[New cerebrally active basic dithienyl compounds (author's tranls)]. / Neue zerebral wirksame basische Dithienyl-Verbindungen.

A review on new cerebrally active basic dithienyl compounds related to (+)-(R)-alpha-((S)-1-[(3,3-di-3-thienylallyl)amino]-ethyl)-benzylalcohol (tinofedrine) is presented. Tinofedrine was selected out of a large number of related compounds on account of its high increase of cerebral blood flow, its improvement of heart performance, of the metabolism of the brain, and because it is well toleraded. Different routes of synthesis are discussed.

[On the synthesis of the cerebrally active compound tinofedrine (author's transl)]. / Zur Synthese der zerebroaktiven Substanz Tinofedrin.

The synthesis of tinofedrine (I), (+)-(R)-alpha-((S)-1-[3,3-di-3-thienylallyl)amino]benzylalcohol, a new cerebrally active drug, and the verification of its structure by spectrometric methods are reported.