were also significantly decreased during Nanba walking compared with normal walking (p = 0.023 and p<0.001, respectively). The iEMGs of IO, EO and Gmed muscles during the first half, and the iEMGs of EO and GM during the second half of the stance phase were significantly increased during Nanba walking compared with normal walking. The Nanba gait modification could be a useful strategy for reducing the KAM with high activation of the trunk and hip joint muscles for the prevention and/or treatment of medial knee OA.

Effect of balance exercise in combination with whole-body vibration on muscle activity of the stepping limb during a forward fall in older women: a randomized controlled pilot study.

This study investigated the effects of balance exercise combined with whole-body vibration (WBV) on step performance and lower limb muscle activity during simulated forward falls using the tether-release method in older women. Twenty older women were assigned to either a WBV plus balance exercise group (WBV, n=10) or a balance exercise without vibration group (standard balance exercise group [STE], n=10). WBV performed weight-bearing exercises on a WBV platform combined with other balance exercises as a home program, whereas STE performed the same exercises without WBV. The exercise volume was equal in both intervention groups (3×/week for 12 weeks×30 min/session). The EMG and kinematic data of the stepping leg from the balance recovery step were examined before and after the intervention. While both groups extended step length during forward falls after the intervention, only WBV increased step velocity. EMG analysis of the balance recovery step showed that both groups increased peak EMG of knee flexor and extensor muscles after intervention. After intervention, WBV increased peak EMG of the plantar flexors, which are used to exert the push-off forces just before the leg swing. Balance exercise in older women resulted in significant improvements in the balance recovery step after a simulated forward fall. WBV also had the additional benefit of improved step velocity, which was reflected in increased activity of the plantar flexors in the stepping leg.

Immediate effects of varying cadence in bicycle ergometry on characteristics of gait and lower extremity motor activity in frail older adults.

AIM: This study examined the immediate effects of a 5-min pedaling period with varying cadence (VC) on various dimensions of gait function in frail older adults. METHODS: Twenty frail older adults (mean age 77.2 years) were randomly assigned to one of two groups: the VC group or the constant cadence (CC) group. Each group performed bicycle ergometry for 5 min at 20 W. The CC group pedaled continuously at a CC of 50 rpm, while the VC group pedaled continuously at cadences of 45, 55, 65, 55, and 45 rpm, in this order, changing cadence every 60 s. Immediately before and after bicycle ergometry, the following measurements were carried out: gait performance, muscle activity (electromyographic analysis), and knee motion analysis. RESULTS: CC did not significantly affect any of the measured parameters. In contrast, the VC group showed improvement in all three parameters: an increase in normal gait speed and cadence (p < 0.01), a reduction in the activation period (p < 0.04) and CI-THIGH (antagonistic coactivation time between knee flexor and extensor muscles, p < 0.05), and an increase in maximum knee extension angular velocity (p < 0.01). CONCLUSION: A short period of VC bicycle ergometry with low work intensity was effective in immediately improving gait function in frail older adults.

Differences in muscle activation patterns during step recovery in elderly women with and without a history of falls.

BACKGROUND AND AIMS: This study aimed at comparing the patterns of muscle activation used in stepping to regain balance during a forward fall between subjects with and without a history of falling and at identifying the causes of functional deficits in recovery stepping. METHODS: Elderly women with and without a history of falling (fallers: n = 12, mean age ± SD = 82.8 ± 4.5 years; non-fallers: n = 17, age = 81.4 ± 3.4 years) participated in the study. The subjects were suspended in a forward-leaning position by a lean-control cable with a load of 15 % of body weight and instructed to regain standing balance upon release by taking a single step forward. Electromyography (EMG) data were obtained from five lower extremity muscles on the stepping side, and the muscle activation patterns were compared between fallers and non-fallers. RESULTS: Fallers had a shorter step length and slower step velocity than non-fallers. The EMG time-to-peak for the gastrocnemius muscle, which provides push-off prior to foot lift-off, was slower for fallers than for non-fallers, whereas the EMG onset times of the biceps femoris and gastrocnemius muscles were similar between the groups. The fallers exhibited significantly delayed muscle deactivation of the upper leg and increased co-contraction between the rectus femoris and biceps femoris during the stepping phase than did the non-fallers. CONCLUSIONS: These findings suggest that the muscle activation pattern during the regain balance may reflect an inability to step forward rapidly in elderly women with a history of falls.

[Three cases of internal carotid artery dissection due to trivial trauma].

Three cases of internal carotid artery (ICA) dissection due to trivial trauma were reported. A 14-year-old, previously healthy, girl developed left hemiparesis after jogging. MRI sh owed cerebral infarction in the right basal ganglia and the MR angiography (MRA) revealed luminal narrowing of the right ICA as well as pseudolumen at the origin of the right ICA. She was treated with antithrombotic therapy. Follow-up MRA demonstrated normal signal in the right ICA. A 23-year-old woman admitted to the hospital because of minor facial injury due to a traffic accident. Although she had no apparent symptom, follow-up CT, one day after presentation,. showed cerebral infarction in the right basal ganglia. Angiography showed diminished luminal diameter of the right ICA. She was treated with antithrombotic therapy and follow-up angiography showed reconstitution of normal lumina of the right ICA. A 34-year-old woman was referred to our hospital because of transient ischemic attack following swimming. Neurological examination was normal and MRI did not show any ischemic lesion. MRA revealed diminished signal in the left ICA as well as string and pearl sign at the origin of the left ICA. She was treated with antithrombotic therapy, and follow-up angiography showed normalization of the left ICA. Cervical ICA dissection due to trivial trauma usually appears as an eccentric tapered stenosis arising at the origin of the ICA and resolves with complete or excellent recovery in most cases. Surgical or endovascular treatment should be reserved for patients who have persistent symptoms of ischemia despite adequate antithrombotic treatment.