Assuntos
Biomarcadores Tumorais/análise , Medula Óssea/patologia , Neoplasias Ósseas/patologia , Rabdomiossarcoma Alveolar/patologia , Actinas/análise , Adulto , Desmina/análise , Diagnóstico Diferencial , Feminino , Humanos , Técnicas Imunoenzimáticas , Microscopia Eletrônica , Proteínas S100/análise , Vimentina/análiseRESUMO
Male and female Wistar rats were exposed to waste gas arising from a plasma etching process in the semiconductor industries for six hr per day, five days per week, for four weeks in order to characterize subacute organ toxicity and genotoxicity. The waste gas was a complex mixture of different chlorinated hydrocarbons, inorganic by-products, and unused process gases, diluted by room air. Neither death nor behavioral changes occurred after subacute exposure. No significant exposure-related effects on body weight gain, hematology, or cardiovascular parameters were observed. Only slight effects on organ weights and clinical chemistry were seen in the exposed animals. The exposed rats of both sexes showed statistically significant increases in chromosomal aberrations and sister chromatid exchanges in bone marrow cells.
Assuntos
Aberrações Cromossômicas/genética , Substâncias Perigosas/toxicidade , Hidrocarbonetos Clorados/toxicidade , Exposição Ocupacional , Troca de Cromátide Irmã/efeitos dos fármacos , Administração por Inalação , Alumínio , Animais , Análise Química do Sangue , Peso Corporal/efeitos dos fármacos , Medula Óssea/efeitos dos fármacos , Células da Medula Óssea , Sistema Cardiovascular/efeitos dos fármacos , Feminino , Masculino , Tamanho do Órgão/efeitos dos fármacos , Ratos , Ratos Wistar , Semicondutores/normas , Troca de Cromátide Irmã/genética , Volatilização , Gerenciamento de ResíduosRESUMO
In dry etching processes--one of the sources of potential exposure to toxic wastes in the semiconductor industry--complex mixtures of inorganic and organic compounds arise from reactions between feed stock gases (BCl3/Cl2), top layers (aluminium photoresist), and the carrier gas (N2). Two different fractions of the complex mixture--one an ethanolic solution (ES) and the other an insoluble liquid residue (LR)--were examined for acute oral toxicity in rats. Analytical data showed that the ethanol soluble fraction contained mainly inorganic compounds, whereas the residue contained various halogenated hydrocarbons. Neither death nor behavioral changes occurred after oral administration and observation up to 23 days. ES caused a lower mean arterial blood pressure in both sexes, increased P-R-intervals in male rats, and caused some mild biochemical and hematological alterations and changes in relative organ weights compared to the control groups. Exposure to LR influenced food and water intake, and caused a significant decrease in body weights, signs of polyurie, as well as changes in various relative organ weights and biochemical and hematological parameters. The blood pressure of the male animals fell and the heart rates of both sexes decreased.
Assuntos
Alumínio , Hidrocarbonetos Halogenados/toxicidade , Resíduos Industriais , Semicondutores , Animais , Pressão Sanguínea/efeitos dos fármacos , Comportamento Alimentar/efeitos dos fármacos , Feminino , Frequência Cardíaca/efeitos dos fármacos , Testes Hematológicos , Fígado/efeitos dos fármacos , Fígado/patologia , Masculino , Tamanho do Órgão/efeitos dos fármacos , Ratos , Ratos Endogâmicos , Organismos Livres de Patógenos EspecíficosRESUMO
Shunting of cerebrospinal fluid to extracranial spaces has been a common and effective procedure for symptomatic therapy of hydrocephalus since the fifties. In 1954 the first spreading of tumor cells via a ventriculo-pleural shunt was reported. We are presenting a case of a 10 month old girl with a medulloblastoma of the lower brain stem with spreading of the intracranial tumor through a ventriculoperitoneal shunt. Further 43 cases of the world literature with shunt-associated metastasizing of brain tumors are analysed. The extraneural spreading of tumor cells through shunt tubes must be considered as a possible complication of the shunting procedure.
Assuntos
Neoplasias Cerebelares/cirurgia , Derivações do Líquido Cefalorraquidiano , Meduloblastoma/secundário , Inoculação de Neoplasia , Neoplasias Peritoneais/secundário , Neoplasias Cerebelares/patologia , Feminino , Humanos , Lactente , Meduloblastoma/patologia , Meduloblastoma/cirurgia , Neoplasias Peritoneais/patologia , Peritônio/patologiaAssuntos
Resíduos Industriais/efeitos adversos , Semicondutores , Animais , Pressão Sanguínea/efeitos dos fármacos , Medula Óssea/efeitos dos fármacos , Medula Óssea/ultraestrutura , Aberrações Cromossômicas , Drosophila melanogaster , Feminino , Frequência Cardíaca/efeitos dos fármacos , Indústrias , Masculino , Mutagênicos/toxicidade , Ratos , Ratos Endogâmicos , Recombinação Genética/efeitos dos fármacos , RiscoAssuntos
Neoplasias da Mama/patologia , Núcleo Celular/ultraestrutura , Condroma/patologia , Tumores de Células Gigantes/patologia , Osteoma/patologia , Mama/patologia , Calcinose/patologia , Divisão Celular/fisiologia , Feminino , Células Gigantes/patologia , Humanos , Pessoa de Meia-Idade , Osteoclastos/patologiaRESUMO
A 25 year old woman developed 2 subcutaneous myxomas one month after removal of an atrial myxoma. The pathogenesis of this event is discussed. Special attention was given to distinction between true myxomas and myxoid sarcomas as well as to myxomatous diathesis, caused by a widespread, genetically determined specific abnormality of certain mesenchymal cells (Swiss-syndrome). With all aspects considered, this appears to be the best interpretation of the case under review.